Morshuis, M. et al. European experience of DuraHeart magnetically levitated centrifugal left ventricular assist system. Eur. J. Cardiothorac. Surg. 35, 1020-1027

Heart & Diabetes Center, North Rhine-Westphalia, Bad Oeynhausen, Germany.
European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery (Impact Factor: 3.3). 03/2009; 35(6):1020-7; discussion 1027-8. DOI: 10.1016/j.ejcts.2008.12.033
Source: PubMed


The DuraHeart (Terumo Heart, Inc., Ann Arbor, Michigan, USA) is the world's first approved magnetically levitated centrifugal left ventricular assist system designed for long-term circulatory support. We report the clinical outcomes of 68 patients implanted with the DuraHeart as a bridge to cardiac transplantation in Europe.
Sixty-eight patients with advanced heart failure (six females), who were eligible for cardiac transplantation were implanted with the DuraHeart between January 2004 and July 2008. Median age was 58 (range: 29-74) years with 31% over 65 years. Thirty-three of these patients received the device as a part of the European multi-center clinical trial. Survival analyses were conducted for 68 patients and other safety and performance data were analyzed based on 33 trial patients.
Mean support duration was 242+/-243 days (range: 19-1148, median: 161) with a cumulative duration of 45 years. Thirty-five patients (51%) remain ongoing, 18 transplanted, 1 explanted, and 14 died during support with a median time to death of 62 days. The Kaplan-Meier survival rate during support was 81% at 6 months and 77% at 1 year. Of the 13 patients (21%) supported for >1 year, 4 supported for >2 years, 1 supported >3 years, 2 transplanted, 2 died, and 9 ongoing with a mean duration of 744+/-216 days (range: 537-1148, median: 651). Major adverse events included driveline/pocket infection, stroke, bleeding, and right heart failure. There was no incidence of pump mechanical failure, pump thrombosis, or hemolysis.
The DuraHeart was able to provide safe and reliable long-term circulatory support with an improved survival and an acceptable adverse event rate in advanced heart failure patients who were eligible for transplantation.

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    • "Third generation devices utilizing magnetic and/or hydrodynamic levitation of the impeller without any contact bearings with the pump include the extra-corporeal systems such as Levitronix CentriMag maglev pump,[40] the magnetically suspended axial flow INCOR (Berlin Heart AG, Berlin, Germany) LVAD,[41] the HeartWare which uses hydrodynamic and magnetic levitation for suspension,[42] the HeartMate III which uses full magnetic suspension[43] and the DuraHeart (Terumo Somerset, USA).[44] "
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