Cognitive functioning in breast cancer survivors: A controlled comparison

Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
Cancer (Impact Factor: 4.89). 04/2009; 115(8):1776-83. DOI: 10.1002/cncr.24192
Source: PubMed


The current study was performed to determine whether neuropsychologic functioning differs in breast cancer survivors 6 months after the completion of adjuvant treatment compared with women without cancer.
Participants were 187 women who were diagnosed with ductal carcinoma in situ or stage I or stage II breast cancer and 187 age-matched and geographically matched women without cancer. Of the survivors, 97 had been treated after surgery with chemotherapy only or chemotherapy plus radiotherapy and 90 had been treated after surgery with radiotherapy only (grading determined according to the American Joint Committee on Cancer grading system).
Small but statistically significant differences in cognitive functioning and cognitive impairment were observed in those survivors who were treated with chemotherapy and their matched controls, as well as in survivors treated with radiotherapy only and their matched controls. No group differences were observed with regard to cognitive symptoms.
Data from the current study suggest that cognitive deficits are subtle and likely the result of the general effects of cancer diagnosis and treatment rather than systemic treatment.

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    • "Basic questions about association between " affective " and " cognitive " processing can also be examined in the context of cancer treatment and survivorship. Cancer-related cognitive impairment may be influenced or exacerbated by affective challenges associated with cancer diagnosis and survivorship (e.g., Ahles et al., 2002; Wefel et al., 2010), although evidence for these effects are mixed and the mechanisms underlying them are poorly understood (see Ahles & Saykin, 2007; Jim et al., 2009). Affective science is relevant for understanding these cognitive impairments , given theoretical frameworks suggesting that " affect " and " cognition " may share neural processes (Barrett & Satpute, 2013; Lindquist & Barrett, 2012). "
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    • "Let's stick to visual search Now reanalyze the data These are tests which have some attention component N = 4 N = 2 N = 11 N = 10 Effect −2.0 −1.5 −1.0 −0.5 0.0 0.5 1.0 Jim 2009,Ruff 2&7 speed Jim 2009,Ruff 2&7 accuracy Scherwath 2006,D2 van Dam 1998,D2 van Dam 1998,Fepsy Visual Search Schagen 1999,D2 Schagen 1999,Fepsy Visual Search Ahles 2002,Trails B Collins 2009,Trails B Donovan 2005,Trails B van Dam 1998,Trails B Yamada 2010,Trails B Collins 2009,Trails B Hurria 2006,Trails B Wefel 2004,Trails B Wefel 2010,Trails B Schagen 1999,Trails B Ahles 2002,Trails A Collins 2009,Trails A Donovan 2005,Trails A Jim 2009,Trails A van Dam 1998,Trails A Yamada 2010,Trails A Collins 2009,Trails A Hurria 2006,Trails A Wefel 2004,Trails A Wefel 2010,Trails A Schagen 1999,Trails A Summary Effect −2.0 −1.5 −1.0 −0.5 0.0 0.5 1.0 Ahles 2002 Collins 2009 Donovan 2005 Jim 2009 van Dam 1998 Yamada 2010 Collins 2009 Hurria 2006 Wefel 2004 Wefel 2010 Schagen 1999 Summary Effect −2.0 −1.5 −1.0 −0.5 0.0 0.5 1.0 Ahles 2002 Collins 2009 Donovan 2005 van Dam 1998 Yamada 2010 Collins 2009 Hurria 2006 Wefel 2004 Wefel 2010 Schagen 1999 "
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