Applying the Evidence Do Patients With Stroke, Coronary Artery Disease, or Both Achieve Similar Treatment Goals?

Division of Cardiology, Canadian Heart Research Centre and Terrence Donnelly Heart Centre, University of Toronto, Canada.
Stroke (Impact Factor: 5.72). 02/2009; 40(4):1417-24. DOI: 10.1161/STROKEAHA.108.533018
Source: PubMed


The importance of early and aggressive initiation of secondary prevention strategies for patients with both coronary artery disease (CAD) and cerebrovascular disease (CVD) is emphasized by multiple guidelines. However, limited information is available on cardiovascular protection and stroke prevention in an outpatient setting from community-based populations. We sought to evaluate and compare differences in treatment patterns and the attainment of current guideline-recommended targets in unselected high-risk ambulatory patients with CAD, CVD, or both.
This multicenter, prospective, cohort study was conducted from December 2001 to December 2004 among ambulatory patients in a primary care setting. The prospective Vascular Protection and Guidelines-Oriented Approach to Lipid-Lowering Registries recruited 4933 outpatients with established CAD, CVD, or both. All patients had a complete fasting lipid profile measured within 6 months before enrollment. The primary outcome measure was the achievement of blood pressure (BP) <140/90 mm Hg (or <130/80 mm Hg for patients with diabetes) and LDL cholesterol <2.5 mmol/L (<97 mg/dL) according to the Canadian guidelines in place at that time (similar to the National Cholesterol Education Program's value of 100 mg/dL). Secondary outcomes include use of antithrombotic, antihypertensive, and lipid-modifying therapies.
Of the 4933 patients, 3817 (77%) had CAD only; 647 (13%) had CVD only; and 469 (10%) had both CAD and CVD. Mean+/-SD age was 67+/-10 years, and 3466 (71%) were male. Mean systolic and diastolic BPs were 130+/-16 and 75+/-9 mm Hg, respectively. Minor but significant differences were observed on baseline BP, total cholesterol, and LDL cholesterol measurements among the 3 groups. Overall, 83% of patients were taking a statin and 93% were receiving antithrombotic therapy (antiplatelet and/or anticoagulant agents). Compared with patients with CAD, those with CVD only were less likely to achieve the recommended BP (45.3% vs 57.3%, respectively; P<0.001) and lipid (19.4% vs 30.5%, respectively; P<0.001) targets. Among patients with CVD only, women were less likely to achieve the recommended BP and lipid targets compared with their male counterparts (for LDL cholesterol <2.5 mmol/L, 18.7% vs 23.8%, respectively; P=0.048). In multivariable analysis, patients with CVD alone were less likely to achieve treatment success (BP or lipid targets) after adjusting for age, sex, diabetes, and use of pharmacologic therapy.
Despite the proven benefits of available antihypertensive and lipid-lowering therapies, current management of hypertension and dyslipidemia continues to be suboptimal. A considerable proportion of patients failed to achieve guideline-recommended targets, and this apparent treatment gap was more pronounced among patients with CVD and women. Quality improvement strategies should target these patient subgroups.

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Available from: Lawrence Leiter, Sep 04, 2014
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    • "Even for patients who did not achieve the aggressive LDL target of <2.0 mmol/L, their mean LDL was only slightly (mean of 0.43 mmol/L) above target. Similarly, the proportion of patients achieving the blood pressure goal (79%) is higher than that reported for the general population (57% -58%)[35][37]. For those who did not achieve the goal, their BP readings were only 1 -6 mmHg above their target. "

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    • "M.K. Kapral et al. / Women's Health Issues 21-2 (2011) 171–176 174 revascularization and lipid management observed in multiple previous studies of patients with myocardial infarction (Abramson Bierman et al., 2009; Jneid et al., 2008; Saposnik et al., 2009) as well as stroke (Lewsey et al., 2009; Reeves et al., 2009; Smith et al., 2009). Of note, recent work from our group suggests that some of the observed gender differences in carotid revascularization may be explained by appropriate patient selection based on stroke characteristics, surgical eligibility, and the prevalence of severe carotid stenosis (Kapral, Ben-Yakov, et al., 2009) For both women and men, older age was associated with lower rates of use of warfarin for atrial fibrillation, statin use, carotid imaging, and carotid endarterectomy, and higher rates of dysphagia screening and consultations from rehabilitation services, findings that are consistent with previous research (Fairhead & Rothwell, 2006; Kaplan et al., 2005). "
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