The Effect of a High-Intensity Interval Training Program on High-Density Lipoprotein Cholesterol in Young Men
This study examined the impact of an 8-week program of high-intensity interval training on high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and the atherogenic index (TC/HDL-C) in 36 untrained men ages 21-36 years. Participants were randomly assigned to an interval training group (n = 20) or a control group (n = 16). Participants in the experimental group performed 3.2 km of interval running (1:1 work:rest ratio) 3 times a week for 8 weeks at an intensity of 90% of maximal heart rate ( approximately 423 kcal per session). Results indicated significant pre- to posttraining changes in HDL-C (1.1 vs. 1.3 mmolxL, p < 0.0001) and TC/HDL-C (3.8 vs. 3.1, p < 0.0001) but no significant changes in TC (3.9 vs. 3.8 mmolxL, p > 0.05) with interval training. It was concluded that an 8-week program of high-intensity interval training is effective in eliciting favorable changes in HDL-C and TC/HDL-C but not TC in young adult men with normal TC levels. Our findings support the recommendations of high-intensity interval training as an alternative mode of exercise to improve blood lipid profiles for individuals with acceptable physical fitness levels.
Available from: Matthew D Barberio
- "Increases in the concentration of HDL in both the HIIT and ET groups (16 and 19 %, respectively) did not reach significance (HIIT p = 0.33; ET p = 0.08). However, the magnitude of increase was very similar to the significant increase (18 %, p < 0.05) measured by Musa et al. in a study that used a nearly identical training stimulus as our HIIT group: 8 weeks of HIIT 3 days per week, with work interval intensities of 90 % of VO 2max , a 1:1 work to rest ratio, and an energy expenditure of 1269 kcal week −1 (Musa et al. 2009). Farrell and Barboriak (1980) also found significant increases in HDL concentration (7 %) after 8 weeks of exercise training 3–4 days per week at an average intensity of 70 % of VO 2max . "
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The goal of this study was to compare the effect of work- and duration-matched interval training (HIIT) versus moderate aerobic endurance training (ET) on acute and chronic inflammation, along with changes in the lipid profile, to determine which may be more beneficial for improving cardiovascular health.
Twelve sedentary males (maximal oxygen consumption = 41.6 ± 5.4 mL kg(-1) min(-1)) completed 8 weeks of aerobic interval training or moderate aerobic training, with variables including C-reactive protein (CRP) for chronic inflammation, interleukin-6 (IL-6) response for the acute inflammatory response, plasma concentrations of high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TRG), and low-density lipoprotein, and body composition measured before and after the training period.
HIIT decreased plasma TRG from 92 ± 32 to 61 ± 12 mg dL(-1), which was significantly different from ET, while ET improved the TC:HDL ratio from 4.67 ± 0.85 to 4.07 ± 0.96 and reduced the percentage of android fat from 36.78 ± 9.60 to 34.18 ± 11.39 %. Neither training protocol resulted in an acute IL-6 response on the first nor the last day of exercise, a change in chronic levels of CRP, or a significant increase in HDL, despite previous research finding these changes.
It seems that in order to maximize the health outcomes from physical activity, both HIIT and ET should be included. The acute inflammatory response and reductions in chronic inflammation resulting from exercise training may not be as common as the literature suggests.
Available from: Shin-Hae Lee
- "The level of HDL-C was reported to increase by exercise training (Kodama et al. 2007; Musa et al. 2009), but the effect of exercise training on the level of total cholesterol is controversial (Durstine et al. 2001; Fahlman et al. 2002). In our experiments, both of the total cholesterol and HDL-C levels were increased through exercise training (Figure 2). "
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