... The most prominent ROH island revealed in this population was a putative signature of selection at BBU18, encompassing QTL and genes related to milk traits (APRT, ACSF3, FANCA, ANKRD11, and ZNF276; Cánovas et al., 2013;Zhao et al., 2015;Choudhary et al., 2018), immune system (CDH15 and CDK10; Makina et al., 2015;Ibeagha-Awemu et al., 2016), reproduction (SPATA33 and SPIRE2; Pfender et al., 2011;Chen et al., 2013), and coat pigmentation (TCF25, GAS8, VPS9D1, DBNDD1, and MC1R; Sulem et al., 2007;Branicki et al., 2009;Visser et al., 2012;Li et al., 2014;Kim et al., 2018;Nigenda-Morales et al., 2018;Grilz-Seger et al., 2019).The FANCA, AN-KRD11, and ZNF276 genes were previously identified in signatures of selection study in Holstein-Friesian cattle selected for milk production (Zhao et al., 2015), which lends support to the results obtained in this work. Some of the genes within the signature of selection signal on BBU18, including CDH15 and CDK10, have been previously associated with SCC, which is an important indicator of mammary gland health (Sharif and Muhammad, 2008;Chen et al., 2015). ...