Ultrasound-Mediated Drug/Gene Delivery in Solid Tumor Treatment

Division of Engineering Mechanics, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.
Journal of Healthcare Engineering (Impact Factor: 0.75). 06/2013; 4(2):223-54. DOI: 10.1260/2040-2295.4.2.223
Source: PubMed


Ultrasound is an emerging modality for drug delivery in chemotherapy. This paper reviews this novel technology by first introducing the designs and characteristics of three classes of drug/gene vehicles, microbubble (including nanoemulsion), liposomes, and micelles. In comparison to conventional free drug, the targeted drug-release and delivery through vessel wall and interstitial space to cancerous cells can be activated and enhanced under certain sonication conditions. In the acoustic field, there are several reactions of these drug vehicles, including hyperthermia, bubble cavitation, sonoporation, and sonodynamics, whose physical properties are illustrated for better understanding of this approach. In vitro and in vivo results are summarized, and future directions are discussed. Altogether, ultrasound-mediated drug/gene delivery under imaging guidance provides a promising option in cancer treatment with enhanced agent release and site specificity and reduced toxicity.

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Available from: Yufeng Zhou, Feb 03, 2015
    • "Modification of the pH of acidic organelles can reduce the sequestering effect for more penetration of tumor tissue and toxic effects in the cell nucleus (Ouar et al. 2003). The use of ultrasound energy to enhance the efficiency of chemotherapy of tumors began as early as the 1970s (Frenkel 2008;Zhou 2013). The cytotoxic effect of nitrogen mustard on mouse leukemia L1210 cells after sonication, without any mechanical damage to cells, was observed (Kremkau et al. 1976). "
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