The MLLgnant Consequences of Reverting to an Embryonic Transcriptional Program

Stem Cell Research Program, Division of Hematology/Oncology, Moores UCSD Cancer Center, University of California-San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.
Cell stem cell (Impact Factor: 22.27). 03/2009; 4(2):97-8. DOI: 10.1016/j.stem.2009.01.008
Source: PubMed


In this issue of Cell Stem Cell, Somervaille et al. (2009) have demonstrated convincingly that reversion to an embryonic transcriptional program through defective MLL gene expression contributes to the generation of myeloid leukemia stem cells.

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