Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training

Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden.
Science (Impact Factor: 33.61). 03/2009; 323(5915):800-2. DOI: 10.1126/science.1166102
Source: PubMed


Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.

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Available from: Torkel Klingberg
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    • "Dopamine transporters also correlated with deactivation in the default mode network on visual attention task [85] . Furthermore , changes in cortical dopamine D1 receptor binding observed by positron emission tomography were associated with improvement from CWMT [86]. Therefore, we expect cerebrospinal fluid monoamine and metabolite levels to be lower in HIV than in seronegative subjects at baseline, but levels may increase after CWMT. "

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    • "Cerebral regions involved in working memory tasks include bilateral medial posterior parietal cortex (BA 7, 40), bilateral premotor cortex (BA 6, 8), dorsal cingulate/medial premotor cortex (BA 6, 32), bilateral frontal poles (BA 10), bilateral dorsolateral prefrontal cortex (BA 9, 46) and bilateral frontal operculum (BA 45, 47) (Owen et al., 2005). Dopaminergic neurotransmission in the striatum has been found to be essential for adequate working memory performance (McNab et al., 2009) and impairments in working memory have been detected in de novo PD patients (Trujillo et al., 2015). Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of genetic parkinsonism (Singleton et al., 2012), the G2019S mutation being an important determinant of PD among both Ashkenazi Jews and North African Arabs (Ozelius et al., 2006; Thaler et al., 2009). "

    Full-text · Dataset · Dec 2015
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    • "Significant and lasting improvement in WM following working memory training has been reported in several populations with poor working memory skills, and transfer to some non-trained cognitive tasks has been observed (Klingberg et al., 2005; McNab et al., 2009; Olesen et al., 2004; Thorell et al., 2009; Westerberg and Klingberg, 2007; Westerberg et al., 2007). For example, Bickel et al. (2011) found that working memory training decreased delay discounting in stimulant users, suggesting greater preferences for larger-later rewards relative to smaller-sooner ones. "
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    ABSTRACT: Objective: Working memory impairment in individuals with chronic opioid dependence can play a major role in cognitive and treatment outcomes. Cognitive training targeting working memory shows promise for improved function in substance use disorders. To date, cognitive training has not been incorporated as an adjunctive treatment for opioid dependence. Methods: Methadone maintenance patients were randomly assigned to experimental (n=28) or active control (n=28) 25-session computerized training and run in parallel. Cognitive and drug use outcomes were assessed before and after training. Results: Participants in the experimental condition showed performance improvements on two of four working memory measures, and both groups improved on a third measure of working memory performance. Less frequent drug use was found in the experimental group than in the control group post-training. In contrast to previous findings with stimulant users, no significant effect of working memory training on delay discounting was found using either hypothetical or real rewards. There were no group differences on working memory outcome measures that were dissimilar from the training tasks, suggesting that another mechanism (e.g., increased distress tolerance) may have driven drug use results. Conclusions: Working memory training improves performance on some measures of working memory in methadone maintenance patients, and may impact drug use outcomes. Working memory training shows promise in patients with substance use disorders; however, further research is needed to understand the mechanisms through which performance is improved and drug use outcomes are impacted.
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