The Autism Brain Imaging Data Exchange: Towards Large-Scale Evaluation of the Intrinsic Brain Architecture in Autism

Article (PDF Available)inMolecular Psychiatry 19(6) · June 2013with250 Reads
DOI: 10.1038/mp.2013.78 · Source: PubMed
Autism spectrum disorders (ASDs) represent a formidable challenge for psychiatry and neuroscience because of their high prevalence, lifelong nature, complexity and substantial heterogeneity. Facing these obstacles requires large-scale multidisciplinary efforts. Although the field of genetics has pioneered data sharing for these reasons, neuroimaging had not kept pace. In response, we introduce the Autism Brain Imaging Data Exchange (ABIDE)-a grassroots consortium aggregating and openly sharing 1112 existing resting-state functional magnetic resonance imaging (R-fMRI) data sets with corresponding structural MRI and phenotypic information from 539 individuals with ASDs and 573 age-matched typical controls (TCs; 7-64 years) ( Here, we present this resource and demonstrate its suitability for advancing knowledge of ASD neurobiology based on analyses of 360 male subjects with ASDs and 403 male age-matched TCs. We focused on whole-brain intrinsic functional connectivity and also survey a range of voxel-wise measures of intrinsic functional brain architecture. Whole-brain analyses reconciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both were detected, although hypoconnectivity dominated, particularly for corticocortical and interhemispheric functional connectivity. Exploratory analyses using an array of regional metrics of intrinsic brain function converged on common loci of dysfunction in ASDs (mid- and posterior insula and posterior cingulate cortex), and highlighted less commonly explored regions such as the thalamus. The survey of the ABIDE R-fMRI data sets provides unprecedented demonstrations of both replication and novel discovery. By pooling multiple international data sets, ABIDE is expected to accelerate the pace of discovery setting the stage for the next generation of ASD studies.Molecular Psychiatry advance online publication, 18 June 2013; doi:10.1038/mp.2013.78.

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Available from: Julian Michael Tyszka
    • "@BULLET A child psychiatrist and a 3D video artist initiated a collaboration at the 2012 Brainhack to develop a movie to be shown to participants during resting-state fMRI scans to reduce head motion in hyperkinetic populations [5, 6]. @BULLET The ABIDE Preprocessing Initiative [7] is an ongoing project started at the 2012 Brainhack to share preprocessed versions of the Autism Brain Imaging Data Exchange (ABIDE) dataset [8, 9]. This project is sharing functional data that have been processed using the Connectome Computation System (CCS) [10, 11], the Configurable Pipeline for the Analysis of Connectomes (C-PAC) [12, 13], the Data Preprocessing Assistant for Resting State fMRI (DPARSF) [14, 15], and the Neuro Imaging Analysis Kit (NIAK) [16, 17], as well as cortical thickness measures extracted from structural data using FreeSurfer [18, 19], CIVET [20, 21], and Advanced Normalization Tools (ANTS) [22, 23]. "
    [Show abstract] [Hide abstract] ABSTRACT: Brainhack events offer a novel workshop format with participant-generated content that caters to the rapidly growing open neuroscience community. Including components from hackathons and unconferences, as well as parallel educational sessions, Brainhack fosters novel collaborations around the interests of its attendees. Here we provide an overview of its structure, past events, and example projects. Additionally, we outline current innovations such as regional events and post-conference publications. Through introducing Brainhack to the wider neuroscience community, we hope to provide a unique conference format that promotes the features of collaborative, open science.
    Full-text · Article · Dec 2016
    • "To explore sex-related differences in functional connectivity, we used resting-state fMRI data from males and females included in the Autism Brain Imaging Data Exchange repository (ABIDE) (Di et al., 2014).Table 1). Within each site, male participants (42 ASD, 75 TC) were selected to match the female participants pair-wise for age and IQ (Table 1). "
    [Show abstract] [Hide abstract] ABSTRACT: Autism spectrum disorders (ASD) are far more prevalent in males than in females. Little is known however about the differential neural expression of ASD in males and females.We used a resting-state fMRI-dataset comprising 42 males/ 42 females with ASD and 75 male/ 75 female typical-controls to examine whether autism-related alterations in intrinsic functional connectivity are similar or different in males and females, and particularly whether alterations reflect 'neural masculinization', as predicted by the Extreme Male Brain theory.Males and females showed a differential neural expression of ASD, characterized by highly consistent patterns of hypo-connectivity in males with ASD (compared to typical males), and hyper-connectivity in females with ASD (compared to typical females). Interestingly, patterns of hyper-connectivity in females with ASD reflected a shift towards the (high) connectivity levels seen in typical males (neural masculinization), whereas patterns of hypo-connectivity observed in males with ASD reflected a shift towards the (low) typical feminine connectivity patterns (neural feminization).Our data support the notion that ASD is a disorder of sexual differentiation rather than a disorder characterized by masculinization in both genders. Future work is needed to identify underlying factors such as sex hormonal alterations that drive these sex-specific neural expressions of ASD.
    Full-text · Article · Mar 2016
    • "Subjects All data included in this investigation came from the ABIDE which is described in detail in Di Martino et al. (2014). Briefly, the ABIDE is a publically available repository of structural MRI and resting-state fMRI data acquired on individuals with ASD and typically-developing (TD) individuals from 17 independent sites. "
    [Show abstract] [Hide abstract] ABSTRACT: Increased brain volume is a consistent finding in young children with autism spectrum disorders (ASD); however, the regional specificity and developmental course of abnormal brain structure are less clear. Small sample sizes, particularly among voxel-based morphometry (VBM) investigations, likely contribute to this difficulty. Recently established large-scale neuroimaging data repositories have helped clarify the neuroanatomy of neuropsychiatric disorders such as schizophrenia and may prove useful in ASD. Structural brain images from the Autism Brain Imaging Database Exchange (ABIDE), which contains over 1100 participants, were analyzing using DARTEL VBM to investigate total brain and tissue volumes, and regional brain structure abnormalities in ASD. Two, overlapping cohorts were analyzed; an ‘All Subjects’ cohort (n = 833) that included all individuals with usable MRI data, and a ‘Matched Samples’ cohort (n = 600) comprised of ASD and TD individuals matched, within each site, on age and sex. Total brain and grey matter volumes were enlarged by approximately 1–2 % in ASD; however, the effect reached statistical significance in only the All Subjects cohort. Within the All Subjects cohort, VBM analysis revealed enlargement of the left anterior superior temporal gyrus in ASD. No significant regional changes were detected in the Matched Samples cohort. There was a non-significant reduction in the correlation between IQ and TBV in ASD compared to TD. Brain structure abnormalities in ASD individuals age 6 and older consists of a subtle increase in total brain volume due to enlargement of grey matter with little evidence of regionally specific effects.
    Full-text · Article · Mar 2016
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