Fast Disinfecting Antimicrobial Surfaces

Department of Polymer Science & Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Langmuir (Impact Factor: 4.46). 02/2009; 25(2):1060-7. DOI: 10.1021/la802953v
Source: PubMed


Silicon wafers and glass surfaces were functionalized with facially amphiphilic antimicrobial copolymers using the "grafting from" technique. Surface-initiated atom transfer radical polymerization (ATRP) was used to grow poly(butylmethacrylate)-co-poly(Boc-aminoethyl methacrylate) from the surfaces. Upon Boc-deprotection, these surfaces became highly antimicrobial and killed S. aureus and E. coli 100% in less than 5 min. The molecular weight and grafting density of the polymer were controlled by varying the polymerization time and initiator surface density. Antimicrobial studies showed that the killing efficiency of these surfaces was independent of polymer layer thickness or grafting density within the range of surfaces studied.

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    • ") from the bacterial phospholipid membrane upon interactions with AMPs, leading to electrostatic imbalance on the membrane surface (Kugler et al., 2005; Madkour et al., 2009). This charge imbalance will alter the Donnan potential across the cytoplasmic membrane, which will ultimately trigger fatal cellular events such as the activation of autolytic enzymes or the disruption of electrostatic balance of internal layers (Hilpert et al., 2009). "
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    ABSTRACT: Not Available
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