Topical immunotherapy with diphenylcyclopropenone in vitiligo: A preliminary experience

Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran.
Indian journal of dermatology, venereology and leprology (Impact Factor: 1.39). 11/2008; 74(6):628-31. DOI: 10.4103/0378-6323.45108
Source: PubMed


Despite recent significant therapeutic advances, vitiligo remains a clinical conundrum. Topical immunotherapy has been extensively tested in the treatment of various dermatologic disorders, especially those believed to have an immunologic basis.
To evaluate the role of topical diphenylcyclopropenone (DPCP) in the treatment of vitiligo.
Nineteen patients with limited vitiligo lesions were enrolled in this study. After sensitization with 2% lotion of DPCP in acetone, progressively higher concentrations beginning at 0.001% up to 2% were applied weekly for 6 months to the depigmented skin lesions.
Thirteen of the 19 patients were evaluated at the end of 6 months. Four patients with focal vitiligo, one patient with vitiligo vulgaris, and three patients with segmental vitiligo showed marked (grade 3) repigmentation.
Marginal and central repigmentation with hyperpigmented borders was seen in the majority of lesions. Further controlled trials should be undertaken to evaluate the use of topical DPCP in vitiligo.

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