Surface-modified hydroxyapatite linked byL-lactic acid oligomer in the absence of catalyst

State Key Laboratory of Polymer Physics and Chemistry, Chinese Academy of Sciences, Peping, Beijing, China
Journal of Polymer Science Part A Polymer Chemistry (Impact Factor: 3.11). 11/2005; 43(21):5177-5185. DOI: 10.1002/pola.21006


A new surface modification method of hydroxyapatite nanoparticles (n-HA) by surface grafting reaction of L-lactic acid oligomer with carboxyl terminal (LAc oligomer) in the absence of any catalyst was developed. The LAc oligomer with a certain molecular weight was directly synthesized by condensation of L-lactic acid. Surface-modified HA nanoparticles (p-HA) were attested by Fourier transformation infrared spectroscopy, 31P MAS-NMR, and thermal gravimetric analysis (TGA). The results showed that LAc oligomer could be grafted onto the n-HA surface by forming a Ca carboxylate bond. The grafting amount of LAc oligomer was about 13.3 wt %. The p-HA/PLLA composites showed good mechanical properties and uniform microstructure. The tensile strength and modulus of the p-HA/PLLA composite containing 15 wt % of p-HA were 68.7 MPa and 2.1 GPa, respectively, while those of the n-HA/PLLA composites were 43 MPa and 1.6 GPa, respectively. The p-HA/PLLA composites had better thermal stability than n-HA/PLLA composites and neat PLLA had, as determined by isothermal TGA. The hydrolytic degradation behavior of the composites in phosphate buffered saline (PBS, pH 7.4) was investigated. The p-HA/PLLA composites lost their mechanical properties more slowly than did n-HA/PLLA composites in PBS because of their reinforced adhesion between the HA filler and PLLA matrix. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 5177–5185, 2005

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