Improvement of biochemical parameters in type 1 diabetic rats after the roots aqueous extract of yacon [Smallanthus sonchifolius (Poepp.& Endl.)] treatment

Residency Internal Medicine Departamento Clínica Médica/Faculdade de Medicina de Botucatu.
Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association (Impact Factor: 2.9). 06/2013; 59. DOI: 10.1016/j.fct.2013.05.050
Source: PubMed


The aim of this study was to evaluate the effect of yacon (Smallanthus sonchifolius)(Poepp.& Endl.) on clinical parameters under diabetic conditions. The aqueous extract of yacon tuberous roots (YRAE; 0.76g fructan kg(-1) body weight) was prepared at the moment of each administration. Thirty-two male rats were divided into four groups (n=8): control group (C); group that received YRAE (Y); untreated diabetic group (DM1); and diabetic group treated with YRAE (Y-DM1). The diabetes mellitus was induced by streptozotocin (60mg kg-1 body weight). The animals from Y2 and Y-DM1 received YRAE by gavage, at 7-day intervals, for 30 days. The aqueous extract of yacon roots decreased (p<0.05) the water and food intake in diabetic rats treated with YRAE (Y-DM1). YRAE treatment reduced (p<0.05) glycaemia, total cholesterol, VLDL, LDL and triacylglycerol levels in diabetic rats (YRAE). HDL, urea and creatinine levels did not differ (p>0.05) between the Y and Y-DM1 groups. YRAE normalised alanine aminotransferase (ALT) activity, when comparing DM1 and Y-DM1 rats, but had no effect on lactate dehydrogenase activity (LDH). In conclusion, YRAE was sufficient for controlling water and food consumption, hyperglycaemia and dyslipidaemia, and promote the reduction of the ALT, suggesting a hepatoprotective effect in rats with STZ-induced DM1.

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Available from: Camila Pereira Braga, Aug 27, 2014
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    ABSTRACT: Cashew-apple and yacon have been widely recognized as an excellent source of bioactive compounds, including prebiotics and antioxidants, which may be beneficial to health. Experimental data indicates that prebiotics and some specific polyphenols could reduce the severity or incidence of degenerative diseases, such as diabetics. The aim of this study was evaluate the hypoglycemic effect of a functional beverage composed of yacon and cashew-apple in alloxan-induced diabetic rats. The growth of lactobacilli in the cecal material, catalase activity in liver and antiproliferative activity using HepG2 cells were also evaluated. The total antioxidant capacity was determined in the beverage, showing values of 6.45 ± 0.40 μM Trolox ∙ g− 1 of fresh matter (FM), 15.58 ± 0.38 μM Fe2SO4 ∙ g− 1 of FM and 1780.14 ± 99.01 g of functional beverage ∙ g− 1of DPPH, measured by ABTS, FRAP and DPPH assays, respectively. The fructooligosaccharides (FOS) content (2.97 ± 0.07 FOS/100 mL) and total phenolic were determined (66.52 ± 1.17 mg gallic acid equivalent/100 g of FM), and the majoritarian phenolic compounds were identified by LC–DAD–ESI–MS. In the antiproliferative assay, HepG2 was significantly inhibited, in a dose-dependent manner, by exposure to the functional beverage. In addition, the functional beverage was tested in vivo. Male Wistar rats were divided into five groups: control, non-treated diabetic, and diabetic treated with 100, 200 or 400 mg of lyophilized functional beverage per kg/day. The results showed a decrease in the glucose levels, a promotion of the growth of lactobacilli in cecal material and an increase in catalase activity in the liver. The results strongly support that yacon and cashew-apple have important hypoglycemic properties that could ameliorate the diabetic state.
    Full-text · Article · Jul 2015 · Food Research International