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Catching function in action
Abstract
A major interest of Jörg is the establishment and sensible use of high-throughput analysis processes — with some emphasis on array-based assays — for the understanding and evaluation of the complex molecular interactions in living organisms.
... 36 Based on the abovementioned observation that the synergistic effect is present between different types of interactions, the question arises as to whether a cooperative effect can be found when anion-p and coinage metal-bonding interactions coexist in the same complex. Therefore, we selected three p-acidic hetero-aromatic compounds (1)(2)(3), as shown in Fig. 1, with substituent groups in the structures, which can act as electron donors in coinage metal-Lp interactions. Fig. 2 indicates the schematic of isolated anion-p (4-12) and metal-Lp (13)(14)(15)(16)(17)(18)(19)(20)(21) as well as anion-p-metal-Lp bonded complexes studied here. ...
This study investigates the interplay between the anion-π and coinage-metal-Lp interactions in complexes involving three hetero-aromatic compounds of pyrazine, 1,4-dicyanobenzene and 1,4-benzoquinone. The physical nature of both the interactions has been unveiled by means of the molecular electrostatic potential and energy decomposition. Interesting cooperativity effects are observed when the anion-π and coinage-metal-Lp interactions coexist in the same multicomponent. These effects have been theoretically studied in terms of energetic and geometric features of the complexes as well as the charge transfer and orbital interactions. Weaker anion-π interaction shows a greater enhancement in the presence of stronger metal-Lp interaction. In addition, experimental evidence for a combination of the two interactions was obtained from the Cambridge Structural Database.
While the deciphering of basic sequence information on a genomic scale is yielding
complete genomic sequences in ever-shorter intervals, experimental procedures for
elucidating the cellular effects and consequences of the DNA-encoded information
become critical for further analyses. In recent years, DNA microarray technology
has emerged as a prime candidate for the performance of many such functional
assays. Technically, array technology has come a long way since its conception some
15 years ago, initially designed as a means for large-scale mapping and sequencing.
The basic arrangement, however, could be adapted readily to serve eventually as an
analytical tool in a large variety of applications. On their own or in combination
with other methods, microarrays open up many new avenues of functional analysis.
Intermolecular interactions involving aromatic rings are key processes in both chemical and biological recognition. Their understanding is essential for rational drug design and lead optimization in medicinal chemistry. Different approaches-biological studies, molecular recognition studies with artificial receptors, crystallographic database mining, gas-phase studies, and theoretical calculations-are pursued to generate a profound understanding of the structural and energetic parameters of individual recognition modes involving aromatic rings. This review attempts to combine and summarize the knowledge gained from these investigations. The review focuses mainly on examples with biological relevance since one of its aims it to enhance the knowledge of molecular recognition forces that is essential for drug development.
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