Evaluation of Anxiety and Levels of Serum B12, Folate, TSH, Ferritin, and Zinc in Telogen Alopecia Patients with Trichodynia

ArticleinInternational Journal of Trichology 4(4):251-4 · October 2012with87 Reads
DOI: 10.4103/0974-7753.111208 · Source: PubMed
Trichodynia refers to pain, discomfort, and/or paresthesia of the scalp. Trichodynia may be associated with anxiety. To assess serum vitamin B12, folate, thyroid stimulating hormone (TSH), ferritin, and zinc levels, and to investigate anxiety in telogen alopecia patients with trichodynia. The study included 31 telogen alopecia patients who complained of trichodynia and 30 telogen alopecia patients without trichodynia. Their serum vitamin B12, folate, TSH, ferritin, and zinc levels were assessed and their anxiety levels were scored using the Beck Anxiety Inventory (BAI) and the State-Trait Anxiety Inventory (STAI). No significant difference was found in the serum levels of vitamin B12, folate, TSH, ferritin, and zinc in the patient and control groups. The anxiety scores in both groups were similar. Our data provide no evidence for the association of serum vitamin B12, folate, TSH, ferritin, and zinc levels or anxiety scores with trichodynia.


  • [Show abstract] [Hide abstract] ABSTRACT: Introduction: In women receiving antineoplastic therapy, hair loss is often accompanied by distressing hair or scalp sensations, such as hair pain (trichodynia) and pruritus. A scientific approach to objectively evaluate the course and characteristics of these unpleasant sensations is of great importance for the establishment of treatment strategies. Methods: An observational cohort study was conducted in 34 female breast cancer patients, postoperatively undergoing chemotherapy (group C, n = 17) or endocrine therapy with tamoxifen (group T, n = 17). For 28 weeks after therapy initiation, patients experiencing hair pain and/or scalp pruritus were required to complete a specially developed diary, based on a modification of pain questionnaires. Sensations were journalized in terms of time of onset, duration, intensity on a numeric rating scale, dependence on touching the scalp or hair and character of the sensation, chosen from given descriptors or using own words. Results: In group C, all patients who completed the questionnaire experienced hair and scalp sensations: 87% both trichodynia and pruritus, 13% trichodynia only. Reported intensities ranged between 1 and 10. In group T, 31% of participants reported hair and scalp sensations: 12% both trichodynia and pruritus, 12% pruritus only, 7% trichodynia only. Intensities were rated between 1 and 5. No sensations were reported after week 11 in either group. Conclusions: Hair and scalp sensations in group C were significantly more common, lasted longer, and were of greater intensity and more differentiated qualities than in group T. The occurrence of trichodynia in chemotherapy patients corresponded with the onset and duration of hair loss, thus suggesting a possible correlation.
    Article · Sep 2015
    V KantiV KantiR NuwayhidR NuwayhidJ LindnerJ Lindner+1more author...[...]
  • [Show abstract] [Hide abstract] ABSTRACT: Trichodynia designates a painful sensation on the scalp sometimes reported by patients with hair loss. Its best description dates back to 1960, when Sulzberger et al. (Arch Dermatol 1960; 81: 556-560) reported it in a proportion of women complaining of an unexplained diffuse alopecia. Sulzberger et al.'s remark that trichodynia may also be circumscribed ("spotty") is an important detail missed by most ensuing observers. Women are mostly affected or, at least, more likely to report it. The quality and intensity vary greatly, the "burning" variety being most severe. Whether trichodynia is prevalent in telogen effluvium or it may also be present in androgenetic alopecia remains a crucial question. Hairs shed only from painful sites, and this observation suggests that the severity of trichodynia is directly related to hair shedding and intensity. Trichodynia seems to be related to the release of substance P and is present in alopecia areata. Both observations suggest that peripilar inflammation may be a causative agent.
    Full-text · Article · Dec 2015

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