A large cellular angiofibroma of the male pelvis presenting with obstructive voiding: A case report and review of the literature

Department of Urology, University of South Florida, Tampa, FL
Canadian Urological Association journal = Journal de l'Association des urologues du Canada (Impact Factor: 1.92). 05/2013; 7(5-6):E373-5. DOI: 10.5489/cuaj.1222
Source: PubMed


Cellular angiofibromas (CAF) are rare, benign soft-tissue tumours. The diagnosis of CAF is important given the heavy resemblance to other tumours. Herein, we describe a case of a rapidly growing, very large (13.5 cm) CAF located in the deep pelvis of a middle-aged male who presented with difficulty voiding.

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Available from: David J Hernandez, Jan 19, 2016
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    • "Since then, similar lesions have been described in the inguinoscrotal region of men, originally labeled as “angiomyofibroblastoma-like tumor of the male genital tract” [1, 2]. Different case reports reveal similar lesions in other sites: subcutaneous tissue of the chest wall [3], male pelvis [4], and oral mucosa [5], but an intraprostatic location was hitherto unreported. "
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    ABSTRACT: We report the unusual occurrence of a cellular angiofibroma in prostatic tissue. In this case, a 84-year-old man presented in the emergency room with urinary retention. Ultrasound revealed an enlarged prostate, which was suggestive for benign prostatic hyperplasia. The patient was treated with a Millin retropubic prostatectomy. Macroscopically the prostate contained multiple circumscribed nodules. Microscopic examination of the tumor showed the appearance of cellular angiofibroma, consisting of bland spindle cells and prominent, hyalinized vessels. The diagnosis was supported by FISH, which revealed monoallelic loss of RB1 /13q14 region, as seen in spindle cell lipoma, (extra-) mammary myofibroblastoma, and cellular angiofibroma. Cellular angiofibromas are rare, benign soft tissue tumours and were never reported in the prostatic gland.
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