Limited utility of serum galactomannan assay after auto-SCT

1From the Infectious Disease Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Bone marrow transplantation (Impact Factor: 3.57). 02/2009; 44(1):59-61. DOI: 10.1038/bmt.2008.425
Source: PubMed


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    • "Elevated levels of galactomannan have been detected at early stages of fungal infections, however , the sensitivity and specificity of this assay has been criticized [36]. Moreover, the galactomannan assay is not useful for other fungal pathogens, including Candida [30] [37]. β-1,3-glucan serological detection assays are more widely used today because they can detect a wide range of fungi, including Aspergillus and Candida, but they do not detect zygo-or mucormycosis or cryptococcal disease [38]. "
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    ABSTRACT: The human immune system is capable of recognizing and degrading chitin, an important cell wall component of pathogenic fungi. In the context of host-immune responses to fungal infections, herein we review the particular contributions and interplay of fungus and chitin recognition, and chitin-degrading enzymes, known as chitinases. The mechanisms of host chitinase responses may have implications for diagnostic assays as well as novel therapeutic approaches for patients that are at risk of contracting fatal fungal infections.
    Full-text · Article · Jan 2012 · International Journal of Microbiology