Is a Booster Dose Necessary in Children after Immunization with Live Attenuated Japanese Encephalitis Vaccine?

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Journal of Tropical Pediatrics (Impact Factor: 1.26). 06/2013; 59(5). DOI: 10.1093/tropej/fmt043
Source: PubMed


Japanese encephalitis virus is a common cause of encephalitis in Asian children; therefore, maintenance of immunity against
Japanese encephalitis virus is essential. Although many countries recommend booster vaccination, some trials have concluded
that administration of one or two vaccinations is sufficient. The current study was conducted to evaluate immunogenicity and
safety after a booster vaccination with live attenuated vaccine. For 68 study subjects, measurement of antibody titer was
performed before and at 4–6 weeks after administration of a booster dose. Adverse reactions occurring at the injection site
and systemic adverse reactions were documented. The percentages of subjects with seroprotective neutralizing antibody titers
was 100% before and after booster vaccination, and the geometric mean titer increased after booster vaccination. Thus, we
predict that immunity will be maintained for a long time by an amnestic response. Low percentages of adverse reactions indicated
the safety of the immunizations.

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    ABSTRACT: A number of Japanese encephalitis (JE) vaccines have been used for preventing Japanese encephalitis around the world. We here reviewed the immunogenicity and safety of the currently available Japanese encephalitis vaccines. We searched Pubmed, Embase, Web of Science, the Cochrane Library and other online databases up to March 25, 2014 for studies focusing on currently used JE vaccines in any language. The primary outcomes were the seroconversion rate against JEV and adverse events. Meta-analysis was performed for the primary outcome when available. A total of 51 articles were included. Studies were grouped on the basic types of vaccines. This systematic review led to 2 aspects of the conclusions. On one hand, all the currently available JE vaccines are safe and effective. On the other hand, the overall of JE vaccine evaluation is disorganized, the large variation in study designs, vaccine types, schedules, doses, population and few hand-to-hand trails, make direct comparisons difficult. In order to make a more evidence-based decision on optimizing the JE vaccine, it is warranted to standardize the JE vaccine evaluation research.
    No preview · Article · Dec 2014 · Human Vaccines and Immunotherapeutics