Oestrogen receptor-β1 but not oestrogen receptor-βcx is of prognostic value in apocrine carcinoma of the breast

ArticleinApmis 116(10):923-30 · November 2008with8 Reads
DOI: 10.1111/j.1600-0463.2008.01122.x · Source: PubMed
Apocrine carcinoma of the breast, which frequently expresses oestrogen receptor-beta (ER-beta) in the absence of ER-alpha and only infrequently is treated endocrinologically, gives an opportunity to investigate the clinicopathological role of ER-beta in breast cancer independent of ER-alpha expression or tamoxifen treatment. Several isotypes of ER-beta, ER-beta1-5 etc., have been identified thus far; however, the clinicopathological importance of each ER-beta isotype in breast cancer is still uncertain. Here we aimed to clarify the clinicopathological importance of ER-beta1 and ER-betacx (ER-beta2) in apocrine carcinomas, immunohistochemically examining expressions of ER-beta1 and ER-betacx in 47 apocrine carcinomas. Positivity for ER-beta1 and ER-betacx was observed in 41 (87%) and 18 (38%) of 47 cases, respectively. ER-beta1 positivity was related to smaller tumor size (P=0.0359), lower histological grade (P=0.0322), and higher disease-free survival (P<0.0001), whereas ER-betacx status was related to none of these parameters. ER-beta1 positivity was also associated with favorable clinical outcome in 24 so-called triple-negative (ER-alpha-negative/PR-negative/HER2-negative) apocrine carcinomas. ER-beta1 itself, independent of ER-alpha expression and tamoxifen treatment, seems to have a tumor-suppressive effect, at least in apocrine carcinomas. Further study of ER-beta1 is desired to optimize breast cancer treatment.
    • "The majority of TNBCs are from the basal-like subtype (~70%) [7] and express basal-type cytokeratin 5 and cytokeratin 6, as well as high expression of the epidermal growth factor receptor (EGFR) [8]. Most TNBCs are classed as invasive ductal carcinomas, nevertheless a high proportion of other histology types are ER, PR, and HER2 negative including metaplastic carcinomas [9,10] and apocrine carcinomas [11]. TNBC accounts for only 10%–17% of all breast cancer patients [12]. "
    [Show abstract] [Hide abstract] ABSTRACT: Triple negative breast cancer (TNBC) is characterised by the lack of receptors for estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER2). Since it cannot be treated by current endocrine therapies which target these receptors and due to its aggressive nature, it has one of the worst prognoses of all breast cancer subtypes. The only treatments remain chemo- and/or radio-therapy and surgery and because of this, novel biomarkers or treatment targets are urgently required to improve disease outcomes. MicroRNAs represent an attractive candidate for targeted therapies against TNBC, due to their natural ability to act as antisense interactors and regulators of entire gene sets involved in malignancy and their superiority over mRNA profiling to accurately classify disease. Here we review the current knowledge regarding miRNAs as biomarkers in TNBC and their potential use as therapeutic targets in this disease. Further, we review other epigenetic changes and interactions of these changes with microRNAs in this breast cancer subtype, which may lead to the discovery of new treatment targets for TNBC.
    Full-text · Article · Nov 2015
    • "In general, ERb1 expression correlates with ERa expression, small tumor size, low histological grade and lymph node negativity (Table 1)(Honma et al., 2008b; Marotti et al., 2010; Nakopoulou et al., 2004; Sugiura et al., 2007) and inversely correlates to HER2 expression (Marotti et al., 2010; Myers et al., 2004; Nakopoulou et al., 2004). In a study encompassing 2170 breast cancer patients, ERb1 expression correlated to ERa expression and inversely correlated to HER2 expression. "
    [Show abstract] [Hide abstract] ABSTRACT: Estrogen is essential for growth and development of the mammary glands and has been associated with the promotion and growth of breast cancer and in line with this, most human breast cancers are initially estrogen-dependent and undergo regression when deprived of their supporting hormone. Estrogen exerts many of its effects via two nuclear estrogen receptors (ERs), ERα and ERβ. The discovery of a second ER, ERβ, demanded a full re-evaluation of estrogen action in all target tissues and different estrogen associated diseases, including human breast cancer. However, despite over 15 years of research, the exact role, if any, of ERβ in human breast cancer remains elusive. The main challenges now are to develop highly selective anti-ERβ antibodies that are applied to large well characterized human breast cancer samples to validate their diagnostic potential and to explore ERβ-selective agonists in animal models of breast cancer to validate their therapeutic potential.
    Full-text · Article · Jan 2014
    • "Estrogen receptor-beta (ER-beta) which shares a high degree of amino acid homology with ER-alpha66 has been found overexpressed in ER-alpha66 negative breast carcinomas including invasive apocrine carcinoma of the breast (Sakamoto and Honma, 2009; Yan et al., 2011). Honma et al. showed the presence of ER-beta and ER-beta1 isoforms in apocrine carcinoma with beta1 isoform exhibiting a favorable prognostic value in invasive apocrine carcinoma (Honma et al., 2007Honma et al., , 2008). The precise role of ER-beta in apocrine carcinoma remains to be determined. "
    [Show abstract] [Hide abstract] ABSTRACT: Apocrine carcinoma of the breast is a rare, special type of breast carcinoma showing distinct morphologic, immunohistochemical and molecular genetic features. Apocrine epithelium has a characteristic steroid receptor profile that is estrogen receptor and progesterone receptor negative and androgen receptor positive. This combination of morphologic and immunohistochemical characteristics is essential for the proper recognition of the apocrine carcinomas. Strictly defined, apocrine carcinomas express either Her-2/neu or EGFR, which along with androgen receptor positivity make patients with the apocrine carcinoma eligible for targeted therapies.
    Full-text · Article · Jun 2013
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