One of the successful precast concrete systems that has emerged from the PRESSS (PREcast Seismic Structural Systems) research program is the unbonded post-tensioned concrete wall system. This paper addresses the use of these walls with rectangular openings to accommodate architectural, mechanical, and safety requirements. The openings can cause large tensile stresses and, thus, cracking in the wall panels. Little information is available to aid in the design of the panel reinforcement around the openings to limit the size of these cracks. This paper describes an analytical investigation of the behavior and design of the walls under vertical post-tensioning and gravity loads. Critical regions in the wall panels where bonded mild steel reinforcement is needed are identified and a design approach is proposed to determine the required panel reinforcement. The effects of opening length, opening height, wall length, and initial stress in the concrete due to post-tensioning and gravity loads are considered. An example is included to demonstrate the proposed design approach.