Results of Intratympanic Dexamethasone Injection as Salvage Treatment in Idiopathic Sudden Hearing Loss

Department of Otorhinolaryngology, Head and Neck Surgery, Pundang Jesaeng Hospital, Daejin Medical Center, Sungnam, Korea.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (Impact Factor: 0.89). 04/2008; 37(2):263-8. DOI: 10.2310/7070.2008.0055
Source: PubMed


To evaluate the efficacy of intratympanic (IT) dexamethasone injection as a salvage treatment in idiopathic sudden hearing loss (ISHL) patients.
A prospective study.
A secondary care hospital.
Fifty-two subjects whose pure-tone averages (PTAs) after a 2-week standard treatment were > 30 dB or worse than 10 dB from the contralateral ear were included. Thirty-four patients underwent IT dexamethasone injection and 18 patients (control) received no further treatment. Final hearing outcome was compared between the two groups.
At 2 weeks after IT dexamethasone injection, audiograms were obtained and compared between the two groups.
Sixteen patients (47.1%) in the IT dexamethasone group and 8 patients (44.4%) in the control group finally showed an improvement of 10 dB or more in PTA or a 15% or more change in speech discrimination score (p > .05). The average improvement in PTAs was 8.2 dB in the IT dexamethasone group and 3.6 dB in the control group (p = .184). Patients responsive to the initial treatment showed better final outcomes, irrespective of IT dexamethasone injection.
The present study does not support IT dexamethasone injection as a beneficial salvage treatment for ISHL patients. The true efficacy of this procedure still needs to be investigated.

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