Brain activations in errorless and errorful learning in patients with diffuse axonal injury: A functional MRI study

Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan.
Brain Injury (Impact Factor: 1.81). 04/2009; 23(4):291-8.. DOI: 10.1080/02699050902794855.
Source: OAI


Errorless learning has been reported to be effective in the rehabilitation of patients with impaired cognitive functions following brain injury. This study compared brain activations in errorless learning (EL) and errorful learning (EF) in patients with diffuse axonal injury (DAI) using a functional magnetic resonance imaging (fMRI).
The participants were 13 patients with DAI. Thirteen healthy individuals were evaluated as a control group. The participants learned words under the EL and EF conditions in advance and performed the recognition task during fMRI scanning.
EL in the control group was significantly faster than EF (p = 0.005), but not in the DAI group. EL in the DAI group scored significantly higher than EF (p = 0.026). An fMRI showed significant activations in the posterior cingulate gyrus (BA 31) and precuneus (BA 7) in the control group when EF > EL, but in the precuneus (BA 7, 31) and bilateral inferior parietal lobules (BA 39, 40) in the DAI group.
These results indicate the disadvantage of EF and advantage of EL to DAI patients. The findings also reflect brain plasticity in patients with DAI in the chronic phase.

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Available from: Hiroki Ueno
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    • "Therapeutic activities include those similarly used in cognitive rehabilitation (Cappa et al., 2005; Helmick, 2010), such as process, strategy and functional training activities, errorless learning, and awareness training (Golisz, 2009; Malia et al., 2004; Ueno et al., 2009). Other goals include increasing tactile sensitivity and other visual-spatial, tactilekinesthetic , and fine motor skills. "

    Preview · Article · Jan 2016
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    • "Rodriguez- Fornells, Kofidis, and Münte (2004) conducted an electroencephalography study, and found error-related negativity, a waveform deflection that is maximal over central frontal regions when an error or mismatch is detected or signalled by feedback (Holroyd & Coles, 2002; Scheffers & Coles, 2000), elicited when participants make recognition decisions about learning errors and targets learned through errorful learning. Ueno et al. (2009) conducted a functional magnetic resonance imaging study of errorless and errorful learning in a group of patients with diffuse axonal injury and healthy controls. Consistent with the Rodriguez-Fornells study, they found greater activation of the anterior cingulate during errorful than errorless learning, but only in the control group. "

    Full-text · Dataset · Aug 2014
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    • "So far, there is only one fMRI study investigating the advantages of EL learning and the disadvantages of EF learning in a word stem completion task in patients with diffuse axonal injury in a blocked design [37]. Due to the blocked design, the the findings are insensitive to the correctness of the response. "
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    ABSTRACT: Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related functional magnetic resonance imaging (fMRI) was used to contrast errorless and errorful learning. Learning mode was manipulated by the number of distractors during learning of face-name associations: in errorless learning only the correct name was introduced. During errorful learning either one incorrect name or two incorrect names were additionally introduced in order to modulate the interference in recognition. The behavioural results showed an enhanced memory performance after errorless learning. The veridicality of recognition of the face-name associations was reflected in a left lateralized fronto-temporal-parietal network. The different learning modes were associated with modulations in left prefrontal and parietal regions. Errorless learning enhances memory performance as compared to errorful learning and underpins the known advantages for errorless learning. During memory retrieval different networks are engaged for specific purposes: Recognition of face-name associations engaged a lateralized fronto-temporal-parietal network and executive monitoring processes of memory engaged the left prefrontal and parietal regions.
    Full-text · Article · Mar 2013 · BMC Neuroscience
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