Generalized eruptive keratoacanthomas of Grzybowski treated with isoretinoin

Presbyterian- St. Luke's Hospital, Denver, CO, USA.
Journal of drugs in dermatology: JDD (Impact Factor: 1.45). 12/2008; 7(11):1069-71.
Source: PubMed


Generalized eruptive keratoacanthomas of Grzybowski is a rare condition of unknown etiology. The disease is characterized by the abrupt onset of many small crateriform papules on the skin and mucous membranes. The authors report of a man with multiple eruptive keratoacanthomas of Grzybowski who responded favorably to oral isotretinoin therapy. After 2 years of follow-up, a complete regression of all lesions was observed, and this rapid clearance under isotretinoin therapy is intriguing with regard to the possible etiology of the condition.

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