Presence of Antibodies against Genogroup VI Norovirus in Humans

Virology Journal (Impact Factor: 2.18). 06/2013; 10(1):176. DOI: 10.1186/1743-422X-10-176
Source: PubMed


Noroviruses are important enteric pathogens in humans and animals. Recently, we reported a novel canine norovirus (CaNoV) in dogs with diarrhea belonging to a new genogroup (GVI). No data are available on exposure of humans to this virus.

Sera from 373 small animal veterinarians and 120 age-matched population controls were tested for IgG antibodies to CaNoV by a recombinant virus like particle based enzyme-linked immunosorbent assay.

Antibodies to CaNoV were found in 22.3% of the veterinarians and 5.8% of the control group (p < 0.001). Mean corrected OD450 values for CaNoV antibodies were significantly higher in small animal veterinarians compared to the control group.

These findings suggest that CaNoV may infect humans and small animal veterinarians are at an increased risk for exposure to this virus. Additional studies are needed to assess if this virus is able to cause disease in humans.

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Available from: Jan Vinjé
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    • "For example, HuNVs can infect gnotobiotic piglets (Cheetham et al., 2006) and there is serological evidence of HuNV in pigs (Farkas et al., 2005). Whilst antibodies to GVI noroviruses have been identified in veterinarians, it has yet to be determined whether infection results in clinical disease (Mesquita et al., 2013). Additional studies are required to further elucidate the zoonotic potential of noroviruses and whether animals represent a reservoir from which new strains may emerge. "
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