TALINUM PANICULATUM (JACQ.) GERTN: A MEDICINAL PLANT WITH POTENTIAL ESTROGENIC ACTIVITY IN OVARIECTOMIZED RATS
Objective: Talinum paniculatum (Jacq.) Gertn (T. paniculatum), is extensively used in Asian traditional medicine as a reproductive tonic. However, there is no conclusive scientific data to support this practice. This study was conducted to explore the possible estrogenic activity of T. paniculatum extracts compared with 17ß-estradiol (E2) in adult bilaterally ovariectomized (OVX) rats for the experimental model of menopause. Methods: OVX female Wistar rats were randomly divided into six groups. The first group was orally treated with sesame oil as a vehicle control. The other six groups were treated with different treatments consisted of the groups which were treated by a positive standard control of 17ß-estradiol (10μg. kg-1BW), T. paniculatum root or leaf extract at two different doses (100 and 1,000 mg.kg-1BW) for 42 consecutive days, respectively. Estrogenic activity was evaluated by determining the vaginal cornification, relative uterine weight (%RU), relative mammary weight (%RM), and their histoarchitecture changes. Results: T. paniculatum root and leaf extracts significantly increased the vaginal cornification (P<0.001). Compared to OVX control, a dose dependency response of %RU, %RM and proliferative changes in vagina, uterus and mammary ductular tissue were significantly observed in OVX treated with all dosages of T. paniculatum from root and leaf extracts (P<0.05). Conclusion: T. paniculatum extracts possess estrogenic activity in the OVX rats, which can be helpful in managing reproductive tissues regression during menopause in a natural way through herbal resources without any toxicity.