The Generation R Study: Design and cohort update until the age of 4 years

The Generation R Study Group (AE006), Erasmus Medical Center, Rotterdam, The Netherlands.
European Journal of Epidemiology (Impact Factor: 5.34). 01/2009; 23(12):801-11. DOI: 10.1007/s10654-008-9309-4
Source: PubMed


The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participate in the study. In addition, more detailed assessments are conducted in a subgroup of 1,232 pregnant women and their children. Data collection in the prenatal phase and postnatal phase until the age of 4 years includes questionnaires, detailed physical and ultrasound examinations, behavioural observations and biological samples. This paper gives an update of the study design and cohort profile until the children's age of 4 years. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

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    • "r Langeslag et al. r r 2 r adulthood in Rotterdam, The Netherlands [Jaddoe et al., 2008, 2010] "
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    • "This study was embedded within the Generation R Focus Study, a cohort study investigating growth, development, and health from fetal life into young adulthood in Rotterdam, the Netherlands. The cohort has been described in detail elsewhere (Jaddoe et al., 2008). The Generation R Focus Study, a subgroup within the Generation R Study, is conducted to obtain detailed measurements of the child's development in an ethnically homogeneous subgroup to exclude confounding or effect modification by ethnicity. "
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    • "This research was conducted within the Generation R Focus Study, a population-based cohort from fetal life onwards, in Rotterdam, the Netherlands (Jaddoe et al., 2008). In order to exclude confounding and effect modification by ethnicity, the participants of the focus study were ethnically homogeneous (indigenous Dutch). "
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