Cold atmospheric plasma devices for medical issues

Department of Dermatology, Allergology and Environmental Medicine, Hospital Munich Schwabing, Koelner Platz 1, Munich 80804, Germany.
Expert Review of Medical Devices (Impact Factor: 1.68). 05/2013; 10(3):367-77. DOI: 10.1586/erd.13.4
Source: PubMed


Cold atmospheric plasma science is an innovative upcoming technology for the medical sector. The plasma composition and subsequent effects on cells, tissues and pathogens can vary enormously depending on the plasma source, the plasma settings and the ambient conditions. Cold atmospheric plasmas consist of a highly reactive mix of ions and electrons, reactive molecules, excited species, electric fields and to some extent also UV radiation. In the last year, this partly ionized gas has been demonstrated to have a broad antimicrobial activity, while resistance and resistance development are unlikely. Furthermore, recent research has indicated that plasmas also have a strong influence on various cell lines and cell functions, including anticancer properties. This review summarizes the major plasma designs available and their main benefits, as well as assessing possible risks of this new technology.

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    • "Plasma, which is one of the fourth fundamental states of matter (besides solid, liquid, and gas), is clean and environmentally-friendly. It has been introduced as an approach useful in modification of the surface materials, decontamination of micro-organism, and treatment of diseases [6] [7] [8]. Recently, plasma has been applied to accelerate seed germination [9]. "
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    ABSTRACT: This is the first study to apply plasma technology for improving nutrition value of cereal products. Cold plasma, a mixture of oxygen and argon plasma, was applied to rice seeds before pre-germination process. Plasma condition of 10 watts, 5 seconds, and 5 millimeters distance and 10 watts, 5 seconds, and 8 millimeters distance created high germination rates of pre-germinated brown rice. The latter conditions gave the grains with longer roots and bodies. Plasma treatment could result in increasing contents of total phenolics and γ-aminobutyric acid. Gas chromatography-mass spectrometry revealed 13 identifiable compounds: simple phenolic compounds; pyrans; furan; quinone; and fatty acids, in which biosyntheses of these 13 compounds were likely to be promoted by the plasma processing. These findings suggest that plasma technology could provide better quality pre-germinated brown rice.
    Full-text · Article · Nov 2014 · Journal of food and nutrition research
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    ABSTRACT: Following surgery of cholesteatoma, a patient developed a chronic infection of the external auditory canal, including extended-spectrum β-lactamase producing Escherichia coli, which caused severe pain. The application of cold atmospheric plasma resulted in a significant reduction in pain and clearance of bacterial carriage, allowing antibiotics and analgesics to be ceased.
    Full-text · Article · Dec 2013
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    ABSTRACT: "Plasma oncology", i.e., the use of cold atmospheric plasma (CAP) for the treatment of tumours is a new field in plasma medicine. The results of several studies that are summarized within this review show that CAP is effective against tumour cells both in vitro and in vivo. It has been shown, that CAP in low concentration is able to stop tumour cells growing, to induce cell death in higher concentrations and that this is more effective than standard therapies. Moreover, first results indicate that CAP seems to be selective for cancer cells since it is more effective in tumour cells than in normal non-neoplastic cells. The current developments in this field have fuelled the hope that CAP could be an interesting new therapeutic approach in the treatment of cancer.
    No preview · Article · Dec 2013 · Clinical Plasma Medicine
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