ArticlePDF AvailableLiterature Review

Abstract and Figures

Athletes are among the groups of people who are interested in the effects of caffeine on endurance and exercise capacity. Although many studies have investigated the effect of caffeine ingestion on exercise, not all are suited to draw conclusions regarding caffeine and sports performance. Characteristics of studies that can better explore the issues of athletes include the use of well-trained subjects, conditions that reflect actual practices in sport, and exercise protocols that simulate real-life events. There is a scarcity of field-based studies and investigations involving elite performers. Researchers are encouraged to use statistical analyses that consider the magnitude of changes, and to establish whether these are meaningful to the outcome of sport. The available literature that follows such guidelines suggests that performance benefits can be seen with moderate amounts (~3 body mass) of caffeine. Furthermore, these benefits are likely to occur across a range of sports, including endurance events, stop-and-go events (e.g., team and racquet sports), and sports involving sustained high-intensity activity lasting from 1-60 min (e.g., swimming, rowing, and middle and distance running races). The direct effects on single events involving strength and power, such as lifts, throws, and sprints, are unclear. Further studies are needed to better elucidate the range of protocols (timing and amount of doses) that produce benefits and the range of sports to which these may apply. Individual responses, the politics of sport, and the effects of caffeine on other goals, such as sleep, hydration, and refuelling, also need to be considered.
Content may be subject to copyright.
Caffeine and sports performance
Louise M. Burke
Abstract: Athletes are among the groups of people who are interested in the effects of caffeine on endurance and exercise
capacity. Although many studies have investigated the effect of caffeine ingestion on exercise, not all are suited to draw
conclusions regarding caffeine and sports performance. Characteristics of studies that can better explore the issues of ath-
letes include the use of well-trained subjects, conditions that reflect actual practices in sport, and exercise protocols that
simulate real-life events. There is a scarcity of field-based studies and investigations involving elite performers. Research-
ers are encouraged to use statistical analyses that consider the magnitude of changes, and to establish whether these are
meaningful to the outcome of sport. The available literature that follows such guidelines suggests that performance benefits
can be seen with moderate amounts (~3 mgkg–1 body mass) of caffeine. Furthermore, these benefits are likely to occur
across a range of sports, including endurance events, stop-and-go events (e.g., team and racquet sports), and sports involv-
ing sustained high-intensity activity lasting from 1–60 min (e.g., swimming, rowing, and middle and distance running
races). The direct effects on single events involving strength and power, such as lifts, throws, and sprints, are unclear. Fur-
ther studies are needed to better elucidate the range of protocols (timing and amount of doses) that produce benefits and
the range of sports to which these may apply. Individual responses, the politics of sport, and the effects of caffeine on
other goals, such as sleep, hydration, and refuelling, also need to be considered.
Key words: ergogenic aid, sports performance, doping.
´:Les athle
`tes font partie des gens concerne
´s par les effets de la cafe
´ine sur l’endurance et la capacite
ˆme si de nombreuses e
´tudes ont porte
´sur les effets de la consommation de la cafe
´ine sur l’exercice physique, elles ne
permettent pas toutes de tirer des conclusions au sujet des effets de la cafe
´ine sur la performance sportive. Pour analyser
de tels effets, il faut des e
´tudes incluant des sujets bien entraı
´s, des conditions refle
´tant les pratiques sportives en cours
et des protocoles expe
´rimentaux simulant des conditions re
´elles. Il y a tre
`s peu d’e
´tudes re
´es sur le terrain qui incluent
des athle
`tes d’e
´lite. On invite les chercheurs a
`utiliser des outils statistiques mesurant l’importance des variations notam-
ment sur le plan de la pertinence dans la pratique sportive. Les e
´tudes scientifiques qui prennent en compte ces directives
rapportent qu’une quantite
´e de cafe
´(~3 mgkg–1 de masse corporelle) suscite des gains sur le plan de la perfor-
mance. De plus, ces gains devraient se manifester dans un large spectre d’activite
´s sportives dont les activite
´s d’endurance,
les activite
´s constitue
´es d’arre
ˆts et de de
´parts tels les sports d’e
´quipe et de raquette et les activite
´s demandant une forte in-
´soutenue de 1 min a
`60 min comme la natation, l’aviron, la course de demi-fond et de fond. Les effets directs de la
consommation de cafe
´ine dans les activite
´s de force et de puissance tels les levers, les lancers et les sprints ne sont pas
bien e
´tablis. Il faut faire d’autres e
´tudes pour bien de
´terminer les varie
´s de protocoles admissibles (moment de l’anne
´e) qui suscitent des gains et qui identifient les sports pouvant en be
´ficier. Il faut aussi faire d’autres
´tudes sur les re
´ponses individuelles, les politiques du sport et sur les effets de la cafe
´ine sur d’autres facteurs tels le som-
meil, l’hydratation et la recharge d’e
´s:facteur ergoge
`ne, performance sportive, dopage.
[Traduit par la Re
Caffeine is a drug that enjoys social acceptance and wide-
spread use around the world, with about 90% of adults con-
suming it in their everyday eating patterns. The effects of
caffeine in reducing fatigue and increasing wakefulness and
alertness have been recognised for many centuries. These
properties have been targeted by shiftworkers, long-haul
truck drivers, members of the military forces, athletes, and
other populations who need to fight fatigue or prolong their
capacity to undertake their occupational activities. Indeed,
the availability, in many countries, of nonprescription medi-
cations, energy drinks, confectionary and sports foods, and
(or) supplements that contain caffeine or guarana (Table 1)
has increased the opportunities for people to specifically
consume caffeine as an ergogenic (work-enhancing) aid.
The past 30 years has seen the publication of a substantial
Received 26 July 2008. Accepted 14 October 2008. Published on
the NRC Research Press Web site at on
6 December 2008.
L.M. Burke. Department of Sports Nutrition, Australian
Institute of Sport, P.O. Box 176, Belconnen, ACT, Canberra
2616, Australia (e-mail:
Appl. Physiol. Nutr. Metab. 33: 1319–1334 (2008) doi:10.1139/H08-130 #2008 NRC Canada
number of studies of caffeine supplementation and exercise
or physical activity. Table 2 provides a summary of our cur-
rent knowledge about the effects of caffeine on exercise ca-
pacity or performance from this robust literature. It is
beyond the scope of this paper to examine the mechanisms
by which caffeine exerts its ergogenic effects related to ex-
ercise on the body; readers are referred to several extensive
reviews for this information (Graham 2001a, 2001b, 2008;
Jones 2008; Keisler and Armsey 2006; Tarnopolsky 2008).
Instead, the aim of this paper is to discuss the available in-
formation on caffeine and exercise from the perspective of
sports performance. It should be noted that the views ex-
pressed in this paper only apply to adult athletes who
already consume caffeine within their normal dietary practi-
ces. This author believes it is inappropriate and unnecessary
for children and young adults to consume caffeine as an er-
gogenic aid, and notes that younger populations have the po-
tential for greater performance enhancement through
maturation and experience in their sport. Caffeine use in all
populations should be seen against the background of its ef-
fects on human health, where it has been suggested that, in
healthy adult populations, moderate daily caffeine intakes of
up to 400 mgd–1 or ~6 mgkg–1 are not associated with ad-
verse effects, whereas children aged 12 or under should
Table 1. Caffeine content of common foods, drinks, and nonprescription preparations.
Food or drink Serving Caffeine, mg*
Instant coffee 250 mL (8 oz) cup 60.(12–169){
Brewed coffee 250 mL (8 oz) cup 80.(40–110){
Short black coffee or espresso 1 standard serving 107.(25–214){
Starbucks Breakfast Blend brewed coffee (Venti size) 600 mL (20 oz) 415.(300–564)§
Iced coffee (commercial brands) 500 mL bottle (16 oz) 30.–200
Frappuccino 375 mL (12 oz) cup 90.
Tea 250 mL (8 oz) cup 27.(9–51){
Iced tea 600 mL (20 oz) bottle 20.–40
Hot chocolate 250 mL (8 oz) cup 5.–10
Chocolate milk 60 g 5.–15
Dark chocolate 60 g 10.–50
Viking chocolate bar 60 g 58.
Coca-Cola 375 mL (12 oz) can 49.
Pepsi cola 1375 mL (12 oz) can 40.
Jolt soft drink 1375 mL (12 oz) can 75.
Red Bull energy drink 250 mL (8 oz) can 80.
Red Eye Power energy drink 250 mL (8 oz) can 50.
V Energy drink 250 mL (8 oz) can 50.
Smart Drink - Brain fuel 250 mL (8 oz) can 80.
Lift Plus energy drink 250 mL (8 oz) can 36.
Lipovitan energy drink 250 mL (8 oz) can 50.
Black Stallion energy drink 250 mL (8 oz) can 80.
AMP Energy tallboy 500 mL (16 oz) can 143.
Spike Shotgun energy drink 500 mL (16 oz) can 350.
Fixx energy drink 600 mL (20 oz) can 500.
Ammo energy shot 30 g (1 oz) 170.
Jolt endurance shot 60 g (2 oz) 150.
PowerBar caffeinated sports gel 40 g sachet 25.
PowerBar double caffeinated sports gel 40 g sachet 50.
GU caffeinated sport gel 32 g sachet 20.
Carboshotz caffeinated sports gel 50 g sachet 80.
PB Speed sports gel 35 g sachet 40.
PowerBar Acticaf Performance bar 65 g bar 50.
Jolt caffeinated gum 1 stick 33.
No-Doz (Australia) 1 tablet 100.
No-Doz (U.S.) 1 tablet 200.
Extra Etrength Excedrin 1 tablet 65.
*These values were gathered from a variety of sources, including manufacturers’ information and nutrition databases (Centre
for Science in the Public Interest (available at, and USDA National Nutrient Database
(available at Note that commercial brands may vary slightly from country to
{The caffeine content of tea and coffee varies widely, depending on the brand, the way the beverage is made, and the size of the
mug or cup.
{Commercial samples bought from a variety of outlets (Desbrow et al. 2007).
§Commercial samples bought from the same Starbucks outlet (McCusker et al. 2003).
1320 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
limit their caffeine intake to <2.5 mgkg–1d–1 because of
their increased risk of behavioural side effects (Nawrot et
al. 2003).
Special issues related to study design for
examining caffeine and sports performance
Research design reflects a number of scientific and practi-
cal concerns, including the primary question (hypothesis) of
interest, level of funding, the availability and limitations of
equipment and subjects, interest in examining the mecha-
nisms underpinning outcomes, approval from ethics panels,
and the requirements or expectations of participants in the
peer-review process. Given the range of potential uses for
any beneficial effects of caffeine on physical and occupa-
tional activities, and the diverse interests of scientists who
have undertaken studies of caffeine and exercise, we might
expect that a variety of research protocols have been under-
taken. While many studies may have been able to address
issues related to caffeine and exercise per se, not all were
well suited to address special issues of sports performance.
Table 3 summarizes some of the characteristics of the
methodologies used in many studies of caffeine supplemen-
tation and exercise, and contrasts these with the features of
real-life sport.
One of the key tenets of research is that the results really
only apply to the population and the situation that was in-
vestigated. Therefore, Table 3 provides a list of the charac-
teristics that should be included in studies specifically
designed to investigate the effect of caffeine on sports per-
formance. It is likely that there is a spectrum of athletes
who are interested in the outcomes of such research. The re-
wards for achieving success in elite-level sports are highly
visible and offer a clear incentive to search for strategies
that can enhance performance by even a small margin.
Theoretically, the potential for detecting small but worth-
while changes in performance should be greater among elite
athletes. After all, elite athletes are usually highly reliable at
performing the tasks for which they have trained; a small
coefficient of variation in performance increases the preci-
sion of the separation of the true effects of an intervention
(the signal) from everyday differences in performance (the
Ironically, few studies on caffeine and elite athletes are
available. This is understandable because, by definition,
they are few and special. It is usually difficult to achieve a
large sample size of elite athletes for statistical rigour or to
impose the conditions or invasive techniques of research on
their training and competition schedules. Therefore, most
studies of caffeine and sports performance have been under-
taken on athletes at recreational to highly trained but sub-
elite levels (Tables 4–7). It is unclear whether the results of
Table 2. A summary of our current understanding of the effect of caffeine supplementation on exercise capacity or performance.
Issue Supporting evidence
There is sound evidence that caffeine enhances endurance and provides a small but
worthwhile enhancement of performance over a range of exercise protocols, with
the traditional protocol involving a caffeine dose of ~6 mgkg–1 body mass taken
1 h pre-exercise.
Jones (2008); Keisler and Armsey (2006); Doh-
erty and Smith (2004); Graham (2001a, 2001b)
Recent studies show that beneficial effects from caffeine occur at very modest levels
of intake (1–3 mgkg–1 body mass, or 70–150 mg caffeine).
Bridge and Jones (2006); Cox et al. (2002);
Kovacs et al. (1998); Graham and Spriet (1995)
Several studies suggest there is no dose–response relationship between caffeine
intake and benefits to endurance exercise or, if a dose–response exists, there is a
plateau at ~3 mgkg–1.
Anderson et al. (2000); Bruce et al. (2000); Cox
et al. (2002); Kovacs et al. (1998); Pasman et al.
(1995); Graham and Spriet (1995)
A variety of protocols of caffeine intake, including doses before or during exercise,
or after the onset of fatigue, may be beneficial for exercise capacity.
Cox et al. (2002); Kovacs et al. (1998)
Some tissues become tolerant to repeated caffeine use, while others do not. Since the
mechanisms by which caffeine exerts effects on performance are not fully known,
it is unclear whether an athlete should withdraw from caffeine prior to competition.
Some studies show that there is no difference in the performance response between
nonusers and users of caffeine. Withdrawal can be achieved by 24–48 h of
cessation of caffeine use. However, athletes should be aware of the side effects of
withdrawal, such as headaches, and the greater potential for negative side effects
from subsequent caffeine exposure.
Graham (2001b)
The effects of caffeine can be long lasting. Although there is some evidence that the
benefits do not persist up to 6 h, people who ingest caffeine to enhance a morning
exercise task may still receive benefits during a session undertaken later in the day.
Bell and McLellan (2002, 2003)
Coffee may not be a good source of caffeine for exercise enhancement; it is difficult
to know the dose of caffeine in any serving of coffee. Some studies have found
that while caffeine alone was ergogenic for a given exercise task, caffeine
consumed in a caffeine medium did not enhance performance of the same protocol.
Coffee may contain other ingredients that counteract the benefits of caffeine.
Nevertheless it appears that caffeine is ergogenic when coffee is consumed with a
prerace meal.
Graham et al. (1998); Graham (2001a, 2001b)
There is individual variability in the changes in exercise capacity in response to
caffeine. Some people are nonresponders to caffeine.
Graham and Spriet (1995)
Higher doses of caffeine (>6–9 mgkg–1) may be associated with side effects, such as
jitters, increased heart rate, and performance impairment.
Graham and Spriet (1995)
Burke 1321
#2008 NRC Canada
current research apply to the true elite, since top competitors
may have unusual characteristics, as a result of genetics or
conditioning, that have made them the best. However, we
can be sure that the population base to which the results of
currently available studies of caffeine and exercise and (or)
sport best apply is far larger than the elite athlete popula-
tion. It should also be remembered that athletes at lower lev-
els of competition can also be highly motivated, even if the
rewards are simply the satisfaction of achieving personal
bests. As such, they will be highly interested in utilizing the
results of caffeine studies. Although it would be good to see
more studies of elite athletes, the practicalities that prevent
this will mean that top class athletes will need to extrapolate
the information on protocols for caffeine in sport from stud-
ies of well-trained athletes, and to test what works for their
individual situation.
Sports scientists who work with athletes are understand-
ably interested in investigations that have been carried out
in a field setting or in a situation of sport (Berglund and
Hemmingsson 1982; Cohen et al. 1996; Van Nieuwenhoven
et al. 2005). The advantages of such studies relate to the val-
idity of performance measures, since they can include fea-
tures such as real airflow and ground resistance, real-life
pacing strategies (which are often stochastic), changes in
the environment and course over the event, and the effect
of competition and other extrinsic motivating factors. The
negatives of field and real-life settings typically include a
reduction in the control that is possible over the environ-
ment and the athlete. This is likely to reduce the precision
of the results and, therefore, the likelihood of detecting
small changes that could be important.
Therefore, it is important to recognise that our interest in
caffeine exists because of the laboratory-based studies in
which tight control has allowed the effects on metabolism
and exercise capacity or performance to be detected. As
well as selecting an appropriate subject pool, there are fea-
tures that can be built into laboratory (or field) studies to en-
hance the reliability and validity of the results in relation to
sporting activities. Table 3 lists many such factors, including
the choice of performance tasks that are related to sport, the
control or standardization of training and diet leading into
performance trials, and the choice of conditions that mimic
what happens in the world of sport. For example, some re-
cent studies of caffeine and endurance sports that have re-
quired subjects to be well fuelled from the days and the
meal leading into a performance trial, and have provided
carbohydrate intake during prolonged events are helpful
(Cox et al. 2002). Similarly, studies examining the inter-
action of caffeine with other proven ergogenic aids, such as
creatine (Doherty and Smith 2004) and bicarbonate
(Pruscino et al. 2008), are important, since this is a likely
scenario in real life.
The analysis and interpretation of the results of studies
need to be undertaken with sympathy for effect sizes that
would be worthwhile to an athlete. In many sports, the mar-
gins between winning and losing can be measured to several
decimal points. An emerging area in sports science is the
use of magnitude-based statistics, which look at the range
of the likely true effect of an intervention in comparison to
the differences in performance that might change the out-
come of an event (Batterham and Hopkins 2006). In fact,
Table 3. The characteristics of traditional laboratory-based research vs. research focussed on elite sports performance.
Characteristics of traditional studies Characteristics of elite and serious sport Comments on the ideal characteristics of studies on sports performance
Subjects are often drawn from available populations,
such as college students or recreationally and
moderately trained subjects.
Competitors are highly trained in their sport and event. Characteristics
include reliability in repeating a given performance task, and
specific adaptations achieved though natural selection of sport and
the conditioning effects of training.
Subjects should reflect the population to which the results of the study
are intended to apply; subjects should be familiar with and reliable in
undertaking the performance protocol; and studies that involve elite
or highly trained athletes are underrepresented and should be
Exercise protocols typically measure endurance or
exercise capacity (the ability to sustain a given
exercise task for as long as possible). The task is
terminated when the subject is fatigued and unable to
continue at the prescribed output.
Sports performance typically includes completing a task in the fastest
possible time (pace judgement is important), executing skills and
making complex decisions while undertaking exercise, and
executing a single task as well as possible. Training situations may
better represent the execution of an exercise task to fatigue.
Protocols should involve a close-looped task (i.e., completing a task in
the fastest time possible), which involves pacing rather than simply
exercising to fatigue; protocols should simulate, as much as possible,
a real-life event; and field studies are underrepresented and should be
Protocols are often undertaken with baseline metabolic
conditions (subjects fast overnight and consume only
water during exercise) and without the confounding
effects of other nutritional strategies.
Athletes undertake other nutrition strategies that provide additional
support for performance, including eating a carbohydrate-rich pre-
event meal consuming carbohydrates during prolonged events, and
using other scientifically supported ergogenic aids (e.g., bicarbonate,
Protocols should allow subjects to follow nutrition strategies that
optimize performance and reflect the real-life practices of athletes;
and studies should investigate the interaction between caffeine intake
and other nutrition strategies or supplements, and their combined
effect on performance.
Differences (which must reach a level of >5%
probability to be considered significant) in
performance between the control treatment and the
active treatments(s) are assessed using probability
The margins between winning and losing, or between the ‘‘podium’
athletes (first-, second-, and third-place winners) and the rest of the
field, can often be measured in hundredths of seconds and meters.
Differences in performance should be assessed using magnitude-based
statistics: the likely range of the true difference in performance
should be compared with the coefficient of variation of performance
for individuals undertaking that protocol.
Protocols are conducted with consideration to the
concerns of the ethics committee overseeing the
Sports are conducted within the regulations of their governing body,
and many athletes compete within an anti-doping code that may not
permit the use of otherwise legal products or strategies.
Projects that are focussed on high-level sports should be conducted
within the logistical and anti-doping rules that govern athletes in that
1322 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
Table 4. Crossover-designed studies of caffeine supplementation related to an endurance sport (>60 min).
Publication Subjects Caffeine intake Sports performance
performance Comments
Jenkins et al. (2008) Trained cyclists
(13 males)
(60 min pre-exercise)
15 min cycling (60%
) + 15 min TT
Yes for 2 and
doses; no for
1mgkg–1 dose
Work done during the 15 min TT was
increased by 4% (1–6.8) with 2 mgkg–1
of caffeine and by 3% (–0.4%–6.8%)
with 3 mgkg–1; improvement varied in
magnitude between individual cyclists
Cureton et al.
Well-trained cyclists
(16 males)
Total, 5.3 mgkg–1; 1.2 mgkg–1
pre-exercise + 0.6 mgkg–1 every
15 min during exercise
120 min cycling (60%
and 75% VO2max
15 min TT; CHO-fed
during cycling
Yes Higher exercise intensity in 15 min TT
with caffeine and CHO (90±11%
) vs. CHO alone (79±14 VO2max
Conway et al.
Trained cyclists and
triathletes (9 males)
6mgkg–1 60 min pre-exercise;
3mgkg–1 pre-exercise; and
3mgkg–1 at 45 min during
90 min cycling at 68%
VO2max + TT (~30 min)
Perhaps Trend to better performance in TT with
caffeine trials (~24.2 and 23.4 min) vs.
placebo (28.3 min) (p= 0.08); urinary
caffeine concentrations lower with split
Hunter et al. (2002) Highly trained
cyclists (8 males)
6mgkg–1 60 min before exercise +
0.33 mgkg–1 every 15 min
100 km cycling TT,
including 5 1 km and
44 km high-intensity
efforts; CHO-fed during
No No difference between trials with respect to
total 100 km time or time to complete
high-intensity efforts; no difference
between trials in EMG characteristics,
although differences within trial
attributable to workload
Cox et al. (2002) Well-trained cyclists
and triathletes
(12 males)
6mgkg–1 60 min pre-exercise; 6
1 mg every 20 min during
exercise; 10 mLkg–1 Coca-Cola
in last 50 min (~1–1.5 mgkg–1
2 h cycling at 70%
VO2max +7kJkg–1 TT
(~30 min); CHO-fed
during cycling
Yes at all doses Compared with placebo, caffeine in large
dose (6 mgkg–1) provided 3%
performance benefit in TT, regardless of
timing of intake; commercial cola drink
consumed late in exercise (~1 mgkg–1
caffeine) produced effects of equal
magnitude; urinary caffeine levels
~4–5 mgmL–1 for large dose of caffeine
and <1 mgmL–1 for cola drink
Cox et al. (2002) Well-trained cyclists
and triathletes
(8 males)
Sports drink replaced during last
70 min with 15 mLkg–1 of a cola
drink (caffeine dose ~1.5 mgkg–1):
6% CHO; 11% CHO; 6% CHO +
130 mgmL–1 caffeine; or 11%
CHO + 130 mgmL–1 caffeine*
2 h cycling at 70%
VO2max +7kJkg–1 TT
(~30 min); CHO-fed
during cycling
Yes Commercial cola drink consumed late in
exercise produced 3% performance
benefit in TT compared with cola-
flavoured placebo drink. Benefits
attributable to caffeine content (~2%) and
increased CHO intake (~1%)
Jacobson et al.
Trained cyclists
(8 males)
6mgkg–1 (60 min pre-exercise) 2 h cycling at 70%
VO2max +7kJkg–1 TT
(~30 min); CHO-fed
during cycling
No TT performance similar in caffeine + CHO
trial (29.12 min) and CHO trial
(30.12 min), with both trials better than
placebo trial
Ivy et al. (1979) Trained cyclists
(9 males + females)
Total dose, 500 mg; 250 mg at
60 min pre-exercise + 7 doses
during exercise
2 h isokinetic cycling at
80 rmin–1
Yes 7% increase in total work, compared with
placebo trial; RPE same, despite
increased work
Burke 1323
#2008 NRC Canada
Table 4 (concluded).
Publication Subjects Caffeine intake Sports performance
performance Comments
Kovacs et al. (1998) Well-trained cyclists
(15 males)
2.1 mgkg–1, 3.2 mgkg–1, and
4.5 mgkg–1 doses; 75 min
pre-exercise and at 20 and 40 min
during TT
Cycling TT of about
~1 h; CHO-fed during
Yes at all doses Addition of caffeine to CHO–electrolyte
drinks improved 60 min TT performance;
improvement with 3.2 and 4.5 mgkg–1
caffeine doses equal to and greater than
improvement with 2.1 mgkg–1; urinary
caffeine levels related to total dose, but
all below 12 mgmL–1
Cross-country Skiing
Berglund and
Well-trained cross-
country skiers
(14 males)
6mgkg–1 (prerace) 21 km cross-country ski
race (field study) at low
and high altitudes
Perhaps at low
altitude; yes at
high altitude
Race times were normalized to account for
differences in weather (individual times
expressed as % of mean race time); at
low altitudes, at half way, the race time
with caffeine was decreased by 0.9% of
the mean time (~33 s), compared with
placebo (p< 0.05); at full distance,
decrease was 1.7% of the mean time
(~59 s) (p< 0.1); at high altitudes, the
race time was significantly faster with
caffeine than with placebo (p< 0.001)
both after 1 lap (2.2% or ~101 s) and 2
laps (3.2% or ~152 s)
Distance running
Cohen et al. (1996) Trained runners
(5 males + 2
5mgkg–1,9mgkg–1 (prerace) 21 km half-marathon
(field study)
No No effects on RPE or performance at either
dose, compared with placebo
Van Nieuwenhoven
et al. (2005)
Trained to well-
trained runners
(90 males + 8
~1.3 mgkg–1 in 7% CHO sport
drink vs. CHO sport drink alone +
water (pre-exercise and at 4.5, 9,
and 13.5 km during race)
18 km road running race
(field study); CHO-fed
during some trials
No No differences in performance of whole
group between caffeinated sport drink
(78:03±8:42 min:s), sport drink
(78:23±8:47 min:s), or water (78:03±8:30
min:s), or for 10 fastest runners (63:41,
63:54, and 63:50 min:s for caffeine sport
drink, sport drink, and water,
Note: CHO, carbohydrate; EMG, electromyographical; RPE, rate of perceived exertion; TT, time trials; VO2 max, maximal oxygen consumption.
*Caffeine content equivalent to Coca-Cola.
1324 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
Table 5. Crossover-designed studies of caffeine supplementation and performance of sustained high-intensity sports (1–60 min).
Publication Subjects Caffeine intake Sports performance
performance Comments
Middle distance and distance running
Bridge and Jones
Distance runners
(8 males)
3mgkg–1 (60 min pre-exercise) 8 km race on track Yes Relative to the mean time of the control and
placebo trials, caffeine supplementation
resulted in a 23.8 s or 1.2% improvement in
run time (p< 0.05), with individual
improvements ranging from 10 to 61 s; heart
rate was significantly higher in caffeine trial,
with trend toward lower RPE, despite faster
running speed
Wiles et al. (1992) Well-trained runners
(18 males)
3 g of coffee (150–200 mg of
caffeine) 60 min pre-exercise
1500 m race on treadmill Yes Mean time improved by ~4.2 s (p< 0.05) with
caffeine, compared with placebo
Wiles et al. (1992) Well-trained runners
(10 males)
3 g of coffee (150–200 mg
caffeine) 60 min pre-exercise
1500 m race: 1100 m at
constant speed and 1 min
final burst at self-selected
Yes Caffeine enhanced speed of 1 min final burst by
~0.6 kmh–1, equivalent to 10 m (p< 0.05)
Bruce et al. (2000) Well-trained rowers
(8 males)
6mgkg–1 or 9 gkg–1 60 min
2000 m ergometer row Yes for both
Caffeine enhanced performance by a mean of
1.3% and 1% for 6 mgkg–1 and 9 gkg–1
doses, respectively, compared with placebo
(p< 0.05); some participants had urinary
caffeine concentrations >12 ngmL–1 with
higher caffeine dose, but participants were
unable to identify caffeine trials, suggesting
that effect is subtle
Anderson et al.
Well-trained rowers
(8 females)
6mgkg–1 or 9 gkg–1 60 min
2000 m ergometer row Yes for both
Caffeine enhanced performance by a mean of
0.7% and 1.3% for 6 mgkg–1 and 9 gkg–1
doses, respectively, compared with placebo
(p< 0.05); performance improvement achieve
primarily by enhancing the first 500 m
Burke et al.
(unpublished ob-
Elite and highly
trained swimmers
(15 males +
2mgkg–1 60 min prerace 100 m race (best stroke) No, but
lower RPE
No difference in reaction time, 50 m split, or
100 m race time between trials, but ratings of
perceived exertion was lower in the caffeine
trial (16.6 vs. 17.1; p= 0.01); self-reports of
sleeping patterns following the trial found that
caffeine supplementation was associated with
an increase in time taken to fall asleep and a
reduction in quality of sleep
MacIntosh and
Wright (1995)
(11 males +
6mgkg–1 60 min prerace 1500 m freestyle race Yes 23 s improvement in swimming time with
caffeine (p< 0.05); caffeine affected substrate
and electrolyte balance
Burke 1325
#2008 NRC Canada
these performance differences are not the hundredths of sec-
onds or millimetres that often separate competitors or a win-
ning shot from a miss in the memorable moments of sport.
Rather, the modelling of athletic performances has shown
that they are related to the coefficient of variation of per-
formers in the event (Hopkins et al. 1999). Readers are di-
rected to the work of Will Hopkins and colleagues, which
describes this new approach (Batterham and Hopkins 2006;
Hopkins et al. 1999) and provides resources with which to
undertake it (
It is sometimes difficult to convince the reviewers of jour-
nals to accept this new approach, and some researchers try
to combine traditional probability-based statistics with a
more athlete-friendly interpretation. For example, Wiles and
colleagues (2006) undertook a laboratory-based study simu-
lating the 1 km cycling time trial in track cycling. They
found that caffeine supplementation enhanced the perform-
ance of trained cyclists by a mean of 2.4 s, or 3.1%, which
achieved statistical significance. However, in highlighting
the relevance of these results, they noted that the 95% con-
fidence limits of this effect (the range of likely true effects
in a similar cycling population) showed a decrease in 1 km
time, ranging from 0.7% to 5.6%. To put this into context,
at the mens 1 km event at the 2004 Summer Olympic
Games in Athens, the difference between the gold and silver
medal performances was 0.0185 s, or 0.3%, while the differ-
ence between first and tenth place was 2.39 s (Wiles et al.
Finally, the issue of the blinding of caffeine supplementa-
tion is important to consider. A double-blinded application
of an intervention, in which neither the subject nor the re-
searcher know which treatment has been received, is consid-
ered a benchmark of study design. However, because
caffeine has effects on various body functions, subjects are
sometimes able to detect whether or not they have received
an active treatment from clues such as changes in heart rate
or arousal. The placebo effect has been well documented in
sport. In fact, studies in which trained subjects were told
that they were receiving caffeine showed a dose-dependent
improvement in cycling time-trial performance (small im-
provement when they thought they were receiving a small
caffeine dose, and larger improvement when they thought
they were receiving a large caffeine dose), even when they
actually received an inert substance on all occasions (Beedie
et al. 2006). Since the perceived benefit of a treatment may
actually allow subjects to perform better, researchers should
consider strategies to minimize or at least recognise the pos-
sibility that the placebo effect occurs in response to the un-
masking of a blinded treatment. Asking subjects to rank the
order of their treatments and their performance results may
uncover whether the placebo effect could be, at least in
part, responsible for performance outcomes.
Studies of caffeine and sports performance
So what does the current scientific literature say about the
effect of caffeine on sports performance? A summary has
been prepared that includes studies that meet as many of
the criteria outlined in Table 3 as possible, but with particu-
lar focus on the use of trained subjects, and an exercise pro-
tocol involving a close-looped outcome rather than time to
Table 5 (concluded).
Publication Subjects Caffeine intake Sports performance
performance Comments
Collomp et al.
Trained swimmers
(14 males +
250 mg (~4 mgkg–1) 60 min
2100 m swimming races,
separated by 20 min
Yes Caffeine enhanced mean swimming velocity in
both 100 m races (p< 0.01), and prevented the
decrease in velocity otherwise seen in the
second swim with the placebo treatment
Track cycling
Wiles et al. (2006) 8 trained cyclists 5 mgkg–1 75 min pre-exercise 1 km cycling TT Yes Performance improved by a mean of 2.4 s or
3.1% (95% CI, 0.7% to 5.6%; p< 0.05),
which also achieved practical significance in
context of real-life 1 km track cycling event
1326 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
Table 6. Crossover-designed studies of caffeine supplementation and stop-and-go sports (team and racquet sports).
Publication Subjects Caffeine intake Sports performance
performance Comments
Team sports
Stuart et al. (2005) Rugby union players
(9 males)
(70 min pre-exercise)
240 min circuits
(simulated rugby union
protocol), involving
repetitions of:
Study involved probability statistics rather than
testing of null hypothesis. Interpretation
included change in fatigue with caffeine,
compared with placebo. Mean improvements of
0.5%–3% in performance of sprint tasks, with
greater improvement in second half. Suggests
caffeine effect achieved by reduction in fatigue.
Improvement (10%) in ability to pass ball
accurately because of enhancement of arousal
or attention.
20 m sprint speed Possible
30 m sprint speed Very likely
Offensive sprint Likely
Defensive sprint Likely
Drive 1 power Likely
Drive 2 power No, harm
Tackle speed Likely
Passing ability Likely
Schneiker et al. (2006) Team athletes
(10 males)
(60 min pre-exercise)
236 min cycle protocol,
each involving:
Total work during sprints in first half was 8.5%
greater in caffeine trial than placebo, and work
in second half was 7.6% greater in caffeine trial
(p< 0.05 for both). Mean peak power score
achieved during sprints in first and second
halves were 7% and 6.6% greater, respectively,
in caffeine trial than in placebo trial (p< 0.05
for both).
18 4 s sprint with
2 min recovery
Paton et al. (2001) Team athletes
(16 males)
(60 min pre-exercise)
10 20 m sprints on
interval of 10 s
No Negligible difference between caffeine and
placebo trials for time to complete 10 sprints
and decay in performance over 10 sprints.
Racquet sports
Strecker et al. (2007) Collegiate tennis
players (10 males)
(90 min pre-exercise)
Skill test performed pre-
exercise, 30 min, 60 min,
and 90 min during
simulated tennis play
against a ball machine (15
ground strokes in all 4
directions; 60 shots total):
Caffeine trial showed better performance of both
forehand shots across the 90 min of simulated
tennis play. There was no difference in skill in
backhand shots between trials.
Forehand cross-court Yes
Forehand up the line Yes
Backhand cross-court No
Backhand up the line No
Burke 1327
#2008 NRC Canada
fatigue. There are relatively few investigations that meet
these criteria in the larger literature on caffeine and exercise
(Doherty and Smith 2004); these have been grouped accord-
ing to the characteristics of endurance (Table 4), sustained
high-intensity (Table 5), stop-and-go (Table 6), and strength
and (or) power (Table 7) sports.
The majority of the studies of caffeine and athletic per-
formance concern endurance sports, including running, cy-
cling, and cross-country skiing events. These provide
reasonable but not unanimous support that caffeine use can
be beneficial for these activities. A variety of protocols ap-
pear to be useful, including intake before and during the
event, and investigations using relatively low doses of
caffeine (2–3 mgkg–1) have been more prevalent in these
sports. There is also evidence that caffeine can enhance
performance of sustained high-intensity events (lasting 1–
20 min) in running, cycling, swimming, and rowing. It is
more difficult to find clear support for benefits to the per-
formance of work patterns and skills activities within team
and racquet sports. Whether the effect of caffeine is smaller
or absent in these sports, or whether the current studies are
confounded by problems in the reliability or validity of pro-
tocols, requires further examination. Finally, there is a
dearth of studies involving strength or power, such as true
sprints, lifts, and throws; therefore, there is currently a lack
of information on the effect of caffeine on such events.
Other effects of caffeine related to sports
nutrition goals
The previous section examined the effects of specific sup-
plementation with caffeine on the performance of a single
bout of exercise, with the most immediate application being
the outcome of a competitive event. However, any summary
of the effects of caffeine for an athlete should be widened to
consider issues of training and recovery. It is beyond the
scope of this paper, and indeed the scientific literature, to
consider the effect of caffeine on repeated bouts of exercise
within a single session or from day to day (i.e., the training
scenario). Nevertheless, it is reasonable to speculate that the
habitual social intake of caffeine, or its specific use in rela-
tion to a training session, may have some benefits in
promoting endurance — that is, prolonging the athlete’s ca-
pacity to undertake the physical and mental components of
their workout. Therefore, caffeine use may indirectly en-
hance competition performance by allowing the athlete to
train hard.
There are several other effects of caffeine that may make
an indirect contribution to or may impair sports perform-
ance. First, the effect of caffeine on promoting wakefulness
or interfering with sleep must be considered in the practical
context of sport. In many sports, the outcome of a competi-
tion is decided through a series of races or games spread
over days — for example, heats and semi-finals before the
final event, or the schedule of matches in a tournament. In
studies of exercise in the military context, caffeine has been
shown to combat the effects of sleep deprivation on the per-
formance of mentally and physically challenging tasks.
However, there are no studies that satisfactorily consider
that caffeine use by athletes in competition could potentially
contribute to sleep deprivation after the first event and im-
Table 6 (concluded).
Publication Subjects Caffeine intake Sports performance
performance Comments
Vergauwen et al. (1998) Well-trained tennis
players (13 males)
1 h pre-exercise +
0.75 mgkg–1h–1 over
2 h; separate trials for
caffeine + CHO,
CHO only, and
Tests undertaken pre and
post 2 h match play:
CHO trial resulted in maintenance of stroke
quality and shuttle run speed, whereas placebo
trial resulted in deterioration of these aspects of
performance. Caffeine added to CHO did not
further enhance post-trial performance. Authors
suggest that caffeine dose was too high.
However, it is also possible that effect could
only be expected if protocol had caused fatigue,
and this did not occur because of CHO intake.
Skills test (Leuven
Tennis Performance
Test) measuring stroke
70 m shuttle run (CHO
consumed in some
Ferrauti et al. (1997) Competitive tennis
players (8 males + 8
364 mg for males,
260 mg for females
(~4–4.5 mgkg–1)
4 h singles tennis (with
30 min break after
150 min); tests of skill
and speed undertaken at
end of 4 h:
No effect of caffeine supplementation on tennis-
specific running speed; caffeine trial not
different than placebo trial. No effect on hitting
accuracy or success of games played during 4 h
with male participants. However, female
players had greater success during tennis play
on caffeine than on placebo.
615 min sprint with
30 min rest
Hitting accuracy and
success during games
males, no
1328 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
pair the performance of subsequent events. It would be val-
uable if future studies of caffeine and performance of an ex-
ercise task examined whether caffeine doses that are found
to be ergogenic also affect the quality and duration of sleep
during the night following the exercise task. More sophisti-
cated studies are needed to measure the carryover effect of
caffeine-related impairment of sleep on subsequent perform-
ance. This would be an important issue to study because
there is at least anecdotal evidence that some athletes resort
to a cycle of caffeine supplementation followed by use of
sleeping agents during a multiday competition. Until such
studies can be undertaken, it would seem prudent for scien-
tists and athletes to look for the smallest dose of caffeine
that is ergogenic for sports performance.
Another indirect way in which caffeine supplementation
can affect sports performance is through its impact on hy-
dration status during exercise or in the recovery between ex-
ercise bouts. Acute intake of caffeine is known to have a
diuretic effect — that is, to increase urine excretion. Indeed,
common education messages regarding caffeine include ad-
vice to limit caffeine intake in situations in which hydration
is challenged (e.g., air travel) or to consume extra fluid in
combination with the intake of caffeine. There are a few
studies involving exercise and hydration that show that caf-
feine can have a numeric effect on fluid losses. For exam-
ple, during recovery from exercise, the intake of caffeine
from cola beverages has been shown to cause a small but
statistically significant increase in urine production, com-
pared with hydration with caffeine-free fluids (Gonzalez-
Alonso et al. 1992). However, a recent review of caffeine
and hydration status found that there is little scientific evi-
dence that caffeine intake impairs overall fluid status
(Armstrong 2002). That report concluded that the effect of
caffeine on diuresis is overstated and may be minimal in
people who are habitual caffeine users. In fact, many studies
that have examined caffeine supplementation and fluid bal-
ance have found that doses of caffeine that are within the
range proven to be ergogenic do not alter sweat rates, urine
losses, or indices of hydration status during exercise
(Millard-Stafford et al. 2007; Wemple et al. 1997). Chronic
daily intakes of caffeine, or a sudden increase in caffeine in-
take, have also been shown not to impair body fluid balance
(Armstrong et al. 2005; Fiala et al. 2004). Therefore, it
seems that athletes do not need to alter their fluid intake
strategies to accommodate caffeine use or to avoid otherwise
successful caffeine supplementation strategies in hot weather
or other dehydrating environments.
Finally, caffeine is known to have a range of apparently
contradictory effects on carbohydrate metabolism, including
short-term impairment of insulin-mediated glucose disposal
in response to an acute dose at rest, along with an ap-
parently protective effect (at least for coffee consumption)
on the development of type II diabetes (for review, see van
Dam and Hu 2005). One outcome of an effect of caffeine on
glucose disposal would be to impair the synthesis of muscle
glycogen, a key element of recovery after prolonged or
high-intensity exercise. However, Battram and colleagues
(2004) found that the intake of 6 mgkg–1 of caffeine before
and during glycogen-depleting exercise did not affect the
rate of glycogen synthesis during the 5 h of recovery when
adequate amounts of carbohydrate were consumed. There
has been recent attention directed to the results of a study
reporting enhanced muscle glycogen resynthesis following
glycogen-depleting exercise in well-trained subjects. In that
study, the intake of large amounts of caffeine after exercise
(8 mgkg–1) were found to enhance the rates of muscle gly-
cogen synthesis over 4 h of recovery, by 66%, when co-
ingested with carbohydrate (Pedersen et al. 2008). In fact,
the rates of sustained postexercise glycogen synthesis over
this time period were among the highest reported in the lit-
erature. However, the intake of such high doses of caffeine
may cause side effects in some subjects or may interfere
with other aspects of recovery, such as the quality of sleep
(see earlier). As such, they may be impractical for use in
sport. Further studies are needed to examine whether this ef-
fect is seen at lower levels of caffeine intake.
The politics of caffeine in sport
The 1984 Summer Olympic Games in Los Angeles saw
the introduction of an anti-doping program by the Interna-
tional Olympic Committee, involving the testing of a single
urine sample collected after an event for the absence or
presence of items described on a list of prohibited substan-
ces. Caffeine was included on that list, with the definition
of a doping offence being a urinary caffeine exceeding a
cutoff of 15 mgmL–1. This threshold was reduced in 1985
to 12 mgmL–1. The cutoff value was chosen to exclude nor-
Table 7. Studies of caffeine supplementation and performance of power events (throws, lifts, sprints <20 s).
Publication Subjects Caffeine intake Sports performance
performance Comments
Astorino et al.
22 resistance-
trained males
(60 min pre-
1 RM bench press No No changes in strength of lower or
upper body with caffeine
1 RM leg press No
Beck et al.
37 resistance-
trained males;
design (trials
48 h apart)
(60 min pre-
1 RM bench press Yes Caffeine supplement group showed
a 2% (2 kg) increase in upper
body strength (1 RM bench press)
following treatment, but no
change in placebo group; there
were no differences in lower body
strength in either group
1 RM leg extension No
Note: RM, repetition maximum.
Burke 1329
#2008 NRC Canada
mal or social coffee drinking (Delbeke and Debackere 1984)
and to target the doses of caffeine that were being found to
be ergogenic in the studies of the time. Indeed, with caffeine
supplementation of up to 5–6 mgkg–1, positive urinary caf-
feine levels are unlikely (Conway et al. 2003; Cox et al.
2002; Kovacs et al. 1998; Pasman et al. 1995); a substantial
risk of urinary caffeine values greater than 12 mgmL–1 does
not occur until intakes are greater than 9 mgkg–1 (Pasman et
al. 1995). It is unclear whether this ban was primarily re-
lated to safety concerns over intakes of very large doses of
caffeine or the ethics of achieving performance advantages
through caffeine use. In any case, there were relatively few
cases of positive doping outcomes for caffeine use among
elite athletes over the subsequent decade.
In the new millennium, the landscape of caffeine in sport
has changed markedly. First, there is greater awareness of
the frailty of urinary caffeine concentrations as a marker of
caffeine use. Urinary concentration reflects the small amount
(~1%) of plasma caffeine that escapes metabolism and is ex-
creted unchanged. Metabolic clearance of caffeine varies
widely among athletes and among different occasions of use
by the same athlete (Birkett and Miners 1991). Urinary caf-
feine levels are determined by a variety of factors, including
the size of caffeine dose, the metabolic clearance of caf-
feine, and the timing of the urine sample in relation to the
caffeine dose. Since there is huge variation in urinary caf-
feine content for the same caffeine dose, and neither the
standardization of the time between caffeine intake and
urine collection nor the prevention of opportunities to uri-
nate during or after an event, we now recognise that urinary
caffeine levels have no practical utility as markers of a par-
ticular use of caffeine.
Second, the emerging evidence from studies over the past
decade is that performance benefits can be found with very
modest caffeine intakes (e.g., 2–3 mgkg–1 body mass, or
~100–200 mg caffeine) when caffeine is taken before and
(or) during exercise. Furthermore, there is no evidence of a
dose–response relationship to caffeine beyond this level of
intake — that is, performance benefits do not increase with
increases in the caffeine dose. One of the practical outcomes
of these newer findings is that athletes no longer need to
practise controlled doping (i.e., finding the largest dose of
caffeine that can be taken while keeping urinary caffeine
levels below 12 mgmL–1). Instead, performance benefits can
be found with caffeine intakes that are well within, or even
below, normal social uses. Such intakes of caffeine are
likely to be associated with very low urinary caffeine levels
in most athletes. In essence, there is no longer a distinction
between normal (social) caffeine intake and caffeine intake
that enhances performance.
Finally, there have been changes in the methods and in-
tentions of the major anti-doping programs. The World
Anti-Doping Agency (WADA) was created in 1999 as an in-
dependent international organization that promotes, coordi-
nates, and monitors the fight against doping in sport in all
its forms ( Following
work to harmonise anti-doping policies and rules among
sports and authorities, it took over the anti-doping work of
the International Olympic Committee and instituted its first
code and international standards on 1 January 2004. The
WADA Code is still based on a List of Prohibited Substan-
ces and Methods (see
ch2? However, the code has evolved
to include the possibility of ‘‘nonanalytical violations.’’ Ath-
letes (and their support staff) can be found guilty of a dop-
ing offence without a positive urine or blood test. Other
offences include the possession or admitted use of these pro-
hibited substances or methods.
The code that immediately preceded the institution of
the first WADA Code, the 2003 Olympic Movement Anti-
Doping Code, included caffeine within the category of
stimulants banned in competition, with an explanatory com-
ment that ‘‘for caffeine the definition of a positive is a con-
centration in urine greater than 12 mg/mL.’’ (International
Olympic Committee 2003) However, there are several inter-
pretations of the wording of this code. It could mean that
caffeine is a prohibited substance with the collary. Further-
more, it could mean that a urinary caffeine concentration >
12 mgmL–1 could serve as a reporting limit, and that all ob-
served or admitted uses of caffeine would constitute a
doping offence. Alternatively, it could mean that caffeine is
permitted at doses that produce urinary caffeine concentra-
tions < 12 mgmL–1. These interpretations have widely dif-
ferent and far-reaching outcomes. Indeed, there are a range
of different issues related to the different positions that caf-
feine could have in an anti-doping code, many of which
would create considerable practical challenges if imple-
mented (Table 8).
In fact, caffeine was removed from WADA’s List of Pro-
hibited Substances and Methods that came into effect on
1 January 2004, meaning that athletes could consume
caffeine, either in their background diets or for the specific
purposes of performance enhancement, without fear of
sanctions. However, it is currently still on the list of banned
drug classes of the National Collegiate Athletic Association,
the body governing college sport in the United States (http://
drug_testing/banned_drug_classes.pdf). Furthermore, caffeine
is part of the WADA monitoring program, meaning that caf-
feine concentrations are still measured in urine samples as a
means of detecting patterns of misuse in sport. This has al-
lowed some examination of the impact of the removal of caf-
feine from the prohibited list on caffeine use patterns by
athletes. Some recent studies have found a high prevalence of
caffeine use for perceived ergogenic effects among select
groups of athletes, such as Ironman triathletes (Desbrow and
Leveritt 2006) and British track and field athletes and cyclists
(Chester and Wojek 2008). However, measurement of over
4600 urine samples undertaken for doping control across
56 sports by a single laboratory in 2004 found no increase
in the mean caffeine concentration, compared with results
from 1993–2002 (Van Thuyne and Delbeke 2006). The
mean caffeine concentration in samples in 2004 was
1.12 mgmL–1, in comparison to a finding of 1.22 mgmL–1
from over 11 000 samples collected in 1993–2002 (Van
Thuyne et al. 2005). The 2004 study noted differences in
caffeine use among sports, with an increased average con-
centration and a larger percentage of higher urinary caf-
feine concentrations (defined as >4 mgmL–1) in cycling
and strength and (or) power sports than in other sports.
Cycling showed an apparent increase in the percentage of
higher urinary caffeine concentrations in 2004, while there
1330 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
Table 8. Examples of potential rulings regarding caffeine use in sport (Burke 2001).
Ruling Implications and issues
1. Caffeine is a prohibited substance in competition in absolute terms
Underpinning rationale: (i) caffeine
is a stimulant; (ii) caffeine intake
enhances sports performance;
(iii) caffeine is neither a nutrient
nor a necessary part of the diet.
Athletes would not be able to consume any tea, coffee, cola drinks, chocolate, etc., prior to and
during competition.
Strong education messages would be needed to convey this message and its implications to
The limit of urinary caffeine content would need to be set at very low levels. Although some
athletes would be able to consume caffeine and remain below this limit, a positive doping
offence would also be deemed to occur if the athlete was observed or admitted to consuming a
caffeine-containing product during the competition period.
Presumably, the difficulty in removing all caffeine from the normal diet would result in a large
number of positive doping offences.
Issues of possession and trafficking would need to consider the sale of tea, coffee, cola, and
chocolate at sporting venues, and the sponsorship of athletes, events, and sporting organizations
by companies that manufacture these products. These activities would need to be banned to be
consistent with the anti-doping code.
Even though caffeine intake would be banned in competition, athletes would still be able to
consume caffeine during training in a manner that provides a benefit to their performance and
adaptation to the training program.
2. Caffeine is a prohibited substance only when consumed in competition settings in doses that produce urinary caffeine levels
above a certain limit (to be determined)
Underpinning rationale: aurinary
caffeine limit can be set that
discriminates between social and
intentional use of caffeine, or at
least only picks up a few cases of
high caffeine use.
It is impossible to find a limit that distinguishes between social and intentional use of caffeine.
Caffeine intakes that produce a performance enhancement are indistinguishable from the
caffeine intakes reported by the normal population.
Urinary caffeine levels vary among and within individuals, and there is no standardization of the
collection of urine samples with regard to the timing between caffeine intake and sampling.
Therefore, urinary caffeine limits do not treat caffeine use equally.
Education messages to athletes could contain information about levels of caffeine intake that are
unlikely to produce a urinary caffeine level above this limit.
Athletes could not investigate their urinary caffeine concentrations in relation to various levels
of intake (trying to find how much caffeine they can take without producing a positive result for
caffeine doping), since this would be regarded as controlled doping.
Issues related to possession and trafficking of caffeine (as outlined in ruling 1) could still apply.
3. Caffeine is a prohibited substance only when intentionally consumed in competition settings in doses that produce urinary
caffeine levels above a certain limit (to be determined)
Underpinning rationale: a model
similar to drinking and driving
laws will prevent accidental cases
of high caffeine levels.
As in ruling 2, except that since urinary caffeine levels vary among individuals, and there is no
standardization of the collection of urine samples with regard to the timing between caffeine
intake and sampling, athletes should be allowed (or encouraged) to investigate what intakes of
caffeine can be tolerated without producing a positive test, without any penalty or prejudice. The
concept of controlled doping would not be applicable.
4. The prohibition on caffeine use in sport is removed
Underpinning factors: (i) caffeine is
so entrenched in the normal diet
that it is not practical to try to
achieve a ban on intake; (ii) there
is no unfair advantage if the
majority of athletes already
consume caffeine, and choose to
consume it for social reasons;
(iii) there are no health
disadvantages to the intake of
small amounts of caffeine; (iv) the
ergogenic benefits of caffeine on
performance, although worthwhile,
are small — they are similar in
magnitude to the effects of
consuming CHO during an
endurance event, but less than the
beneficial effects of consuming
fluid to minimize dehydration
Practical solution to overcome challenging situation.
Avoids tainting common foods and (or) drinks or common transactions in sport (e.g.,
sponsorship of companies that produce these products) with the odium of cheating.
Research should target the smallest dose of caffeine that can produce an ergogenic benefit.
Education messages to athletes could promote the message that, if they want to use caffeine
(socially or intentionally), small intakes produce maximal effects. Athletes would be encouraged
to reduce rather than increase their intake of caffeine, thus minimizing the health implications
and cost of using special products.
The market for specialized sports products containing caffeine might increase, unless education
messages (as above) remove the perceived benefits of large doses of caffeine or the need for
special food products.
Note: CHO, carbohydrate.
Burke 1331
#2008 NRC Canada
was a decrease in this outcome in swimming and basket-
ball. Overall, there was a decrease in the percentage of
urine samples showing caffeine concentrations below the
detectable range, and no increase in the percentage of sam-
ples with concentrations above 12 mgmL–1. In fact, only 6
samples were found with a concentration above the former
cutoff level (Van Thuyne and Delbeke 2006).
Further monitoring needs to take place before firm con-
clusions can be made. Nevertheless, it seems that there is lit-
tle evidence of systematic increases in the use or misuse of
caffeine at the highest levels of sport. One outcome of the
removal of caffeine from the prohibited list is the potential
for an increase in research activities and transparent educa-
tion about the benefits and disadvantages of caffeine use in
sport. Greater dissemination of the emerging information
that the benefits of caffeine occur at small to moderate
doses, and of the presence of individual variability and po-
tential side effects in response to caffeine intake, may ac-
tually lead to a reduction in caffeine use by athletes (e.g.,
lower doses being taken on fewer occasions). There is inad-
equate information about the total caffeine intakes of ath-
letes and recreational sportspeople and their patterns of
caffeine use. However, by choosing to withdraw caffeine in-
take before key events and by using the minimum ergogenic
doses during competition or training sessions, it is possible
that athletes will not consume more caffeine than the gen-
eral population, but rather, consume it in a more targeted
manner in relation to their sporting activities.
Caffeine is widely consumed from a variety of sources as
part of a normal diet, as well as in specialized sports foods
and supplements that may be used by athletes during train-
ing and competition. There is clear evidence that caffeine is
an ergogenic aid for a variety of types of sports, although
studies involving elite athletes and field situations are lack-
ing. Further research is needed to define the range of caf-
feine protocols and sports activities that show evidence of
performance enhancement, as well as the benefits or harm
to other issues underpinning recovery after exercise or prep-
aration for an event. Newer evidence suggests, at least in en-
durance sports, that the maximal benefits of caffeine are
seen at small to moderate caffeine doses (2–3 mgkg–1),
which are well within the normal daily caffeine intakes of
the general population. This makes the recent decision to re-
move caffeine from the list of prohibited substances in
sports a pragmatic choice. To date, there is little evidence
that this change has increased the use or misuse of caffeine
by athletes, at least within the levels of elite and subelite
sport, where anti-doping codes apply. Caffeine use may also
enhance the performance of sport in recreational athletes,
but it is inappropriate and unnecessary for use by young
adults. There is a need for strong and transparent education
to ensure that the correct messages about caffeine in sport
are provided to all athletes.
Anderson, M.E., Bruce, C.R., Fraser, S.F., Stepto, N.K., Klein, R.,
Hopkins, W.G., and Hawley, J.A. 2000. Improved 2000-meter
rowing performance in competitive oarswomen after caffeine in-
gestion. Int. J. Sport Nutr. Exerc. Metab. 10: 464–475.
Armstrong, L.E. 2002. Caffeine, body fluid-electrolyte balance,
and exercise performance. Int. J. Sport Nutr. Exerc. Metab. 12:
189–206. PMID:12187618.
Armstrong, L.E., Pumerantz, A.C., Roti, M.W., Judelson, D.A.,
Watson, G., Dias, J.C., et al. 2005. Fluid, electrolyte, and renal
indices of hydration during 11 days of controlled caffeine con-
sumption. Int. J. Sport Nutr. Exerc. Metab. 15: 252–265.
Astorino, T.A., Rohmann, R.L., and Firth, K. 2008. Effect of caffeine
ingestion on one-repetition maximum muscular strength. Eur. J.
Appl. Physiol. 102: 127–132. doi:10.1007/s00421-007-0557-x.
Batterham, A.M., and Hopkins, W.G. 2006. Making meaningful infer-
ences about magnitudes. Int. J. Sports Physiol. Perform. 1: 50–57.
Battram, D.S., Shearer, J., Robinson, D., and Graham, T.E. 2004.
Caffeine ingestion does not impede the resynthesis of proglycogen
and macroglycogen after prolonged exercise and carbohydrate
supplementation in humans. J. Appl. Physiol. 96: 943–950.
doi:10.1152/japplphysiol.00745.2003. PMID:14617526.
Beedie, C.J., Stuart, E.M., Coleman, D.A., and Foad, A.J. 2006.
Placebo effects of caffeine on cycling performance. Med. Sci.
Sports Exerc. 38: 2159–2164. doi:10.1249/01.mss.0000233805.
56315.a9. PMID:17146324.
Beck, T.W., Housh, T.J., Schmidt, R.J., Johnson, G.O., Housh,
D.J., Coburn, J.W.,et al. 2006. The acute effects of a caffeine-
containing supplement on strength, muscular endurance, and
anaerobic capabilities. J. Strength Cond. Res. 20: 506–510.
Bell, D.G., and McLellan, T.M. 2002. Exercise endurance 1, 3, and
6 h after caffeine ingestion in caffeine users and nonusers. J.
Appl. Physiol. 93: 1227–1234. PMID:12235019.
Bell, D.G., and McLellan, T.M. 2003. Effect of repeated caffeine
ingestion on repeated exhaustive exercise endurance. Med. Sci.
Sports Exerc. 35: 1348–1354. doi:10.1249/01.MSS.0000079071.
92647.F2. PMID:12900689.
Berglund, B., and Hemmingsson, P. 1982. Effects of caffeine in-
gestion on exercise performance at low and high altitudes in
cross-country skiers. Int. J. Sports Med. 3: 234–236. PMID:
Birkett, D.J., and Miners, J.O. 1991. Caffeine renal clearance and
urine caffeine concentrations during steady state dosing Implica-
tions for monitoring caffeine intake during sports events. Br. J.
Clin. Pharmacol. 31: 405–408. PMID:2049248.
Bridge, C.A., and Jones, M.A. 2006. The effect of caffeine ingestion
on 8 km run performance in a field setting. J. Sports Sci. 24:
433–439. doi:10.1080/02640410500231496. PMID:16492607.
Bruce, C.R., Anderson, M.E., Fraser, S.F., Stepto, N.K., Klein, R.,
Hopkins, W.G., and Hawley, J.A. 2000. Enhancement of 2000-m
rowing performance after caffeine ingestion. Med. Sci. Sports
Exerc. 32: 1958–1963. doi:10.1097/00005768-200011000-00021.
Burke, L.M. 2001. Report from workshop on caffeine in sport. De-
cember 2001. Australian Institute of Sport, Canberra, Australia.
Chester, N., and Wojek, N. 2008. Caffeine consumption amongst
British athletes following changes to the 2004 WADA prohib-
ited list. Int. J. Sports Med. 29: 524–528. doi:10.1055/s-2007-
989231. PMID:18027309.
Cohen, B.S., Nelson, A.G., Prevost, M.C., Thompson, G.D., Marx,
B.D., and Morris, G.S. 1996. Effects of caffeine ingestion on en-
durance racing in heat and humidity. Eur. J. Appl. Physiol. Occup.
Physiol. 73: 358–363. doi:10.1007/BF02425499. PMID:8781869.
Collomp, K., Ahmaidi, S., Chatard, J.C., Audran, M., and Prefaut,
1332 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
C. 1992. Benefits of caffeine ingestion on sprint performance in
trained and untrained swimmers. Eur. J. Appl. Physiol. Occup.
Physiol. 64: 377–380. doi:10.1007/BF00636227. PMID:1592065.
Conway, K.J., Orr, R., and Stannard, S.R. 2003. Effect of a divided
dose of endurance cycling performance, postexercise urinary
caffeine concentration and plasma paraxanthine. J. Appl. Phy-
siol. 94: 1557–1562. doi:10.1063/1.1589600. PMID:12482764.
Cox, G.R., Desbrow, B., Montgomery, P.G., Anderson, M.E.,
Bruce, C.R., Macrides, T.A., et al. 2002. Effect of different pro-
tocols of caffeine intake on metabolism and endurance perfor-
mance. J. Appl. Physiol. 93: 990–999. PMID:12183495.
Cureton, K.J., Warren, G.L., Millard-Stafford, M.L., Wingo, J.E.,
Trilk, J., and Buyckx, M. 2007. Caffeinated sports drink: ergo-
genic effects and possible mechanisms. Int. J. Sport Nutr. Exerc.
Metab. 17: 35–55. PMID:17460332.
Delbeke, F.T., and Debackere, M. 1984. Caffeine: use and abuse in
sports. Int. J. Sports Med. 5: 179–182. PMID:6480201.
Desbrow, B., and Leveritt, M. 2006. Awareness and use of caffeine
by athletes competing at the 2005 Ironman Triathlon World
Championships. Int. J. Sport Nutr. Exerc. Metab. 16: 545–558.
Desbrow, B., Hughes, R., Leveritt, M., and Scheelings, P. 2007. An
examination of consumer exposure to caffeine from retail coffee
outlets. Food Chem. Toxicol. 45: 1588–1592. doi:10.1016/j.fct.
2007.02.020. PMID:17412475.
Doherty, M., and Smith, P.M. 2004. Effects of caffeine ingestion on
exercise testing. Int. J. Sport Nutr. Exerc. Metab. 14: 626–646.
Ferrauti, A., Weber, K., and Struder, H.K. 1997. Metabolic and er-
gogenic effects of carbohydrate and caffeine beverages in tennis.
J. Sports Med. Phys. Fitness, 37: 258–266. PMID:9509824.
Fiala, K.A., Casa, D.J., and Roti, M.W. 2004. Rehydration with a
caffeinated beverage during the nonexercise periods of 3 conse-
cutive days of 2-a-day practices. Int. J. Sport Nutr. Exerc. Me-
tab. 14: 419–429. PMID:15467100.
Gonzalez-Alonso, J., Heaps, C.L., and Coyle, E.F. 1992. Rehydra-
tion after exercise with common beverages and water. Int. J.
Sports Med. 13: 399–406. PMID:1521958.
Graham, T.E. 2001a. Caffeine, coffee and ephedrine: impact on ex-
ercise performance and metabolism. Can. J. Appl. Physiol. 26:
S103–S109. PMID:11897887.
Graham, T.E. 2001b. Caffeine and exercise: metabolism, endurance
and performance. Sports Med. 31: 785–807. doi:10.2165/
00007256-200131110-00002. PMID:11583104.
Graham, T.E., and Spriet, L.L. 1995. Metabolic, catecholamine,
and exercise performance responses to various doses of caffeine.
J. Appl. Physiol. 78: 867–874. PMID:7775331.
Graham, T.E., Hibbert, E., and Sathasivam, P. 1998. Metabolic and
exercise endurance effects of coffee and caffeine ingestion. J.
Appl. Physiol. 85: 883–889. PMID:9729561.
Graham, T.E., Battram, D.S., Dela, F., El-Sohemy, A., and Thong,
F.S.L. 2008. Does caffeine alter muscle carbohydrate and fat
metabolism during exercise? Appl. Physiol. Nutr. Metab. 33:
this issue.
Hopkins, W.G., Hawley, J.A., and Burke, L.M. 1999. Design and
analysis of research on sport performance enhancement. Med.
Sci. Sports Exerc. 31: 472–485. doi:10.1097/00005768-1999
03000-00018. PMID:10188754.
Hunter, A.M., St Clair Gibson, A., Collins, M., Lambert, M., and
Noakes, T.D. 2002. Caffeine ingestion does not alter perfor-
mance during a 100-km cycling time-trial performance. Int. J.
Sport Nutr. Exerc. Metab. 12: 438–452. PMID:12500987.
International Olympic Committee. 2003. Olympic Movement Anti-
doping Code. Appendix A. Prohibited classes of substances and
prohibited methods 2003. International Olympic Committee,
Lausanne, Switzerland.
Ivy, J.L., Costill, D.L., Fink, W.J., and Lower, R.W. 1979. Influ-
ence of caffeine and carbohydrate feedings on endurance perfor-
mance. Med. Sci. Sports, 11: 6–11. PMID:481158.
Jacobson, T.L., Febbraio, M.A., Arkinstall, M.J., and Hawley, J.A.
2001. Effect of caffeine co-ingested with carbohydrate or fat on
metabolism and performance in endurance-trained men. Exp.
Physiol. 86: 137–144. doi:10.1113/eph8602072. PMID:11429627.
Jenkins, N.T., Trilk, J.L., Singhal, A., O’Connor, P.J., and Cureton,
K.J. 2008. Ergogenic effects of low doses of caffeine on cycling
performance. Int. J. Sport Nutr. Exerc. Metab. 18: 328–342.
Jones, G. 2008. Caffeine and other sympathomimetic stimulants:
modes of action and effects on sports performance. Essays Bio-
chem. 44: 109–123. doi:10.1042/BSE0440109. PMID:18384286.
Keisler, B.D., and Armsey, T.D. 2006. Caffeine as an ergogenic
aid. Curr. Sports Med. Rep. 5: 215–219. PMID:16822345.
Kovacs, E.M.R., Stegen, J.H.C.H., and Brouns, F. 1998. Effect of
caffeinated drinks on substrate metabolism, caffeine excretion,
and performance. J. Appl. Physiol. 85: 709–715. PMID:9688750.
MacIntosh, B.R., and Wright, B.M. 1995. Caffeine ingestion and
performance of a 1,500-metre swim. Can. J. Appl. Physiol. 20:
168–177. PMID:7640644.
McCusker, R.R., Goldberger, B.A., and Cone, E.J. 2003. Caffeine
content of specialty coffees. J. Anal. Toxicol. 27: 520–522.
Millard-Stafford, M.L., Cureton, K.J., Wingo, J.E., Trilk, J.,
Warren, G.L., and Buyckx, M. 2007. Hydration during exercise
in warm, humid conditions: effect of caffeinated sports drink.
Int. J. Sport Nutr. Exerc. Metab. 17: 163–177. PMID:17507741.
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A.,
and Feeley, M. 2003. Effects of caffeine on human health. Food
Addit. Contam. 20: 1–30. doi:10.1080/0265203021000007840.
Pasman, W.J., van Baak, M.A., Jeukendrup, A.E., and de Haan, A.
1995. The effect of different dosages of caffeine on endurance
performance time. Int. J. Sports Med. 16: 225–230. doi:10.
1055/s-2007-972996. PMID:7657415.
Paton, C.D., Hopkins, W.G., and Vollebregt, L. 2001. Little effect
of caffeine ingestion on repeated sprints in team-sport athletes.
Med. Sci. Sports Exerc. 33: 822–825. doi:10.1097/00005768-
200105001-00964. PMID:11323555.
Pedersen, D.J., Lessard, S.J., Coffey, V., Churchley, E.G., Wootton,
A.M., Ng, T., et al. 2008. High rates of muscle glycogen re-
synthesis after exhaustive exercise when carbohydrate is co-
ingested with caffeine. J. Appl. Physiol. 105: 7–13. doi:10.
1152/japplphysiol.01121.2007. PMID:18467543.
Pruscino, C.L., Ross, M.L., Gregory, J.R., Savage, B., and
Flanagan, T.R. 2008. The effects of sodium bicarbonate, caf-
feine and their combination on repeated 200-m freestyle perfor-
mance. Int. J. Sport Nutr. Exerc. Metab. 18: 116–130.
Schneiker, K.T., Bishop, D., Dawson, B., and Hackett, L.P. 2006.
Effects of caffeine on prolonged intermittent-sprint ability in
team-sport athletes. Med. Sci. Sports Exerc. 38: 578–585.
doi:10.1249/01.mss.0000188449.18968.62. PMID:16540848.
Strecker, E., Foster, E.B., Taylor, K., Bell, L., and Pascoe, D.D.
2007. The effect of caffeine and ingestion on tennis skill perfor-
mance and hydration status. Med. Sci. Sports Exerc. 39: S43.
Stuart, G.R., Hopkins, W.G., Cook, C., and Cairns, S.P. 2005. Mul-
tiple effects of caffeine on simulated high-intensity team sport
performance. Med. Sci. Sports Exerc. 37: 1998–2005. doi:10.
1249/01.mss.0000177216.21847.8a. PMID:16286872.
Burke 1333
#2008 NRC Canada
Tarnopolsky, M.A. 2008. Effect of caffeine on the neuromuscular
system — potential as an ergogenic aid. Appl. Physiol. Nutr.
Metab. 33: this issue.
van Dam, R.M., and Hu, F.B. 2005. Coffee consumption and risk
of type 2 diabetes: a systematic review. JAMA, 294: 97–104.
doi:10.1001/jama.294.1.97. PMID:15998896.
Van Nieuwenhoven, M.A., Brouns, F., and Kovacs, E.M.R. 2005. The
effect of two sports drinks and water on GI complaints and perfor-
mance during an 18-km run. Int. J. Sports Med. 26: 281–285.
doi:10.1055/s-2004-820931. PMID:15795812.
Van Thuyne, W., and Delbeke, F.T. 2006. Distribution of caffeine
levels in sport. Int. J. Sports Med. 27: 745–750. doi:10.1055/s-
2005-872921. PMID:16586337.
Van Thuyne, W., Roels, K., and Delbeke, F.T. 2005. Distribution
of caffeine levels in urine in different sports in relation to dop-
ing control. Int. J. Sports Med. 26: 714–718. doi:10.1055/s-
2005-837437. PMID:16237615.
Vergauwen, L., Brouns, F., and Hespel, P. 1998. Carbohydrate sup-
plementation improves stroke performance in tennis. Med. Sci.
Sports Exerc. 30: 1289–1295. doi:10.1097/00005768-199808000-
00017. PMID:9710871.
Wemple, R.D., Lamb, D.R., and McKeever, K.H. 1997. Caffeine
vs. caffeine-free sports drinks: effects on urine production at rest
and during prolonged exercise. Int. J. Sports Med. 18: 40–46.
doi:10.1055/s-2007-972593. PMID:9059904.
Wiles, J.D., Bird, S.R., Hopkins, J., and Riley, M. 1992. Effect of
caffeinated coffee on running speed, respiratory factors, blood
lactate and perceived exertion during 1500-m treadmill running.
Br. J. Sports Med. 26: 116–120. PMID:1623356.
Wiles, J.D., Coleman, D., Tegerdine, M., and Swaine, I.L. 2006. The
effects of caffeine ingestion on performance time, speed and
power during a laboratory-based 1 km cycling time-trial. J. Sports
Sci. 24: 1165–1171. doi:10.1080/02640410500457687. PMID:
1334 Appl. Physiol. Nutr. Metab. Vol. 33, 2008
#2008 NRC Canada
... Previous research has shown that high numbers of athletes consume some form of caffeine around competition . The potential benefits of caffeine supplementation have previously been documented Burke, 2008;Mielgo-Ayuso et al., 2019;Stadheim et al., 2021;Tallis et al., 2021). Although, some of these studies have tended to be laboratory-based investigations with less understanding of the effects of caffeine on physical and physiological performance in "real-world" settings. ...
... These include the enhancement of oxygen utilisation, increased carbohydrate utilisation, improved power performance, enhanced cognitive function, and increased time to fatigue (Hogervorst et al., 2008;Mielgo-Ayuso et al., 2019;Stadheim et al., 2021). However, it is important to note that the required dosage and timing of ingestion to attain these performance enhancements may vary between individuals (Burke, 2008). It is also important to consider the potential detrimental effects of consuming high amounts of caffeine. ...
... Considering the average weight of the participants, this represents approximately 1.8 mg/kg. This finding is in line with previous studies (Burke et al., 2008; that only found significant improvements in performance with higher dosages (>3 mg/kg). In fact, the lower dosages (<2 mg/kg) were not included in a systematic review on the effects of acute caffeine ingestion on team sports performance based on previous studies showing no effects of such low caffeine (Burke et al., 2008;Astorino et al., 2010;Turley et al., 2015). ...
Full-text available
The present study examined the effect of acute caffeine ingestion (150 mg) on the physical performance of elite European soccer players during official competitive match-play. The current investigation was a parallel-group design that collated data from a cohort of 19 male outfield players from an elite European soccer team (mean ± SD, age 26 ± 4 years; weight 80.5 ± 8.1 kg; height 1.83 ± 0.07 m; body-fat 10.8 ± 0.7%). Players were classified and matched by position and grouped accordingly: centre defender (CD) n = 5, wide defender (WD) n = 3, centre midfield (CM) n = 7, wide forward (WF) n = 2, and centre forward (CF) n = 2. For all performance variables, the mean values were compared in caffeine consumers vs. non consumers using independent-sample t-tests, with significance set at p < .05. Cohen’s d was used to quantify the effect size, and was interpreted as trivial (<0.2), small (0.2-0.5), medium (0.5-0.8), and large (>0.8). For all examined variables, there were trivial or small non-significant (p > .05) trivial or small differences between caffeine consumers and non-consumers. The findings of the present research did not confirm the study hypothesis, once running and accelerometry-based variables did not improve with the caffeine ingestion of 150 mg. Therefore, the caffeine supplement used in this study is not suggested for improving performance in the variables analysed.
... We also found that approximately half of the representative athletes in both the T-OG/T-PG and B-OG/B-PG groups did not check for the side effects of supplements or their interaction with other medications. Excessive caffeine consumption has been reported to worsen sleep and amplify symptoms such as nausea, anxiety, and insomnia (33). In addition, it is crucial to exercise caution and thoroughly check the potential short-and long-term effects of excessive intake of vitamins (particularly fat-soluble vitamins) and minerals, especially when combined with other medications, as the actual effects and the possibility of serious side effects are debated not only among the general population but also within the athletic community. ...
... Many studies have confirmed the side effects of using supplements (especially overdoses) (7,33,(35)(36)(37)(38)(39). Geyer and colleagues found that of 634 non-hormonal supplements purchased in 13 countries in 2000-2001, 15% were contaminated with anabolic-androgenic steroids not declared on the label (40). ...
Full-text available
Elite athletes frequently invest in the use of supplements to optimize their dietary regimens and enhance their athletic performance. However, unregulated and unplanned use of supplements can lead to adverse consequences, including anti-doping rule violations or health issues. Thus, athletes should verify their diets, consider scientific evidence, and take necessary precautions regarding supplements before use. To date, no study has explored whether athletes check these factors before using supplements. This study aimed to investigate supplement use using a questionnaire administered to 1,392 athletes (including candidate athletes) who participated in the Tokyo 2020 Olympic/Paralympic and Beijing 2022 Winter Olympic/Paralympic Games. Participants were categorized as follows: 1,040 participants in the Tokyo 2020 Olympic Games, 83 in the Tokyo 2020 Paralympic Games, 239 in the Beijing 2022 Winter Olympic Games, and 30 in the Beijing 2022 Winter Paralympic Games. We collected data on supplement use and gained further knowledge through interviews with the athletes. Approximately 70% of Tokyo 2020 Olympic/Paralympic and Beijing 2022 Winter Olympic athletes and approximately 50% of Beijing 2022 Winter Paralympians used supplements. Over 50% of athletes had not received a doctor's diagnosis or a dietitian's evaluation before supplement use. Moreover, only 50% of the athletes who used dietary supplements reviewed the scientific evidence for the dietary supplements before using them and justified their choice based on their own investigation, while those who did not use dietary supplements cited either a lack of need or fear of an anti-doping rule violation. Considering the holistic health and performance of athletes, as well as the risk associated with unregulated use, such as overdose and anti-doping rule violations, there is a need for nutritional education on supplement use for athletes and their entourages.
... Caffeine is a natural stimulant for the central nervous system, possesses various suggested benefits for enhancing performance and is one of the supplements with the highest scientific evidence supporting its use [15]. These advantages encompass enhanced neuromuscular functionality and a decrease in fatigue and perceived effort levels during physical exertion, among others [44]. The following most-consumed SS were sport drinks (formulated to provide a balanced combination of carbohydrates and liquids, facilitating athletes in rehydrating and replenishing energy simultaneously during and after their workout) and sport bars (created as a portable source of carbohydrates, helping meeting carbohydrate intake goals) [13], which also belong to Group A, such as caffeine. ...
Full-text available
Background: Middle-distance running events have special physiological requirements from a training and competition point of view. Therefore, many athletes choose to take sport supplements (SS) for different reasons. To date, few studies have been carried out that review supplementation patterns in middle-distance running. The aim of the present study is to analyze the consumption of SS in these runners with respect to their level of competition, sex and level of scientific evidence. Methods: In this descriptive cross-sectional study, data was collected from 106 middle-distance runners using a validated questionnaire. Results: Of the total sample, 85.85% responded that they consumed SS; no statistical difference was found regarding the level of competition or sex of the athletes. With respect to the level of competition, differences were observed in the total consumption of SS (p = 0.012), as well as in that of medical supplements (p = 0.005). Differences were observed between sexes in the consumption of medical supplements (p = 0.002) and group C supplements (p = 0.029). Conclusions: Higher-level athletes consume SS that have greater scientific evidence. On the other hand, although the most commonly consumed SS have evidence for the performance or health of middle-distance runners, runners should improve both their sources of information and their places of purchase.
... This may be due to the higher muscle mass and concentration of adenosine receptors in trained athletes [26,204]. Additionally, elite athletes are more reliable at performance and have a smaller coefficient of variation, which may allow for assessment of accurate effects of an intervention [205]. ...
... However, while there is evidence that caffeine improves athletic performance [173][174][175][176][177][178][179][180][181], due to particular protocols and study designs, some research seems conflicting. Some studies show ergogenic effects on aerobic endurance (>90 min), high-intensity efforts (20-60 min), muscular endurance, sprint performance and maximal strength (0 to 5 min), and ultra-endurance (>240 min) and endurance races with prolonged intermittent sprints (team sports), while others report no evidence for its administration [180][181][182]. ...
Full-text available
Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and energy drinks, and is widely consumed worldwide. Therefore, it is extremely important to research the effects of this substance on the human body. With this in mind, caffeine and its derivatives have been extensively studied to evaluate its ability to prevent diseases and exert anti-aging and neuroprotective effects. This review is intended to provide an overview of caffeine’s effects on cancer and cardiovascular, immunological, inflammatory, and neurological diseases, among others. The heavily researched area of caffeine in sports will also be discussed. Finally, recent advances in the development of novel nanocarrier-based formulations, to enhance the bioavailability of caffeine and its beneficial effects will be discussed.
... Es una metilxantina alcaloide, que se encuentra en la naturaleza en frutos, hojas, semillas, etc. y además en diversas bebidas y alimentos industrializados (café, bebidas energéticas, chocolate, etc.) (8). Es un estimulante, antes considerado doping por la World Anti-Doping Agency (WADA) y que se excluye de la lista de sustancias prohibidas desde el 2004 (9). ...
Full-text available
El rendimiento deportivo depende de múltiples componentes, entre ellos, algunos factores nutricionales como el uso de suplementos que pueden ser una herramienta útil para mejorarlo, pero en ocasiones son usados de manera incorrecta. El objetivo del presente artículo es informar a la comunidad médica y deportistas sobre los suplementos que son avalados por la evidencia científica actual, y estandarizar los criterios para su indicación en la práctica clínica. Se mencionan en este documento: cafeína, nitratos, beta alanina, creatina, y bicarbonato de sodio, junto a recomendaciones generales para la adecuada indicación y uso de dichos suplementos.
... Naukowcy udowodnili wpływ kofeiny na organizm sportowców. Jej działanie zależy od kondycji fizycznej, uprawianej dyscypliny sportowej i wysiłku podczas treningu [18]. Badania wykazały, że kofeina może wpływać korzystniej na osoby wytrenowane, mające lepszą adaptację do wysiłku i lepszą regulację gospodarki kwasowo-zasadowej [19,20]. ...
Full-text available
Na ilość spożywanej kawy przez konsumentów ma wpływ przede wszystkim jej niepowtarzalny, dość głęboki smak i delikatny aromat, w którym wyczuwalne są nuty korzenne lub czekoladowe oraz jej właściwości wynikające z zawartości kofeiny i polifenoli. Doniesienia naukowe wskazują, że umiarkowana konsumpcja kawy może być częścią zdrowej diety i aktywnego trybu życia, co wiąże się z szeregiem pożądanych zjawisk fizjologicznych w tym sprawności psychicznej i fizycznej. Artykuły naukowe przedstawiają szerokie spektrum pozytywnego wpływu cennych związków zawartych w tym napoju na organizm człowieka, zmniejszenie śmiertelnościz powodu chorób sercowo-naczyniowych, cukrzycy typu 2, jak również nowotworów czy też obniżeniu ryzyka zachorowalności na chorobę Parkinsona i Alzheimera. Jej dobroczynne właściwości wykorzystywane są również w kosmeteologii.
Caffeine is a very common kind of nervous stimulant, and it is primarily metabolized by Cytochrome P450 1A2 (CYP1A2) in the human body. Over the years, determining the interactions between caffeine and CYP1A2 has been a tough issue. The active binding modes and the catalytic regioselectivity of the metabolism between CYP1A2 and caffeine remain unclear. Here, to investigate the interactions between CYP1A2 and caffeine, we constructed the all-sequence CYP1A2-caffeine-membrane system using a multiple template approach. According to our simulation results, four active binding modes between CYP1A2 and caffeine that correspond to the four metabolic sites of caffeine are determined. What is more, a pre-reaction state for the CYP1A2-catalyzed reaction at caffeine's N3 site is identified. A more preponderant active binding mode might be the reason why the N3 site of caffeine becomes the primary metabolic site. Our findings could enhance our knowledge of the interactions between CYP1A2 and caffeine and help us better understand the regioselectivity of the metabolism between CYP1A2 and caffeine.
Full-text available
Caffeine is a common substance in the diets of most athletes and it is now appearing in many new products, including energy drinks, sport gels, alcoholic beverages and diet aids. It can be a powerful ergogenic aid at levels that are considerably lower than the acceptable limit of the International Olympic Committee and could be beneficial in training and in competition. Caffeine does not improve maximal oxygen capacity directly, but could permit the athlete to train at a greater power output and/or to train longer. It has also ben shown to increase speed and/or power output in simulated race conditions. These effects have been found in activities that last as little as 60 seconds or as long as 2 hours. There is less information about the effects of caffeine on strength; however, recent work suggests no effect on maximal ability, but enhanced endurance or resistance to fatigue. There is no evidence that caffeine ingestion before exercise leads to dehydration, ion imbalance, or any other adverse effects. The ingestion of caffeine as coffee appears to be ineffective compared to doping with pure caffeine. Related compounds such as theophylline are also potent ergogenic aids. Caffeine may act synergistically with other drugs including ephedrine and anti-inflammatory agents. It appears that male and female athletes have similar caffeine pharmacokinetics, i.e., for a given dose of caffeine, the time course and absolute plasma concentrations of caffeine and its metabolites are the same. In addition, exercise or dehydration does not affect caffeine pharmacokinetics. The limited information available suggests that caffeine non-users and users respond similarly and that withdrawal from caffeine may not be important. The mechanism(s) by which caffeine elicits its ergogenic effects are unknown, but the popular theory that it enhances fat oxidation and spares muscle glycogen has very little support and is an incomplete explanation at best. Caffeine may work, in part, by creating a more favourable intracellular ionic environment in active muscle. This could facilitate force production by each motor unit.
Full-text available
Metabolic and ergogenic effects of carbohydrate and caffeine concentrations, common in commercial available beverages, were investigated in 16 tournament players (8 males and 8 females) during a 4 hrs interrupted tennis match (30 min rest after 150 min). On three double-blind occasions players ingested a placebo (PLA), carbohydrate (CHO) or caffeine drink (CAF) at court changeover and during the resting period. In men (women) total intake consisted of 2.8 l (2.0 l) fluid, supplemented with 243 g (182 g) carbohydrates (CHO) or with 364 mg (260 mg) caffeine (CAF), respectively. Postexercise all players performed a ball-machine test (BMT) and a tennis-sprint test (TST). During match play blood glucose (GLU) was higher in CHO and did not differ between CAF and PLA. Immediately after the resting period GLU temporary declined in CHO and PLA, while no significant changes occurred in CAF. Increases of serum FFA and glycerol as well as the decrease of insulin were similar during the PLA and CAF trials and less pronounced in CHO. Postexercise urine concentrations of epinephrine and caffeine were significantly higher in CAF. Perception ratings and hitting accuracy (BMT) were not affected by treatment. CHO resulted in higher blood lactate levels during match play and a better post-exercise sprint performance (TST). Under CAF women won significantly more games than during both other treatments. CHO enhances tennis-specific running-speed but has no ergogenic effect on tennis performance under the conditions of our study. CAF improves glucose homeostasis at the beginning of work load after rest and may increase tennis success in women.
Full-text available
This investigation determined if 3 levels of controlled caffeine consumption affected fluid-electrolyte balance and renal function differently. Healthy males (mean standard deviation; age, 21.6 +/- 3.3 y) consumed 3 mg caffeine (.) kg(-1) (.) d(-1) on days I to 6 (equilibration phase). On days 7 to 11 (treatment phase), subjects consumed either 0 mg (CO; placebo; n = 20), 3 mg (C3; n = 20), or 6 mg (C6; n = 19) caffeine (.) kg(-1) (.) d(-1) in capsules, with no other dietary caffeine intake. The following variables were unaffected (P > 0.05) by different caffeine doses on days 1, 3, 6, 9, and 11 and were within normal clinical ranges: body mass, urine osmolality, urine specific gravity, urine color, 24-h urine volume, 24-h Na+ and K+ excretion, 24-h creatinine, blood urea nitrogen, serum Na+ and K+, serum osmolality, hematocrit, and total plasma protein. Therefore, C0, C3, and C6 exhibited no evidence of hypohydration. These findings question the widely accepted notion that caffeine consumption acts chronically as a diuretic.
Full-text available
A study of a sample provides only an estimate of the true (population) value of an outcome statistic. A report of the study therefore usually includes an inference about the true value. Traditionally, a researcher makes an inference by declaring the value of the statistic statistically significant or nonsignificant on the basis of a P value derived from a null-hypothesis test. This approach is confusing and can be misleading, depending on the magnitude of the statistic, error of measurement, and sample size. The authors use a more intuitive and practical approach based directly on uncertainty in the true value of the statistic. First they express the uncertainty as confidence limits, which define the likely range of the true value. They then deal with the real-world relevance of this uncertainty by taking into account values of the statistic that are substantial in some positive and negative sense, such as beneficial or harmful. If the likely range overlaps substantially positive and negative values, they infer that the outcome is unclear; otherwise, they infer that the true value has the magnitude of the observed value: substantially positive, trivial, or substantially negative. They refine this crude inference by stating qualitatively the likelihood that the true value will have the observed magnitude (eg, very likely beneficial). Quantitative or qualitative probabilities that the true value has the other 2 magnitudes or more finely graded magnitudes (such as trivial, small, moderate, and large) can also be estimated to guide a decision about the utility of the outcome.
Recreational enthusiasts and athletes often are advised to abstain from consuming caffeinated beverages (CB). The dual purposes of this review are to (a) critique controlled investigations regarding the effects of caffeine on dehydration and exercise performance, and (b) ascertain whether abstaining from CB is scientifically and physiologically justifiable. The literature indicates that caffeine consumption stimulates a mild diuresis similar to water, but there is no evidence of a fluid-electrolyte imbalance that is detrimental to exercise performance or health. Investigations comparing caffeine (100-680 mg) to water or placebo seldom found a statistical difference in urine volume. In the 10 studies reviewed, consumption of a CB resulted in 0-84% retention of the initial volume ingested, whereas consumption of water resulted in 0-81% retention. Further, tolerance to caffeine reduces the likelihood that a detrimental fluid-electrolyte imbalance will occur. The scientific literature suggests that athletes a...
Conference Paper
Purpose: The purpose of this study was to assess research aimed at measuring performance enhancements that affect success of individual elite athletes in competitive events. Analysis: Simulations show that the smallest worthwhile enhancement of performance for an athlete in an international event is 0.7-0.4 of the typical within-athlete random variation in performance between events. Using change in performance in events as the outcome measure in a crossover study, researchers could delimit such enhancements with a sample of 16-65 athletes, or with 65-260 in a fully controlled study. Sample size for a study using a valid laboratory or field test is proportional to the square of the within-athlete variation in performance in the test relative to the event; estimates of these variations are therefore crucial and should be determined by repeated-measures analysis of data from reliability studies for the test and event. Enhancements in test and event may differ when factors that affect performance differ between test and event; overall effects of these factors can be determined with a validity study that combines reliability data for test and event. A test should be used only if it is valid, more reliable than the event, allows estimation of performance enhancement in the event, and if the subjects replicate their usual training and dietary practices for the study; otherwise the event itself provides the only dependable estimate of performance enhancement. Publication of enhancement as a percent change with confidence limits along with an analysis for individual differences will make the study more applicable to athletes. Outcomes can be generalized only to athletes with abilities and practices represented in the study. Conclusion: estimates of enhancement of performance in laboratory or field tests in most previous studies may not apply to elite athletes in competitive events.
The purpose of this study was to assess the influence of rehydration with a caffeinated beverage during nonexercise periods on hydration status throughout consecutive practices in the heat. Ten (7 women, 3 men) partially heat-acclimated athletes (age 24 +/- 1y, body fat 19.2 +/- 2%, weight 68.4 +/- 4.0 kg, height 170 3 cm) completed 3 successive days of 2-a-day practices (2 h/ practice, 4 h/d) in mild heat (WBGT = 23degreesC). The 2 trials (double-blind, random, cross-over design) included; 1) caffeine (CAF) rehydrated with Coca-Cola(R) and 2) caffeine-free (CF) rehydrated with Caffeine-Free Coca-Cola(R) Urine and psychological measures were determined before and after each 2-h practice. A significant difference was found for urine color for the post-AM time point, F = 5.526, P = 0.031. No differences were found among other variables (P > 0.05). In summary, there is little evidence to suggest that the use of beverages containing caffeine during nonexercise might hinder hydration status.
Recreational enthusiasts and athletes often are advised to abstain from consuming caffeinated beverages (CB). The dual purposes of this review are to (a) critique controlled investigations regarding the effects of caffeine on dehydration and exercise performance, and (b) ascertain whether abstaining from CB is scientifically and physiologically justifiable. The literature indicates that caffeine consumption stimulates a mild diuresis similar to water, but there is no evidence of a fluid-electrolyte imbalance that is detrimental to exercise performance or health. Investigations comparing caffeine (100-680 mg) to water or placebo seldom found a statistical difference in urine volume. In the 10 studies reviewed, consumption of a CB resulted in 0-84% retention of the initial volume ingested, whereas consumption of water resulted in 0-81% retention. Further, tolerance to caffeine reduces the likelihood that a detrimental fluid-electrolyte imbalance will occur. The scientific literature suggests that athletes and recreational enthusiasts will not incur detrimental fluid-electrolyte imbalances if they consume CB in moderation and eat a typical U.S. diet. Sedentary members of the general public should be at less risk than athletes because their fluid losses via sweating are smaller.
We investigate numerical simulations that utilize a nonlinear interdiffusion solver and dynamical x-ray diffraction calculations to predict the local composition evolution in low Ge concentration Si/SiGe superlattices and their diffraction patterns during annealing. Superlattice satellite peak decay rates are compared with experimentally measured values and simulated diffraction patterns are matched directly to data with good success. The simulations are used to test the sensitivity of x-ray diffraction to various uncertainties commonly encountered when measuring interdiffusion at Si/SiGe interfaces. It is found that the most serious errors result from variations in the Ge content across the surface of the wafer. For example, the resolution limit of most experimental techniques used to measure Ge concentration in a SiGe film is ±1 at. %, for a film with 11% mean Ge concentration annealed for 5 h at 870 °C, this level of error will cause the observed interdiffusivity values to deviate by −25% or +50%. The simulations are further used to show that for Si/SiGe interdiffusion, superlattice diffraction produces valid measurements when applied to 004 superlattice satellite peaks and square wave composition modulations even though it is only exactly applicable to satellite peaks about 000 reflections and to sinusoidal composition modulations. Finally, we show that proper interpretation of x-ray scattering data to extract Si/SiGe interdiffusivity values must account for the strong dependence of the interdiffusivity on Ge concentration. © 2003 American Institute of Physics.