Article

NRAS mutant melanoma - undrugable?

University of California San Francisco, Department for Dermatology, Mt. Zion Cancer Research Center, California, USA.
Oncotarget (Impact Factor: 6.36). 04/2013; 4(4):494-5. DOI: 10.18632/oncotarget.970
Source: PubMed

ABSTRACT

Mutations in the three rat sarcoma (RAS) family members NRAS (neuroblastoma-RAS), HRAS (Harvey-RAS) and KRAS (Kirsten-RAS) are found in one third of human cancers. Among the first oncogenes discovered in cutaneous melanoma was NRAS, which is mutant in up to 20% of tumors causing aberrant signaling in several downstream cascades. Despite, being a highly relevant therapeutic target, design of small molecules selectively inhibiting mutant NRAS in melanoma, to date, remains an unsolved challenge. The end?

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Available from: Christian Posch, Mar 14, 2014
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    • "NRAS Q61R appears to be the more frequent NRAS mutation in melanoma with about 40– 67 % to of NRAS mutations [20, 24]. NRAS targeting is a new field in melanoma treatment and there is no consensus on the NRAS inhibitors to date25262728 . Nevertheless , the determination of NRAS mutational status is already of interest in melanoma treatment strategies. "
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    • "Signaling pathways activated in melanoma. and 13 prevent the association of GAP proteins with the NRAS complex [21]. Association with the inner face of the plasma membrane is necessary for RAS function. "
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