DSM-IV: Diagnostic and Statistical Manual of Mental Disorders-IV; EQ-
5D: EuroQol- 5 dimensions; GPs: General Practices; HADS-A: Hospital Anxiety
and Depression Scale-A; ICC: Intraclass correlation; ICERs: Incremental Cost-
Effectiveness Ratios; ICPC: International Classification of Primary Care; LDL
cholesterol: Low-Density Lipoprotein cholesterol; PHQ-2: Patient Health
Questionnaire-2; PHQ-9: Patient Health Questionnaire- 9; PST: Problem
The authors declare that they have no competing interests.
SvD constructed the design of the study and drafted the manuscript. AP
constructed the design of the study and revised the manuscript. MCA, JB,
PE and HvM developed the study, constructed the design and revised the
manuscript. MvT participated in the design of the study and revised the
manuscript. The final manuscript was read and approved by all authors.
Acknowledgements and funding
This study is funded by ZonMw, the Netherlands Organisation for Health
Research and Development (project number 80-82310-97-12110). Publication
in this Open Access journal was funded by NWO, the Netherlands
Organisation for Scientific Research.
The Authors would like to thank Hanna Joosten, data manager at the
Department of General Practice, VU University Medical Centre, Amsterdam,
for helping us out by estimating the feasibility of the trial based on a
registration sample of the Academic Network of General Practitioners (GPs)
of the Department of General practice of the VU medical centre.
Department of Health Sciences and the EMGO institute for Health and Care
research, Faculty of Earth and Life Sciences, VU University Amsterdam, De
Boelelaan 1085, 1081, HV, Amsterdam, The Netherlands.
General Practice and the EMGO institute for Health and Care research, VU
University Medical Centre, Amsterdam, The Netherlands.
Received: 10 April 2013 Accepted: 24 April 2013
Published: 7 May 2013
1. Smits F, Smits N, Schoevers R, Deeg D, Beekman A, Cuijpers P: An
epidemiological approach to depression prevention in old age.
Am J Geriatr Psychiatr 2008, 16:444–453.
2. Cuijpers P, Van Straten A, Smit F, Mihalopoulos C, Beekman A: Preventing
the onset of depressive disorders: a meta-analytic review of
psychological interventions. Am J Psychiatr 2008, 165:1272– 1280.
3. Mathers CD, Loncar D: Projections of global mortality and burden of
disease from 2002 to 2030. PLoS Med 2006, 3:e442.
4. de Graaf R, ten Have M, van Gool C, van Dorsselaer S: Prevalence of mental
disorders and trends from 1996 to 2009. Results from the Netherlands
Mental Health Survey and Incidence Study-2. Soc Psychiatr Psychiatr
Epidemiol 2012, 47:203–213.
5. Kessler RC, Ustun T (Eds): The WHO World Mental Health Surveys. Cambridge:
Cambridge University Press; 2008.
6. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ: The prevalence of
comorbid depression in adults with diabetes. Diabetes Care 2001,
7. Härter M, Baumeister H, Reuter K, Jacobi F, Höfler M, Bengel J, Wittchen HU:
Increased 12-month prevalence rates of mental disorders in patients
with chronic somatic diseases. Psychother Psychosom 2007, 76:354–360.
8. Rudisch B, Nemeroff CB: Epidemiology of comorbid coronary artery
disease and depression. Biol Psychiatr 2003, 54:227–240.
9. Bot M, Pouwer F, Ormel J, Slaets JPJ, De Jonge P: Predictors of incident
major depression in diabetic outpatients with subthreshold depression.
Diabet Med 2010, 27:1295–1301.
10. Thombs BD, Bass EB, Ford DE, Stewart KJ, Tsilidis KK, Patel U, Fauerbach JA,
Bush DE, Ziegelstein RC: Prevalence of depression in survivors of acute
myocardial infarction. J Gen Intern Med 2006, 21:30 –38.
11. Hance M, Carney RM, Freedland KE, Skala J: Depression in patients with
coronary heart disease: A 12-month follow-up. Gen Hosp Psychiatr 1996,
12. Gehi A, Haas D, Pipkin S, Whooley MA: Depression and medication
adherence in outpatients with coronary heart disease: findings from the
Heart and Soul Study. Arch Int Med 2005, 165:2508
13. Lin EHB, Katon W, Von Korff M, Rutter C, Simon GE, Oliver M, Ciechanowski
P, Ludman EJ, Bush T, Young B: Relationship of depression and diabetes
self-care, medication adherence, and preventive care. Diabetes Care 2004,
14. Ruo B, Rumsfeld JS, Hlatky MA, Liu H, Browner WS, Whooley MA:
Depressive symptoms and health-related quality of life: the heart and
soul study. JAMA 2003, 290:215–221.
15. Ali S, Stone M, Skinner TC, Robertson N, Davies M, Khunti K: The association
between depression and health-related quality of life in people with
type 2 diabetes: a systematic literature review. Diabetes Metab Res Rev
16. Lin EHB, Heckbert SR, Rutter CM, Katon WJ, Ciechanowski P, Ludman EJ,
Oliver M, Young BA, McCulloch DK, Von Korff M: Depression and increased
mortality in diabetes: unexpected causes of death. Ann Fam Med 2009,
17. Katon W, Lin EHB, Von Korff M, Ciechanowski P, Ludman E, Young B, Rutter
C, Oliver M, McGregor M: Integrating depression and chronic disease care
among patients with diabetes and/or coronary heart disease: the design
of the TEAMcare study. Contemp Clin Trials 2010, 31:312–322.
18. Simon GE, Katon WJ, Lin EHB, Ludman E, VonKorff M, Ciechanowski P,
Young BA: Diabetes complications and depression as predictors of
health service costs. Gen Hosp Psychiatr 2005, 27:344–351.
19. Rutledge T, Vaccarino V, Johnson BD, Bittner V, Olson MB, Linke SE, Cornell
CE, Eteiba W, Sheps DS, Francis J, et al: Depression and cardiovascular
health care costs among women with suspected myocardial ischemia:
prospective results from the WISE (Women's Ischemia Syndrome
Evaluation) Study. J Am Coll Cardiol 2009, 53:176–183.
20. Bosmans JE, Adriaanse MC: Outpatient costs in pharmaceutically treated
diabetes patients with and without a diagnosis of depression in a Dutch
primary care setting. BMC Health Serv Res 2012, 12:46.
21. Egede LE, Zheng D, Simpson K: Comorbid depression is associated with
increased health care use and expenditures in individuals with diabetes.
Diabetes Care 2002, 25:464–470.
22. Smit F, Willemse G, Koopmanschap M, Onrust S, Cuijpers P, Beekman A:
Cost-effectiveness of preventing depression in primary care patients.
Br J Psychiatr 2006, 188:330–336.
23. Andrews G, Issakidis C, Sanderson K, Corry J, Lapsley H: Utilising survey
data to inform public policy: comparison of the cost-effectiveness of
treatment of ten mental disorders. Br J Psychiatr 2004, 184:
24. Cuijpers P, Beekman ATF, Reynolds CF: Preventing depression: a global
priority. JAMA 2012, 307:1033–1034.
25. Muñoz RF, Cuijpers P, Smit F, Barrera AZ, Leykin Y: Prevention of major
depression. Annu Rev Clin Psychol 2010, 6:181–212.
26. van't Veer-Tazelaar PJ, van Marwijk HWJ, van Oppen P, van Hout HPJ, van
der Horst HE, Cuijpers P, Smit F, Beekman ATF: Stepped-care prevention of
anxiety and depression in late life: a randomized controlled trial.
Arch Gen Psychiatr 2009, 66:297–304.
27. van't Veer-Tazelaar PJ, van Marwijk HW, van Oppen P, van der Horst HE,
Smit F, Cuijpers P, Beekman AT: Prevention of late-life anxiety and
depression has sustained effects over 24 months: a pragmatic
randomized trial. Am J Geriatr Psychiatr 2011, 19:230–239.
28. Katon WJ, Von Korff M, Lin EHB, Simon G, Ludman E, Russo J, Ciechanowski
P, Walker E, Bush T: The Pathways Study: a randomized trial of
collaborative care in patients with diabetes and depression. Arch Gen
Psychiatr 2004, 61:1042–1049.
29. Katon WJ, Russo JE, Von Korff M, Lin EHB, Ludman E, Ciechanowski PS:
Long-term effects on medical costs of improving depression outcomes in
patients with depression and diabetes. Diabetes Care 2008, 31:1155–1159.
30. Katon W, Unützer J, Fan MY, Williams JW Jr, Schoenbaum M, Lin EHB,
Hunkeler EM: Cost-effectiveness and net benefit of enhanced treatment
of depression for older adults with diabetes and depression. Diabetes
Care 2006, 29:265–270.
31. Katon WJ, Lin EHB, Von Korff M, Ciechanowski P, Ludman EJ, Young B,
Peterson D, Rutter CM, McGregor M, McCulloch D: Collaborative care for
patients with depression and chronic illnesses. N Engl J Med 2010,
32. Kroenke K, Spitzer RL: The PHQ-9: a new depression diagnostic and
severity measure. Psychiatr Ann 2002, 32:509–515.
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