Seroprevalence of celiac disease among healthy adolescents in Saudi Arabia

Article (PDF Available)inWorld Journal of Gastroenterology 19(15):2374-8 · April 2013with34 Reads
DOI: 10.3748/wjg.v19.i15.2374 · Source: PubMed
Abstract
To identify the seroprevalence of celiac disease among healthy Saudi adolescents. Between December 2007 and January 2008, healthy students from the 10(th) to 12(th) grades were randomly selected from three regions in Saudi Arabia. These regions included the following: (1) Aseer region, with a student population of 25512; (2) Madinah, with a student population of 23852; and (3) Al-Qaseem, with a student population of 16067. Demographic data were recorded, and a venous blood sample (5-10 mL) was taken from each student. The blood samples were tested for immunoglobulin A and immunoglobulin G endomysial antibodies (EMA) by indirect immunofluorescence. In total, 1167 students (614 males and 553 females) from these three regions were randomly selected. The majority of the study population was classified as lower middle class (82.7%). There were 26 (2.2%) students who had a positive anti-EMA test, including 17 females (3.1%) and 9 males (1.5%). Al-Qaseem region had the highest celiac disease prevalence among the three studied regions in Saudi Arabia (3.1%). The prevalence by region was as follows: Aseer 2.1% (10/479), Madinah 1.8% (8/436), and Al-Qaseem 3.2% (8/252). The prevalence in Madinah was significantly lower than the prevalence in Aseer and Al-Qaseem (P = 0.02). Our data suggest celiac disease prevalence might be one of the highest in the world. Further studies are needed to determine the real prevalence.
    • "For all of these reasons, GFD causes significant socio-economic impact on children with CD and their families, which subsequently , affects their quality of life [1][2][3][4][5]. In Saudi Arabia, there are no large data about the prevalence of CD; however, several studies found a sero-prevalence rate between 1-4%, making Saudi Arabia one of the countries with a high prevalence rate of CD [6][7][8], furthermore, children less than 14 years of age account for 29% of the total number of the Saudi population (30.9 million) [9], with such high percentage of young population, high prevalence rate of CD among children is expected. We have recently shown that Saudi children have relatively poor compliance to GFD compared to those from other countries [10] . "
    [Show abstract] [Hide abstract] ABSTRACT: Purpose To determine the socio-economic impact of gluten free diet (GFD) on Saudi children and their families. Methods A cross-sectional study was conducted in which an online questionnaire was sent to all families registered in the Saudi celiac patients support group. We included only children (age 18 years of age and younger) with biopsy-confirmed celiac disease (CD). Results A total of 113 children were included in the final analysis, the median age was 9.9 years; 62.8% were females. One hundred (88.5%) of the participating families reported that GFD food was not easily available in their areas, 17% of them reported that it was not available at all in their area. One hundred and six (93.8%) reported that the price of GFD food was very expensive and 70 (61.9%) families that the diet was heavily affecting their family budget. Significant social difficulties were reported among the participating families and their children including interference with the child's interaction with other children (49.6%), the families' ability to attend social gatherings (60.2%), the families' ability to eat in restaurants (73.5%), and the families' ability to travel (58.4%). Conclusion There is significant negative socio-economic impact of GFD on children with CD & their families. Health care providers should be aware of these psycho-social difficulties and be well trained to provide a proper education and psychological support for these patients and their families.
    Full-text · Article · Sep 2016
    • "[4] So at least we would say that such a statement is open to debate. In addition we wanted to point out that the study by Aljebreen et al. [2] was conducted on a population of adolescents that were attending schools in different regions of the kingdom thus the author's statement that his study would be the first of its kind would be inaccurate. Again we commend the author on his effort and believe that his study has an added value to the region. "
    Full-text · Article · Jan 2016
    • "[19] Al Jabreen et al. reported the seroprevalence of CD among healthy adolescents in Saudi Arabia by region as follows: Aseer 2.1%, Madinah 1.8%, and Al‑Qaseem 3.2%. [4] The sample size was 1167 out of the school population of 65,431. "
    [Show abstract] [Hide abstract] ABSTRACT: Background/aim: Epidemiological studies of celiac disease (CD) among Saudi children have been performed only within some groups who are at a high risk of developing CD. The aim of this study was to determine the prevalence of CD among symptom-free children from the public schools of the military campus of National Guard in the Eastern Province of Saudi Arabia. Patients and methods: Between 2012 and 2014, serum samples were collected from 1141 students (age 6-18 years) attending nine public schools of the military campus of National Guard in the Eastern Province of Saudi Arabia. Participants were screened for CD by testing for anti-tissue transglutaminase IgA (IgA-tTG) and IgG antibodies (IgG-tTG). Small intestinal biopsy was offered to all participants who tested positive for IgA-tTG [IgA-tTG >20 relative units (RU)/ml]. Results: Of the 1141 participants, 32 were IgA-tTG positive. Thus, the estimated serology-positive prevalence was 3%. An intestinal biopsy was performed in 10 of the participants with antibody positivity. The biopsy findings of all 10 children were consistent with CD. Thus, the estimated biopsy-confirmed prevalence was about 1%. Conclusions: The prevalence of CD was estimated to be about 1% among symptom-free children from the public schools of the military campus of National Guard in the Eastern Province of Saudi Arabia.
    Full-text · Article · Dec 2015
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