Effect of Chinese herbs on immunoglobulin A nephropathy: a randomized controlled trial

The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Journal of Traditional Chinese Medicine (Impact Factor: 0.72). 02/2013; 33(1):65-9. DOI: 10.1016/S0254-6272(13)60102-8
Source: PubMed


The accumulation of extracellular matrix (ECM) is one of the main causes of renal fibrosis. Emerging evidence suggests that the metabolic enzyme of ECM is associated with renal fibrosis. In this study, we applied randomly controlled trial to check the curative effect of Chinese herbs on patients with immunoglobulin A nephropathy (IgAN).
Twenty-six patients were randomly divided into group A (control group) treated with Western Medicine and group B (treatment group) treated with combination of Traditional Chinese Medicine (TCM) and Western Medicine. Blood and urine tests were done before treatment and after 8-week treatment.
The levels of the main composition of extracellular matrix (MC-ECM), the metabolic enzyme of ECM (ME-ECM) and some cytokines in group B decreased more obviously than those in group A after 8-week treatment. So did the level of 24-hour urine protein. However, Metal matrix protease (MMP)-2 and vascular endothelial growth factor in group B increased more obviously than those in group A after 8-week treatment. No effects on the renal function were found in both groups.
Our study provided important information on using the combination of TCM with Western Medicine to inhibit the progression of renal fibrosis in patients with IgAN.

Full-text preview

Available from:
  • [Show abstract] [Hide abstract]
    ABSTRACT: Danmo Capsule (DMC) is a patent Chinese botanic drug, widely used in combinational therapy with prednisone in China to treat renal diseases. The combined therapy regimen can reduce the dosage of glucocorticoids and relieve symptoms of glucocorticoid related adverse drug effects. Previous study from our laboratory showed that co-administration of the DMC significantly increased the plasma Cmax and AUC of glucocorticoid in rats. However, the effect of DMC on prednisone/prednisolone tissue distribution remains unclear. Therefore, the purpose of the current research was to study the tissue distribution of prednisone/prednisolone in rats after DMC was co-administered. Rats were treated with control vehicle or DMC (0.432 g kg-1) for 14 days before prednisone acetate (42 mg kg-1) was orally given. Samples from the heart, liver, spleen, lung, kidney, brain, fat, muscle, testes, small intestine and thymus were collected at different time points. The concentrations of prednisone and prednisolone were determined by high-performance liquid chromatography. Compared with prednisone alone group, the prednisone concentrations in rat lung, kidney, heart, muscle, small intestine and fat were increased in DMC treated groups, while those in liver, spleen, brain and thymus were decreased. However, the prednisolone concentrations in liver, lung, small intestine and thymus were increased, while those in kidney, fat, muscle, testes and heart were decreased following DMC pre-treatment. These results indicated that the alteration of prednisone/prednisolone levels in important tissues, when DMC was co-administered, may contribute to the effect of DMC in reducing adverse drug reactions of glucocorticoid and lowering its dosage administered.
    No preview · Article · Jul 2015