JID VisualDx Quiz
1 Journal of Investigative Dermatology (2013), Volume 133
© 2013 The Society for Investigative Dermatology
1. What is your diagnosis?
a. Eosinophilic fasciitis.
d. Nephrogenic systemic fibrosis.
e. Graft-versus-host disease.
JID VisualDx Quiz: May 2013
Sadegh Amini1 and Robert S. Kirsner1
Journal of Investigative Dermatology (2013) 133, e4; doi:10.1038/jid.2013.123
1Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
image appears with permission from VisualDx. © Logical Images, Inc.
JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating
diagnostic images from VisualDx’s vast database. Questions relate to the image as well
as to selected articles in JID, which are listed after Question 1. Answers will be posted as
supplementary material. We hope you enjoy this challenge.
JID VisualDx Quiz
2 Journal of Investigative Dermatology (2013), Volume 133
MEchaNISM Of fIbrOSIS IN SclErOdErMa: TOPiC ARTiCLES
The questions below relate to the following article(s):
Ghosh AK, Bhattacharyya S, Lafyatis R et al. (2013) p300 is elevated in systemic sclerosis and its expression
is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis. J Invest Dermatol
2. Which of the following names is associated with a scoring system
3. Which of the following is consistent with the role of p300 in promoting fibrosis in
a. It is downregulated by TGf-β.
b. It has increased expression in cytoplasm of fibroblasts of patients with
c. It is dependent on Smads.
d. It is dependent on acetyltransferase activity to exert TGf-β’s effect.
e. all of the above.
Answers to the questions are available in the supplementary material online.
Supplementary material is available at http://dx.doi.org/10.1038/jid.2013.123
Additional images related to this condition and the differential diagnosis may be
found at http://info.visualdx.com/l/11412/2013-03-05/rpvhd.