Evaluation of array comparative genomic hybridization in recurrent miscarriage
Department of Gynaecology, Liverpool Women's Hospital, Liverpool L8 7SS.British journal of hospital medicine (London, England: 2005) (Impact Factor: 0.38). 04/2013; 74(1):36-40. DOI: 10.12968/hmed.2013.74.1.36
Chromosomal analysis of a failed pregnancy following the diagnosis of recurrent miscarriage is not standard practice yet an abnormal karyotype is one of the commonest causes. Array comparative genomic hybridization heralds a new and improved era of cytogenetics, which may prevent unnecessary interventions for patients.
Article: Mid-Trimester Pregnancy Loss[Show abstract] [Hide abstract]
ABSTRACT: Mid-trimester pregnancy loss (MTL) occurs between 12 and 24 weeks' gestation. The true incidence of this pregnancy complication is unknown, because research into MTL in isolation is scarce, although the estimated incidence has been noted to be 2% to 3% of pregnancies. A comprehensive preconceptual screening protocol is recommended, because the cause for an MTL may be present in isolation or combined (dual pathology), and is often heterogeneous. Patients with a history of MTL are at an increased risk of future miscarriage and preterm delivery. This risk is increased further depending on the number of associative factors diagnosed.
- [Show abstract] [Hide abstract]
ABSTRACT: The authors report a case of a 61-year-old woman diagnosed with large bladder diverticulum. Diagnosis was performed only after a series of investigations carried out for the occasional finding of hypercreatininaemia. Although the significant volumes of post void residual (PVR) and the relevant urine stagnation in the diverticulum, subjective symptomatology was absent and urinalysis and urine culture were negative. The scheduled therapeutic plan consisted of fosfomycin three grams every ten days for sixmonths, self-catheterization twice a day, voiding on a time schedule, and adequate fluid intake. The monthly scheduled follow-up at one year showed good general health, good compliance with the therapy, no urinary tract infections, a decrease in creatininemia to 1.2 mg/dl, and regression of nephrohydrosis to a mild stage. In conclusion, the absence of symptoms and negative urinalysis or urine culture allows expectant management despite the considerable size of the bladder diverticulum.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.