Ovary involvement of diffuse large B-cell lymphoma
Rong Hu, Miao Miao, Rong Zhang, Yingchun Li, Jia Li, Ke Zhu, Ying Yang,
Zhuogang Liu, Wei Yang
Department of Hematology, Shengjing Hospital, China Medical University, China
Background: Primary ovarian non-Hodgkin’s lymphoma (PONHL) is an uncommon entity; its pathology is usu-
ally diffuse large B cell lymphoma (DLBCL).
Case Reports: We report 3 cases of ovary involvement of DLBCL, 1 of which rapidly developed to central nervous
system involvement. Diagnosis and subsequent treatment are discussed and the literature on the
origin, epidemiology, clinical presentation, diagnosis, treatment and prognosis of ovary lympho-
ma are reviewed. All patients were diagnosed as having DLBCL after ovary biopsy, and were subse-
quently given regular chemotherapy. Two of them obtained remission and 1 of them had central
nervous system involvement.
Conclusions: Ovary involvement of DLBCL is rare; prognosis is related to the overall clinical manifestation and
some serum biomarkers. Diagnosis is established by ovary biopsy. Inaccurate or delayed diagnosis
is often due to the lesions presenting as a mass resembling ovary cancer and may lead to poor out-
come. Treatment regimen mainly consists of chemotherapy (CHOP) associated with rituximab.
Intrathecal chemotherapy may play an important role in prevention of central nervous system
key words:? ovary?•?DLBCL-lymphoma?•?central?nervous?system?(CNS)?•?intrathecal?chemotherapy
Author’s address: Wei Yang, Department of Hematology, Shengjing Hospital, China Medical University, China,
© Am J Case Rep, 2012; 13: 96-98