Pd catalysts offer additional advantages when used in combination with biological bottom-up synthesis: in particular, as well as the sustainable production, size-controlled formation in natural or artificial membrane entities, and stabilization and binding to functional groups inherent to this type of synthesis, the catalysis of organohalogen compound detoxification reactions opens up further ... [Show full abstract] possibilities, especially when considering factors such as metal recycling and re-use. Chemical synthesis methods can generate palladium catalysts of high purity and catalytic activity, providing that the starting substances are equally pure. “Biogenic” pathways may represent a sustainable and environmentally sound alternative for synthesis of precious metal nanocatalysts, especially for recycling approaches, the selective palladium recovery from multi-metal mixtures, and simultaneous nanoparticle production. Such methods may also provide novel solutions for protection of catalysts. This chapter presents ideas, strategies, and historical background concerning abiotically and biologically generated particles, their performance and how these can learn from each other.