Can hepatocellular carcinoma (HCC) produce unconventional metastases? Four cases of extrahepatic HCC

Tumori 04/2013; 99(1):19e-23e. DOI: 10.1700/1248.13806
Source: PubMed


Aims and background:
Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing.

Methods and study design:
We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible.

Results and conclusions:
These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.

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Available from: Vincenza Granata, Jun 12, 2014
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