Article

Co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection and AIDS

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of Kwazulu-Natal, Umbilo Road, Umbilo, Durban, KwaZulu-Natal, South Africa, 4001.
Cochrane database of systematic reviews (Online) (Impact Factor: 6.03). 03/2013; 3(3):CD005481. DOI: 10.1002/14651858.CD005481.pub3
Source: PubMed

ABSTRACT

The primary objective of this review was to evaluate the antiviral efficacy of co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection. The secondary objectives were to evaluate the safety and tolerability of the triple drug combination. We identified 15 potentially eligible studies, four of which met our inclusion criteria. Our findings indicate that co-formulated abacavir-lamivudine-zidovudine remains a viable option for initiating antiretroviral therapy, especially in HIV-infected patients with pre-existing hyperlipidaemia and those who do not tolerate ritonavir.

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    • "Both text words and medical subject heading (MeSH) terms, for example abacavir, antiretroviral, HIV, acquired immunodeficiency syndrome, child, paediatric, adolescent and randomised controlled trial will be used in the search strings. We will use these terms in different combinations with the adaptation of the literature search strategy to suit each database (see Additional file 1 for the proposed search strategy adapted from Shey et al. [19]). "
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