Article

Obsessive–Compulsive Symptoms and Related Sex Differences in Brain Structure: An MRI Study in Dutch Twins

Department of Biological Psychology, VU University, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Twin Research and Human Genetics (Impact Factor: 2.3). 04/2013; 16(2):516-24. DOI: 10.1017/thg.2013.10
Source: PubMed

ABSTRACT

Neuroimaging studies have indicated abnormalities in cortico-striato-thalamo-cortical circuits in obsessive-compulsive disorder patients, but results have not been consistent. Since there are significant sex differences in human brain anatomy and obsessive-compulsive symptomatology and its developmental trajectories tend to be distinct in males and females, we investigated whether sex is a potential source of heterogeneity in neuroimaging studies on obsessive-compulsive symptoms. We selected male and female twin pairs who were concordant for scoring either high or low for obsessive-compulsive symptoms and a group of discordant pairs where one twin scored high and the co-twin scored low. The design included 24 opposite-sex twin pairs. Magnetic resonance imaging scans of 31 males scoring high for obsessive-compulsive symptoms, 41 low-scoring males, 58 high-scoring females, and 73 low-scoring females were analyzed and the interaction of obsessive-compulsive symptoms by sex on gray matter volume was assessed using voxel-based morphometry. An obsessive-compulsive symptom by sex interaction was observed for the left middle temporal gyrus, the right middle temporal gyrus, and the right precuneus. These interactions acted to reduce or hide a main effect in our study and illustrate the importance of taking sex into account when investigating the neurobiology of obsessive-compulsive symptoms.

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    • "GOBS QTIM TAOS Adults NTR BrainSCALE NTR Relatedness Pedigree Twins and siblings Twins and siblings Twins Twins Race/ethnicity Mexican-American Caucasian Caucasian Caucasian Caucasian Number subjects contributed 859 625 319 246 199 Sex 351 M/508 F 231 M/394 F 158 M/161 F 93 M/153 F 100 M/99 F Age range (years) 19–85 21–29 12–15 18–45 9–10 Healthy Yes Yes Yes Yes Yes Scanner Siemens Bruker/Siemens Siemens Intera Achieva N-acquisitions 1 1 1 1 2 Field strength 3 T 4 T 3 T 3 T 1.5 T Voxel size (mm) 1.7 × 1.7 × 3.0 1.8 × 1.8 × 2 1.7 × 1.7 × 3.0 2.5 × 2.5 × 2.5 2.5 × 2.5 × 2.5 N-gradients 55 94 55 32 32 N-b 0 3 1 1 3 1 8 b-value (s/mm 2 ) 700 1159 700 1000 1000 Reference Kochunov et al., 2011 de Zubicaray et al., 2008 Kochunov et al., 2011 den Braber et al., 2013 Brouwer et al., 2010 "
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