Unilateral Humoral Rejection After Reoperative Single-Lung Transplant

Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
The Annals of thoracic surgery (Impact Factor: 3.85). 04/2013; 95(4):e79-81. DOI: 10.1016/j.athoracsur.2012.09.089
Source: PubMed


The role of antibody-mediated rejection in acute and chronic rejection after lung transplantation is poorly understood. We report the case of a prior single-lung transplant recipient undergoing an acute antibody-mediated rejection isolated to her new, contralateral single-lung transplant. A 44-year-old woman 6 years after undergoing a single-lung transplant for idiopathic pulmonary fibrosis underwent a second single-lung transplant for bronchiolitis obliterans syndrome. Despite a negative crossmatch, she subsequently exhibited severe antibody-mediated rejection to her new allograft within 6 days of transplantation. The process of allograft sensitization is dynamic, and further study is warranted to better understand this process.

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