Probiotics are essential for establishing and maintaining optimal immune health. The probiotic therapy is known
from alternative medicine for ages; however, the recent demonstration of the normal microflora to induce innate
immunity has introduced the science-based concept of therapeutic application of potentially beneficial probiotic
microorganisms for a treatment of functional disorders. Traditionally, probiotics are associated with dairy products,
however, novel formulations are needed, first of all, originated from naturally occurring symbiotic microbial
communities as the most robust assemblages. Especially, safe and robust probiotics are needed for longterm
expeditions, outposts, extraterrestrial permanently-manned bases, where humans are exposed to adverse
environmental factors. Kombucha beverage is Symbiotic Culture of Bacteria and Yeast (SCOBY) and associated
with health-promoting effects. Kombucha tea/mat is being in use in human livings within millennia as a probiotic
drink for healing and health prophylaxis effects, however, new research opportunities promise its «renaissance
», going to be used pharmacologically.