hERG channel function: Beyond long QT

Department of Neuroscience, High Throughput Biology Center and Johns Hopkins Ion Channel Center (JHICC), School of Medicine, Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, USA.
Acta Pharmacologica Sinica (Impact Factor: 2.91). 03/2013; 34(3):329-35. DOI: 10.1038/aps.2013.6
Source: PubMed


To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.

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Available from: PubMed Central, Jan 16, 2014 · License: CC BY-NC-ND
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    • "The human ether-à-go-go-related gene (hERG) product is a tetrameric potassium channel that plays an important role in cardiac action potential. Currently, a large number of clinical cases of drug-induced or acquired LQTs have been ascribed to the blockage of the hERG channel4,5. Therefore, it is necessary to measure the hERG inhibition activity of candidate compounds during drug discovery. "
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