Advances in the Multimodality Management of High-risk Prostate Cancer
Department of Radiation Medicine, Oregon Health and Science University, Southwest Sam Jackson Park Road, Portland, OR 97201, USA. Electronic address: .Surgical Oncology Clinics of North America (Impact Factor: 1.81). 04/2013; 22(2):375-94. DOI: 10.1016/j.soc.2012.12.012
Prostate cancer is a heterogeneous disease with marked variability in its natural progression and response to therapeutic interventions. It is the most commonly diagnosed visceral cancer of men living in western countries, yet it is life-threatening in only a minority of cases. Thus, appropriate patient selection for treatment based on tumor as well as patient characteristics is essential to achieve optimal outcomes. The combination of early cancer detection and technical improvements in local treatment has led to a reduction in disease burden and an increase in cancer survivorship. However, treatment failure remains common among high-risk cases.
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