Exhausting T cells in CLL

Article (PDF Available)inBlood 121(9):1485-6 · February 2013with7 Reads
DOI: 10.1182/blood-2013-01-475939 · Source: PubMed
In this issue of Blood, Riches and colleagues provide an in-depth characterization of T cells and particularly CD8+ T cells from patients with chronic lymphocytic leukemia (CLL). They demonstrate that CD8+ T cells exhibit defects in proliferation, cytotoxicity, and increased expression of inhibitory receptors and thus exhibit features of T-cell exhaustion.