Genetic Simulation Resources (GSR): A Website for the Registration and Discovery of Genetic Data Simulators

Department of Genetics, the University of Texas MD Anderson Cancer Center.
Bioinformatics (Impact Factor: 4.98). 02/2013; 29(8). DOI: 10.1093/bioinformatics/btt094
Source: PubMed


Many simulation methods and programs have been developed to simulate genetic data of the human genome. These data have been widely used, for example, to predict properties of populations retrospectively or prospectively according to mathematically intractable genetic models, and to assist the validation, statistical inference and power analysis of a variety of statistical models. However, owing to the differences in type of genetic data of interest, simulation methods, evolutionary features, input and output formats, terminologies and assumptions for different applications, choosing the right tool for a particular study can be a resource-intensive process that usually involves searching, downloading and testing many different simulation programs. Genetic Simulation Resources (GSR) is a website provided by the National Cancer Institute (NCI) that aims to help researchers compare and choose the appropriate simulation tools for their studies. This website allows authors of simulation software to register their applications and describe them with well-defined attributes, thus allowing site users to search and compare simulators according to specified features.

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Available from: Huann-Sheng Chen, Jan 28, 2014
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    • "Along with genomic data and phenotypic outcomes, simulation models may include environmental factors or exposures. To assist users and developers in comparing different simulators and selecting the one which is most appropriate for the scientific question being asked, the NCI created the Genetic Simulation Resources (GSR) website [Peng et al., 2013], a catalogue of genetic simulation programs where programs are described using a series of standardized attributes. One approach for advancing the science of simulation in a systematic manner is to establish forums for collaboration among simulation modelers [Mechanic et al., 2012]. "
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