Characteristics of B-cell lymphomas in HIV/HCV-coinfected patients during the combined antiretroviral therapy era: an ANRS CO16 LYMPHOVIR cohort study

ArticleinJAIDS Journal of Acquired Immune Deficiency Syndromes 63(2) · February 2013with30 Reads
Impact Factor: 4.56 · DOI: 10.1097/QAI.0b013e31828a77f0 · Source: PubMed

    Abstract

    Hepatitis C virus (HCV) infection is frequent among HIV infected patients. We describe the characteristics of 6 HIV-HCV coinfected patients with B-cell non-Hodgkin lymphoma (NHL) included in a prospective cohort study of HIV related lymphomas. Five of the six cases had features of marginal zone/lymphoplasmacytic NHL versus one out of 33 HIV only infected patients. Remarkably, anti-HCV treatment led to a hematological response in a patient with splenic marginal zone lymphoma. This supports the role of chronic antigenic stimulation by HCV on lymphomagenesis and further evaluation of HCV antiviral therapy in coinfected patients with NHL.