Vascular risk and FDDNP-PET influence cognitive performance

Division of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA, USA.
Journal of Alzheimer's disease: JAD (Impact Factor: 4.15). 02/2013; 35(1). DOI: 10.3233/JAD-121903
Source: PubMed


The relationship of cerebrovascular risk and Alzheimer's disease (AD) pathology to cognition in pre-dementia has been extensively investigated and is well-established. Cerebrovascular risk can be measured using a Framingham Stroke Risk Profile (FSRP) score, while positron emission tomography (PET) scans with 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) measure AD neuropathology (i.e., amyloid-β plaques and tau tangles). Here we report results of 75 healthy non-demented subjects (mean age, 63 years) who underwent neuropsychological testing, physical assessments, and FDDNP-PET scans. Controlling for AD family history, education, and APOE4 status in a general linear model, higher FSRP risk and global FDDNP-PET binding were each associated with poorer cognitive functioning. The interaction of FSRP and global FDDNP-PET binding was not significant in the model, indicating that stroke risk and plaque and tangle burden each contributed to worse cognitive performance. Within our healthy volunteers, age, blood pressure, and antihypertensive medication use were vascular risks that contributed significantly to the above findings. These findings suggest that even mild cerebrovascular risk may influence the extent of cognitive dysfunction in pre-dementia, along with amyloid-β and tau burden.

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Available from: David A Merrill, Feb 27, 2015
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    ABSTRACT: The ability for patients to understand their risk for disease is important to early intervention and effective treatment. The link between individual cardiovascular risk factors and cognition has been well-established. This study investigated the relationship between cognition and a combination of these factors through a single composite risk score. This study quantitatively summarized the strength of the association between composite cardiovascular risk scores and cognitive test performance using meta-analytic methods. One hundred and nine effect sizes were obtained from 19 studies employing 54,564 participants. Composite risk scores showed a significant association (r = -0.16) with cognitive test performance. Cognitive domain and age did not significantly modify this relationship. Composite cardiovascular risk scores can be useful indicators of future cognition. The development of a dementia risk score using similar risk factors could aid in the assessment and lifestyle interventions of persons at risk for dementia.
    No preview · Article · Jan 2015 · Annals of Behavioral Medicine