Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi

ArticleinOrganic Letters 15(4) · January 2013with15 Reads
Impact Factor: 6.36 · DOI: 10.1021/ol303435y · Source: PubMed


    Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC(50) of 3 μM, suggestive of a physiological role as an immunosuppressive agent.