Human cortical sensorimotor network underlying feedback control of vocal pitch

Departments of Neurological Surgery, Otolaryngology, and Radiology, University of California, San Francisco, CA 94143.
Proceedings of the National Academy of Sciences (Impact Factor: 9.67). 01/2013; 110(7). DOI: 10.1073/pnas.1216827110
Source: PubMed


The control of vocalization is critically dependent on auditory feedback. Here, we determined the human peri-Sylvian speech network that mediates feedback control of pitch using direct cortical recordings. Subjects phonated while a real-time signal processor briefly perturbed their output pitch (speak condition). Subjects later heard the same recordings of their auditory feedback (listen condition). In posterior superior temporal gyrus, a proportion of sites had suppressed responses to normal feedback, whereas other spatially independent sites had enhanced responses to altered feedback. Behaviorally, speakers compensated for perturbations by changing their pitch. Single-trial analyses revealed that compensatory vocal changes were predicted by the magnitude of both auditory and subsequent ventral premotor responses to perturbations. Furthermore, sites whose responses to perturbation were enhanced in the speaking condition exhibited stronger correlations with behavior. This sensorimotor cortical network appears to underlie auditory feedback-based control of vocal pitch in humans.

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Available from: Caroline A Niziolek, Nov 25, 2015
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    • "or - correction mechanism changes the motor commands based on the mismatch . For example , when the auditory feedback of our own voice is artificially pitch - shifted , the auditory - motor system compensates for these perturbations by modulating the motor commands , which results in the pitch - shifting of our own voice ( Burnett et al . , 1998 ; Chang et al . , 2013 ) , and the compensation of the auditory - motor system for delayed auditory feedback ( DAF ) results in increased phonation time and phonation errors ( Yates , 1963 ) . On the other hand , feedforward control relies on the previously learned correlation between motor commands and their outcomes ( i . e . , sensory - motor neural mappin"
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    ABSTRACT: Individuals with autism spectrum disorder (ASD) show impaired social interaction and communication, which may be related to their difficulties in speech production. To investigate the mechanisms of atypical speech production in this population, we examined feedback control by delaying the auditory feedback of their own speech, which degraded speech fluency. We also examined feedforward control by adding loud pink noise to the auditory feedback, which led to increased vocal effort in producing speech. The results of Japanese speakers show that, compared with neurotypical (NT) individuals, high-functioning adults with ASD (including Asperger’s disorder, autistic disorder, and pervasive developmental disorder not otherwise specified) were more affected by delayed auditory feedback but less affected by external noise. These findings indicate that, in contrast to NT individuals, those with ASD relied more on feedback control than on feedforward control in speech production, which is consistent with the hypothesis that this population exhibits attenuated Bayesian priors.
    Full-text · Article · Sep 2015 · Frontiers in Human Neuroscience
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    • "By contrast , when there is a mismatch between auditory feedback and vocal output, vocalisation elicits larger neural responses than during passive listening (Eliades & Wang, 2008; Behroozmand et al., 2009; Chang et al., 2013; Chen et al., 2013). This enhanced cortical activity is thought to reflect a mechanism that serves to compensate for errors perceived during vocalisation (Chang et al., 2013). Although recent research has greatly advanced our understanding of the integration of sensory and motor information during speech, we know little about the role, if any, that attention plays. "
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    Full-text · Article · May 2015 · European Journal of Neuroscience
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    • "As mentioned earlier , this notion is corroborated by our findings showing that the power of the induced delta com - ponent was significantly correlated with the degree of PRE in the NM compared with AP and RP groups . It is worthwhile to mention that , compared with similar previ - ous studies ( Houde et al . , 2002 ; Behroozmand et al . , 2009 ; Chang et al . , 2013 ; Greenlee et al . , 2013 ) , a shortcoming of the present study was the absence of the playback condition . The inclusion of the playback condition and comparing its results with speaking could potentially have additional benefits because it would have allowed us to study sensory and motor mechanisms of voice pitch motor control indepen"
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