Increasing HIV testing among male partners. The Prenahtest ANRS 12127 multi-country randomised trial

aUniversity Bordeaux, ISPED, Centre Inserm U897- Epidemiologie-Biostatistique, F-33000 Bordeaux, France bINSERM, ISPED, Centre Inserm U897- Epidemiologie-Biostatistique, F-33000 Bordeaux, France cLaboratoire d'Epidémiologie et de Santé Publique, Centre Pasteur du Cameroun, Yaoundé, Cameroun dCentro Nacional de Investigaciones en Salud Materno Infantil, Santo Domingo, Dominican Republic ePrayas Health Group, Prayas, Pune, India fMaternal and Child Care Union, Neoclinic, Tbilisi, Georgia gInstitut de Recherche pour le Développement, UMR 912 IRD-INSERM-U2, Marseille, France hInstitut de Recherche pour le Développement, CEPED UMR Sorbonne Paris Descartes -INED-IRD, Paris, France iRéseau International des Instituts Pasteurs, Paris, France.
AIDS (London, England) (Impact Factor: 5.55). 01/2013; 27(7). DOI: 10.1097/QAD.0b013e32835f1d8c
Source: PubMed


OBJECTIVE:: Couple-oriented post-test HIV counselling (COC) provides pregnant women with tools and strategies to invite her partner to HIV counselling and testing. We conducted a randomised trial of the efficacy of COC on partner HIV testing in low/medium HIV prevalence settings (Cameroon, Dominican Republic, Georgia, India). METHODS:: Pregnant women were randomised to receive standard post-test HIV counselling (SC) or COC and followed until six months postpartum. Partner HIV testing events were notified by site laboratories, self-reported by women or both combined. Impact of COC on partner HIV testing was measured in intention-to-treat analysis. Socio-behavioural factors associated with partner HIV testing were evaluated using multivariable logistic regression. RESULTS:: Among 1943 pregnant women enrolled, partner HIV testing rates (combined indicator) were 24.7% among women from COC group vs 14.3% in SC group in Cameroon (Odds Ratio [OR] = 2.0 95%CI [1.2-3.1]), 23.1% vs 20.3% in Dominican Republic (OR = 1.2 [0.8-1.8]), 26.8% vs 1.2% in Georgia (OR = 29.6 [9.1-95.6]) and 35.4% vs 26.6% in India (OR = 1.5 [1.0-2.2]). Women having received COC did not report more conjugal violence or union break-ups than in the SC group. The main factors associated with partner HIV testing were a history of HIV testing among men in Cameroon, Dominican Republic and Georgia and the existence of couple communication around HIV testing in Georgia and India. CONCLUSION:: A simple prenatal intervention taking into account the couple relationship increases the uptake of HIV testing among men in different socio-cultural settings. COC could contribute to the efforts towards eliminating mother-to-child transmission of HIV.

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    • "This concern arises from evidence indicating that the majority of sexual and physical violence against women is perpetrated by intimate male partners (Campbell, 1989), with a clear link between partner violence and risk of HIV and other sexually transmitted diseases (STDs; Maman, Campbell, Sweat, & Gielen, 2000). Couple-based HIV counseling might potentially trigger an adverse reaction by one or both partners to disclosure of sensitive information (e.g., previously undisclosed HIV infection, admission of infidelity) or to unresolved relationship issues (e.g., prior abuse, lack of trust, power dynamics; Grinstead, Gregorich, Choi, & Coates, 2001; Kamenga et al., 1991; Kiarie et al., 2006; Mlay, Lugina, & Becker, 2008; Njau, Watt, Ostermann, Manongi, & Sikkema, 2012; Orne-Gliemann et al., 2013; Tabana et al., 2013). The potential for an adverse or violent reaction by one partner to disclosure of a previously unknown HIV diagnosis in the other has been documented in several studies (Coates et al., 2000; Gielen et al., 2000; Gielen, O'Campo, Faden, & Eke, 1997; Grinstead et al., 2001; Musheke, Bond, & Merten, 2013; Simoni et al., 1995; Tabana et al., 2013). "
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    ABSTRACT: Heterosexual transmission of HIV often occurs in the context of intimate sexual partnerships. There is mounting evidence that couple-based HIV prevention interventions may be more effective than individual-based interventions for promoting risk reduction within such relationships. Yet, concerns have been raised about the safety of couple-based prevention approaches, especially with regard to the risk of intimate partner violence against women. Although several international studies have examined the potential for adverse consequences associated with couple-based interventions, with inconsistent results, there is little data from U.S. studies to shed light on this issue. The current study analyzed data from a randomized trial conducted in New York City with 330 heterosexual couples to examine whether participation in couple-based or relationship-focused HIV counseling and testing (HIV-CT) interventions resulted in an increased likelihood of post-intervention breakups, relationship conflicts, or emotional, physical, or sexual abuse, compared with standard individual HIV-CT. Multinomial logistic regression was used to model the odds of experiencing change in partner violence from baseline to follow-up by treatment condition. A high prevalence of partner-perpetrated violence was reported by both male and female partners across treatment conditions, but there was no conclusive evidence of an increase in relationship dissolution or partner violence subsequent to participation in either the couple-based HIV-CT intervention or relationship-focused HIV-CT intervention compared with controls. Qualitative data collected from the same participants support this interpretation. HIV prevention interventions involving persons in primary sexual partnerships should be sensitive to relationship dynamics and the potential for conflict, and take precautions to protect the safety of both male and female participants. © The Author(s) 2015.
    Full-text · Article · Aug 2015 · Journal of Interpersonal Violence
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    • "CHCT necessitates the testing and mutual disclosure of both partners, conditions that are essential for improving subsequent outcomes such as sexual risk reduction and improving treatment outcomes. Although interventions aimed towards improving rates of testing for male partners of antenatal clinic attendees have had similar goals, they have reported mixed results [64,65]. "
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    ABSTRACT: Couples-based HIV counseling and testing (CHCT) is a proven strategy to reduce the risk of HIV transmission between partners, but uptake of CHCT is low. We describe the study design of a randomized controlled trial (RCT) aimed to increase participation in CHCT and reduce sexual risk behavior for HIV among heterosexual couples in rural KwaZulu-Natal, South Africa. We hypothesize that the rate of participation in CHCT will be higher and sexual risk behavior will be lower in the intervention group as compared to the control.Methods/design: Heterosexual couples (N = 350 couples, 700 individuals) are being recruited to participate in a randomized trial of a couples-based intervention comprising two group sessions (one mixed gender, one single gender) and four couples' counseling sessions. Couples must have been in a relationship together for at least 6 months. Quantitative assessments are conducted via mobile phones by gender-matched interviewers at baseline, 3, 6, and 9 months post-randomization. Intervention content is aimed to improve relationship dynamics, and includes communication skills and setting goals regarding CHCT. The Uthando Lwethu ('our love') intervention is the first couples-based intervention to have CHCT as its outcome. We are also targeting reductions in unprotected sex. CHCT necessitates the testing and mutual disclosure of both partners, conditions that are essential for improving subsequent outcomes such as disclosure of HIV status, sexual risk reduction, and improving treatment outcomes. Thus, improving rates of CHCT has the potential to improve health outcomes for heterosexual couples in a rural area of South Africa that is highly impacted by HIV. The results of our ongoing clinical trial will provide much needed information regarding whether a relationship-focused approach is effective in increasing rates of participation in CHCT. Our intervention represents an attempt to move away from individual-level conceptualizations, to a more integrated approach for HIV prevention.Trial registration: Study Name: Couples in Context: An RCT of a Couples-based HIV Prevention identifier: NCT01953133.South African clinical trial registration number: DOH-27-0212-3937.
    Full-text · Article · Feb 2014 · Trials
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    ABSTRACT: HIV testing male partners of pregnant women may decrease HIV transmission to women and promote uptake of prevention of mother-to-child HIV transmission (PMTCT) interventions. However, it has been difficult to access male partners in antenatal care (ANC) clinics. We hypothesized that home visits to offer HIV testing to partners of women attending ANC would increase partner HIV testing. Women attending their first ANC were enrolled, interviewed using smartphone audio-computer assisted self-interviews and randomized to home visits or written invitations for male partners to come to clinic, if they were married or cohabiting, unaccompanied by partners and had no prior couple HIV counselling and testing (CHCT). Enrolled men were offered CHCT (HIV testing and mutual disclosure). Prevalence of CHCT, male HIV seropositivity, couple serodiscordance and intimate partner violence, reported as physical threat from partner, were compared at 6 weeks. Among 495 women screened, 312 were eligible, and 300 randomized to clinic-based or home-based CHCT. Median age was 22 years (interquartile range 20-26 years), and 87% were monogamous. CHCT was significantly higher in home-visit than in clinic-invitation arm (n = 128, 85% vs. n = 54, 36%; P < 0.001). Home-arm identified more HIV-seropositive men (12.0 vs. 8.0%; P = 0.248) and more HIV-discordant couples (14.7 vs. 4.7%; P = 0.003). There was no difference in intimate partner violence. Home visits of pregnant women were safe and resulted in more male partner testing and mutual disclosure of HIV status. This strategy could facilitate prevention of maternal HIV acquisition, improve PMTCT uptake and increase male HIV diagnosis.
    No preview · Article · Aug 2013 · AIDS (London, England)
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